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Amongst the advanced cardiac imaging modalities, multi-slice computed tomography MSCT has emerged as a reliable non-invasive method for the assessment of coronary anatomy, coronary artery disease, and cardiac function [1–16]. Multiple studies involving over several thousands of patients have established that MSCT is highly accurate for delineation of the presence and severity of coronary atherosclerosis [17–30]. MSCT may also reveal the total plaque burden, i.e., both calcified and non-calcified components, for individual patients with coronary atherosclerosis [31–38]. The advent of prospectively gated acquisition techniques for 64-slice MSCT has deepened our insight in soft versus hard plaques together with a significant reduction in dose exposure [39–43]. Apart from MSCT, plaque calcifications can also be recognized by MRI and, in particular, by intravascular ultrasound (IVUS) [44–49]. However, smaller calcifications might be missed on MSCT due to its lower resolution and it is unknown to which extent calcifications can be detected with MSCT.
In the current issue of the International Journal of Cardiovascular Imaging, van der Giessen et al. [50] compared the detection of calcifications on contrast enhanced MSCT with IVUS. They randomly selected 23 patients (18 male, mean age 54 ± 11 years) from the subpopulation that was imaged for the PROSPECT trial. The authors aimed for 100 calcifications on IVUS, which was reached by inclusion of 23 patients. Of these patients only non-stented coronary arteries were included. The coronary arteries of patients with myocardial infarction or unstable angina were imaged by 64-slice MSCT angiography and IVUS. The IVUS and MSCT images were registered and the arteries were evaluated on the presence of calcifications on both modalities independently. The length and the maximum circumferential angle of each calcification on IVUS were measured. In 31 arteries, 99 calcifications on IVUS were found, of which only 47 calcifications were also detected on MSCT. A total of 107 calcifications were identified on either IVUS or MSCT. We identified calcifications on both IVUS and MSCT, 52 calcifications were identified on IVUS only and 8 were identified on MSCT only. The calcifications missed on MSCT (n = 52) were significantly smaller in angle (27° ± 16° vs. 59° ± 31°) and length (1.4 ± 0.8 vs. 3.7 ± 2.2 mm) than those detected by IVUS. Calcifications could only be detected reliably on MSCT if they were larger than 2.1 mm in length or 36° in angle. The authors concluded that more than half (53%) of the calcifications seen on the IVUS images could not be detected on contrast enhanced 64-slice MSCT angiography images because of their size.
This is the first study [50] that compares the ability to detect coronary calcifications in contrast enhanced 64-slice MSCT and IVUS on a cross-sectional basis. The authors claim the limited resolution of MSCT in combination with the obscuring effects of the contrast in the lumen as the main reason for missing small calcifications. The findings are at variance with previous comparisons between MSCT and IVUS which showed generally good to excellent correlations [51, 52]. The authors legitimate their findings by stating that the presence of calcifications by previous studies was examined on a vessel or segmental basis rather than on a cross-sectional basis. This difference might explain the discrepancy between previous and present findings. A cross-sectional approach might potentially detect more calcified lesions. However, the authors make a bigger case for the ‘poor’ resolution of MSCT versus IVUS as the main explanation for their findings.
In general, IVUS image quality can be described by two important resolution issues: (1) spatial resolution (axial and lateral resolution), and (2) contrast resolution (grayscale/dynamic range). The spatial resolution (axial and lateral resolution) is the ability to discriminate small adjacent objects within the image. It depends on the MHz level: the lower the MHz, the deeper the image penetration, the higher the MHz, the higher the image quality. For a 40 MHz IVUS transducer the typical resolution is 80–100 microns axially and 200–250 microns laterally. The contrast resolution (dynamic range) offers the capacity to differentiate different tissues. Distribution of the gray-scale of the reflected signal; a low dynamic range “black and white” with only a few “in between” gray-scale levels versus a high dynamic range image which has more shades of gray, is often “softer” and has more preserved subtleties in the image presentation. Based on these parameters, IVUS technology is capable of 500–600 images per centimeter of artery. It also shows a 360° cross-sectional view allowing the visualization of lumen size and shape together with plaque topography and composition. In the present study [50], a 40MHz IVUS was used providing a stack of gated IVUS images with an axial spacing of approximately 0.5 mm.
