A model of osteochondral intra-articular defect in rats is presented. During spontaneous healing, the stage of formation of granulation tissue is followed by its replacement with bone and fibrous tissue. Chondroinductive properties of collagen 1 sponge used for defect filling manifested in the formation of fibrous cartilage with fields of hyaline cartilage. Filling of the defect with collagen 1 sponge containing bone powder stimulated regeneration of the bone tissue and hyaline cartilage.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 146, No. 11, pp. 597–600, November, 2008
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Khubutiya, M.S., Kliukvin, I.Y., Istranov, L.P. et al. Stimulation of Regeneration of Hyaline Cartilage in Experimental Osteochondral Injury. Bull Exp Biol Med 146, 658–661 (2008). https://doi.org/10.1007/s10517-009-0356-y
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DOI: https://doi.org/10.1007/s10517-009-0356-y