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Efficacy of N95 amplitude of pattern electroretinogram measured from baseline to N95 trough in the traumatic optic neuropathy

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To investigate the utility of selected pattern electroretinogram (PERG) parameters—including N95 amplitude and N95/P50 ratio, and a BL-N95 amplitude—in the analysis of visual function(s) and for predicting changes in retinal ganglion cell structures in traumatic optic neuropathy.

Study design

A retrospective, observational case series performed at a single center.

Methods

Forty-four eyes from 36 patients diagnosed with optic neuropathy were included. A BL-N95 amplitude was defined as the amplitude measured from baseline to the trough of N95. PERG and pattern visual evoked potential (pVEP) measures were acquired within 1 week after onset of optic neuropathies. To compare functional and anatomical changes, mean temporal peripapillary retinal nerve fiber layer (pRNFL) and average and minimum ganglion cell-inner plexiform layer (GC-IPL) thicknesses were measured using optical coherence tomography.

Results

Thirty-six patients (20 men, 16 women; mean age 37.5 ± 17.6 years) were evaluated. The BL-N95 amplitude was significantly smaller than the N95 amplitude (1.01 ± 0.56 μV and 2.45 ± 1.02 μV, respectively; p  < 0.0001). Both the N95 (r  = − 0.38, p  = 0.010) and BL-N95 r  = − 0.32, p  = 0.029) amplitudes were significantly correlated with visual acuity. Although P100 latency was not correlated with all PERG parameters, the N95 (r  = 0.32, p  = 0.032) and BL-N95 (r  = 0.41, p  = 0.005) amplitudes demonstrated a positive correlation with P100 amplitude in pVEP. PERG parameters, including the N95 and BL-N95 amplitudes, and N95/P50 ratio, were not correlated with pRNFL thickness in optical coherence tomography. Only the BL-N95 amplitude demonstrated a significant correlation with GC-IPL.

Conclusion

The BL-N95 amplitude―measured from baseline to the trough of N95―was valuable in the analysis of visual function(s) and for predicting changes in retinal ganglion cell structures in traumatic optic neuropathy.

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Funding

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Authors and Affiliations

  1. Department of Ophthalmology, Kim’s Eye Hospital, Youngshin-ro 136, Youngdeungpo-gu, Seoul, 07301, Korea

    Kun Hae Kim & Ungsoo Samuel Kim

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  1. Kun Hae Kim
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  2. Ungsoo Samuel Kim
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Correspondence to Ungsoo Samuel Kim.

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K. H. Kim, None; U. S. Kim, None.

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Corresponding author: Ungsoo Samuel Kim

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Kim, K.H., Kim, U.S. Efficacy of N95 amplitude of pattern electroretinogram measured from baseline to N95 trough in the traumatic optic neuropathy. Jpn J Ophthalmol 63, 284–288 (2019). https://doi.org/10.1007/s10384-019-00664-9

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  • DOI: https://doi.org/10.1007/s10384-019-00664-9

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