Although the spatial resolution is excellent for IVUS compared to MSCT, the spatial resolution for MSCT is theoretically better than ‘poor’. In a review article by the same group, both the spatial resolution and the temporal resolution for MSCT were called high. Mollet et al. [53] reported that the spatial resolution in the x/y axis of current MSCT scanners is 0.4 × 0.4 mm. The spatial resolution in the z axis is determined by the minimum slice thickness, which varies from 0.5 to 0.75 mm depending on the manufacturer. These features permit reconstruction of high quality images with a sub-millimeter, nearly isotropic (same size in every dimension) voxel size. This high spatial resolution reduces partial volume effects and also allows visualization of coronary segments down to diameters of 1.5–2 mm. In the present study [50], using a 64-slice MSCT scanner, the in-plane voxel size was 0.3 mm and the slice thickness 0.4 mm. This might be slightly improved by using 320-row MSTC scanners but the main advantage of 320-row MSCT is its improved temporal resolution [54–56]. Consequently, the spatial resolution of MSCT is inferior to that of IVUS but cannot be labeled as strictly ‘poor’.
To conclude, the interesting study by van der Giessen et al. [50] clearly shows that 53% of the calcifications seen on the IVUS images cannot be detected on contrast-enhanced 64-slice MSCT angiography images because of their size. Both differences in spatial resolution and the evaluation by IVUS on a cross-sectional basis rather than on a vessel or segmental basis play a dominant role in explaining the observed phenomenon.
References
Schuijf JD, Jukema JW, van der Wall EE, Bax JJ (2007) Multi-slice computed tomography in the evaluation of patients with acute chest pain. Acute Card Care 9:214–221
Schuijf JD, Pundziute G, Jukema JW et al (2006) Diagnostic accuracy of 64-slice multislice computed tomography in the noninvasive evaluation of significant coronary artery disease. Am J Cardiol 98:145–148
van Werkhoven JM, Schuijf JD, Jukema JW et al (2008) Anatomic correlates of a normal perfusion scan using 64-slice computed tomographic coronary angiography. Am J Cardiol 101:40–45
Scholte AJ, Bax JJ, Wackers FJ (2006) Screening of asymptomatic patients with type 2 diabetes mellitus for silent coronary artery disease: combined use of stress myocardial perfusion imaging and coronary calcium scoring. J Nucl Cardiol 13:11–18
Wijpkema JS, Dorgelo J, Willems TP et al (2007) Discordance between anatomical and functional coronary stenosis severity. Neth Heart J 15:5–11
Molhoek SG, Bax JJ, Bleeker GB et al (2004) Comparison of response to cardiac resynchronization therapy in patients with sinus rhythm versus chronic atrial fibrillation. Am J Cardiol 94:1506–1509
Roeters van Lennep JE, Westerveld HT, Erkelens DW, van der Wall EE (2002) Risk factors for coronary heart disease: implications of gender. Cardiovasc Res 53:538–549
Groen JM, Greuter MJ, Vliegenthart R et al (2008) Calcium scoring using 64-slice MDCT, dual source CT and EBT: a comparative phantom study. Int J Cardiovasc Imaging 24:547–556
de Leeuw JG, Wardeh A, Sramek A, van der Wall EE (2007) Pseudo-aortic dissection after primary PCI. Neth Heart J 15:265–266
ten Kate GJ, Wuestink AC, de Feyter PJ (2008) Coronary artery anomalies detected by MSCT-angiography in the adult. Neth Heart J 16:369–375
Hoogendoorn LI, Pattynama PM, Buis B, van der Geest RJ, van der Wall EE, de Roos A (1995) Noninvasive evaluation of aortocoronary bypass grafts with magnetic resonance flow mapping. Am J Cardiol 75:845–848
de Nooijer R, Verkleij CJ, Von der Thüsen JH et al (2006) Lesional overexpression of matrix metalloproteinase-9 promotes intraplaque hemorrhage in advanced lesions but not at earlier stages of atherogenesis. Arterioscler Thromb Vasc Biol 26:340–346
Van de Veire NR, Schuijf JD, De Sutter J et al (2006) Non-invasive visualization of the cardiac venous system in coronary artery disease patients using 64-slice computed tomography. J Am Coll Cardiol 48:1832–1838
van der Wall EE, den Hollander W, Heidendal GA, Westera G, Majid PA, Roos JP (1981) Dynamic myocardial scintigraphy with 123I-labeled free fatty acids in patients with myocardial infarction. Eur J Nucl Med 6:383–389
Braun S, van der Wall EE, Emanuelsson S, Kobrin I (1996) Effects of a new calcium antagonist, mibefradil (Ro 40-5967), on silent ischemia in patients with stable chronic angina pectoris: a multicenter placebo-controlled study. The mibefradil international study group. J Am Coll Cardiol 27:317–322
Schuijf JD, Bax JJ, Shaw LJ et al (2006) Meta-analysis of comparative diagnostic performance of magnetic resonance imaging and multislice computed tomography for noninvasive coronary angiography. Am Heart J 151:404–411
Ypenburg C, van der Wall EE, Schalij MJ, Bax JJ (2008) Imaging in cardiac resynchronisation therapy. Neth Heart J 16:S36–S40
Ypenburg C, Van De Veire N, Westenberg JJ et al (2008) Noninvasive imaging in cardiac resynchronization therapy-Part 2: follow-up and optimization of settings. Pacing Clin Electrophysiol 31:1628–1639
Ypenburg C, Sieders A, Bleeker GB et al (2007) Myocardial contractile reserve predicts improvement in left ventricular function after cardiac resynchronization therapy. Am Heart J 154:1160–1165
Ypenburg C, Schalij MJ, Bleeker GB et al (2007) Impact of viability and scar tissue on response to cardiac resynchronization therapy in ischaemic heart failure patients. Eur Heart J 28:33–41
Ypenburg C, Roes SD, Bleeker GB et al (2007) Effect of total scar burden on contrast-enhanced magnetic resonance imaging on response to cardiac resynchronization therapy. Am J Cardiol 99:657–660
Bleeker GB, Kaandorp TA, Lamb HJ et al (2006) Effect of posterolateral scar tissue on clinical and echocardiographic improvement after cardiac resynchronization therapy. Circulation 113:969–976
Bleeker GB, Bax JJ, Fung JW et al (2006) Clinical versus echocardiographic parameters to assess response to cardiac resynchronization therapy. Am J Cardiol 97:260–263
Bleeker GB, Holman ER, Steendijk P et al (2006) Cardiac resynchronization therapy in patients with a narrow QRS complex. J Am Coll Cardiol 48:2243–2250
Bleeker GB, Schalij MJ, Boersma E et al (2007) Relative merits of M-mode echocardiography and tissue Doppler imaging for prediction of response to cardiac resynchronization therapy in patients with heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol 99:68–74
van Rugge FP, van der Wall EE, Bruschke AV (1992) New developments in pharmacologic stress imaging. Am Heart J 124:468–485
Schuijf JD, Bax JJ, van der Wall EE (2007) Anatomical and functional imaging techniques: basically similar or fundamentally different? Neth Heart J 15:43–44
Nemes A, Geleijnse ML, van Geuns RJ et al (2008) Dobutamine stress MRI versus threedimensional contrast echocardiography: it’s all Black and White. Neth Heart J 16:217–218
Vliegen HW, Doornbos J, de Roos A, Jukema JW, Bekedam MA, van der Wall EE (1997) Value of fast gradient echo magnetic resonance angiography as an adjunct to coronary arteriography in detecting and confirming the course of clinically significant coronary artery anomalies. Am J Cardiol 79:773–776
van der Wall EE, van Dijkman PR, de Roos A et al (1990) Diagnostic significance of gadolinium-DTPA (diethylenetriamine penta-acetic acid) enhanced magnetic resonance imaging in thrombolytic treatment for acute myocardial infarction: its potential in assessing reperfusion. Br Heart J 63:12–17
Henneman MM, Schuijf JD, Pundziute G et al (2008) Noninvasive evaluation with multislice computed tomography in suspected acute coronary syndrome: plaque morphology on multislice computed tomography versus coronary calcium score. J Am Coll Cardiol 52:216–222
Groenink M, Lohuis TA, Tijssen JG et al (1999) Survival and complication free survival in Marfan’s syndrome: implications of current guidelines. Heart 82:499–504
van der Laarse A, Kerkhof PL, Vermeer F et al (1988) Relation between infarct size and left ventricular performance assessed in patients with first acute myocardial infarction randomized to intracoronary thrombolytic therapy or to conventional treatment. Am J Cardiol 61:1–7
van der Laan A, Hirsch A, Nijveldt R et al (2008) Bone marrow cell therapy after acute myocardial infarction: the HEBE trial in perspective, first results. Neth Heart J 16:436–439
Bakx AL, van der Wall EE, Braun S, Emanuelsson H, Bruschke AV, Kobrin I (1995) Effects of the new calcium antagonist mibefradil (Ro 40–5967) on exercise duration in patients with chronic stable angina pectoris: a multicenter, placebo-controlled study. Ro 40-5967 International Study Group. Am Heart J 130:748–757
Torn M, Bollen WL, van der Meer FJ, van der Wall EE, Rosendaal FR (2005) Risks of oral anticoagulant therapy with increasing age. Arch Intern Med 165:1527–1532
van der Wall EE, Heidendal GA, den Hollander W, Westera G, Roos JP (1980) I-123 labeled hexadecenoic acid in comparison with thallium-201 for myocardial imaging in coronary heart disease. A preliminary study. Eur J Nucl Med 5:401–405
van Rugge FP, Boreel JJ, van der Wall EE et al (1991) Cardiac first-pass and myocardial perfusion in normal subjects assessed by sub-second Gd-DTPA enhanced MR imaging. J Comput Assist Tomogr 15:959–965
Nijveldt R, Beek AM, Hirsch A et al (2008) ‘No-reflow’ after acute myocardial infarction: direct visualisation of microvascular obstruction by gadolinium-enhanced CMR. Neth Heart J 16:179–181
van der Geest RJ, Niezen RA, van der Wall EE, de Roos A, Reiber JH (1998) Automated measurement of volume flow in the ascending aorta using MR velocity maps: evaluation of inter- and intraobserver variability in healthy volunteers. J Comput Assist Tomogr 22:904–911
Portegies MC, Schmitt R, Kraaij CJ et al (1991) Lack of negative inotropic effects of the new calcium antagonist Ro 40-5967 in patients with stable angina pectoris. J Cardiovasc Pharmacol 18:746–751
Tops LF, Schalij MJ, Holman ER, van Erven L, van der Wall EE, Bax JJ (2006) Right ventricular pacing can induce ventricular dyssynchrony in patients with atrial fibrillation after atrioventricular node ablation. J Am Coll Cardiol 48:1642–1648
Tops LF, Bax JJ, Zeppenfeld K et al (2005) Fusion of multislice computed tomography imaging with three-dimensional electroanatomic mapping to guide radiofrequency catheter ablation procedures. Heart Rhythm 2:1076–1081
Oemrawsingh PV, Mintz GS, Schalij MJ, Zwinderman AH, Jukema JW, van der Wall EE (2003) Intravascular ultrasound guidance improves angiographic and clinical outcome of stent implantation for long coronary artery stenoses: final results of a randomized comparison with angiographic guidance (TULIP Study). Circulation 107:62–67
van der Hoeven BL, Liem SS, Oemrawsingh PV et al (2006) Role of calcified spots detected by intravascular ultrasound in patients with ST-segment elevation acute myocardial infarction. Am J Cardiol 98:309–313
Goertz DE, Frijlink ME, Krams R, de Jong N, van der Steen AF (2007) Vasa vasorum and molecular imaging of atherosclerotic plaques using nonlinear contrast intravascular ultrasound. Neth Heart J 15:77–80
van Soest G, Goderie TP, Gonzalo N et al (2009) Imaging atherosclerotic plaque composition with intracoronary optical coherence tomography. Neth Heart J 17:448–450
Groen HC, Gijsen FJ, van der Lugt A et al (2008) High shear stress influences plaque vulnerability. Part of the data presented in this paper were published in Stroke 2007;38:2379–2381. Neth Heart J 16:280–283
van der Giessen AG, Schaap M, Gijsen FJ et al (2009) 3D fusion of intravascular ultrasound and coronary computed tomography for in vivo wall shear stress analysis: a feasibility study. Int J Cardiovasc Imaging. doi:10.1007/s10554-010-9546-y
van der Giesen AG, Gijsen FJ, Wentzel JJ et al (2010) Small coronary calcifications are not detectable by 64-slice contrast enhanced computed tomography. Int J Cardiovasc Imaging. doi:10.1007/s10554-010-9662-8
van Velzen JE, Schuijf JD, de Graaf FR et al (2009) Plaque type and composition as evaluated non-invasively by MSCT angiography and invasively by VH IVUS in relation to the degree of stenosis. Heart 95:1990–1996
Pundziute G, Schuijf JD, van Velzen JE et al (2010) Assessment with multi-slice computed tomography and gray-scale and virtual histology intravascular ultrasound of gender-specific differences in extent and composition of coronary atherosclerotic plaques in relation to age. Am J Cardiol 105:480–486
Mollet NR, Cademartiri F, de Feyter PJ (2005) Noninvasive multislice CT coronary imaging. Heart 91:401–407
de Graaf FR, Schuijf JD, van Velzen JE et al (2010) Diagnostic accuracy of 320-row multidetector computed tomography coronary angiography to noninvasively assess in-stent restenosis. Invest Radiol 45:331–340
de Graaf FR, Schuijf JD, van Velzen JE et al (2010) Assessment of global left ventricular function and volumes with 320-row multidetector computed tomography: a comparison with 2D-echocardiography. J Nucl Cardiol 17:225–331
de Graaf FR, Schuijf JD, van Velzen JE et al (2010) Diagnostic accuracy of 320-row multidetector computed tomography coronary angiography in the non-invasive evaluation of significant coronary artery disease. Eur Heart J. Jan 4 [Epub ahead of print]
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van der Wall, E.E., de Graaf, F.R., van Velzen, J.E. et al. IVUS detects more coronary calcifications than MSCT; matter of both resolution and cross-sectional assessment?. Int J Cardiovasc Imaging 27, 1011–1014 (2011). https://doi.org/10.1007/s10554-010-9668-2
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DOI: https://doi.org/10.1007/s10554-010-9668-2