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Anti-hyperglycemic and hypolipidemic effects of baechukimchi with Ecklonia cava in type 2 diabetic db/db mice

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Abstract

Anti-hyperglycemic and hypolipidemic effects of baechukimchi with Ecklonia cava were investigated in type 2 diabetic db/db mice. Baechukimchi with 15% added E. cava (BKE) was fermented at 5°C for 28 days to obtain optimally ripened BKE (pH 4.28, acidity 0.71). BKE was subjected to extraction using 80% methanol. Male db/db mice were divided into groups of db/db-control, db/db-BKE, and db/db-rosiglitazone (db/db-RG). Compounds were orally administered every day for 6 weeks. The db/db-BKE mice had lowered blood glucose and plasma insulin levels. Plasma total cholesterol, triglyceride, and LDL-cholesterol levels in db/db-BKE mice were significantly (p<0.05) decreased, compared with untreated db/db mice, while db/db-BKE mice had significantly (p<0.05) increased HDL-cholesterol levels. The db/db-BKE mice had significantly (p<0.05) decreased levels of liver total cholesterol and triglyceride. BKE significantly (p<0.05) increased antioxidant enzyme activities, and ROS and lipid peroxidation levels were significantly (p<0.05) lower in db/db-BKE mice than in db/db mice.

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Authors and Affiliations

  1. Department of Food Science and Nutrition, Pusan National University, Busan, 609-735, Korea

    Hyun-Ah Lee, Yeong-Ok Song & Ji-Sook Han

  2. Department of Food Science and Nutrition, College of Medical and Life Science, Silla University, Busan, 617-736, Korea

    Mi-hwa Park

  3. Food and Safety Research Center, National Fisheries Research & Development Institute, Busan, 619-705, Korea

    Mi-Soon Jang

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  1. Hyun-Ah Lee
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Correspondence to Ji-Sook Han.

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Lee, HA., Park, Mh., Song, YO. et al. Anti-hyperglycemic and hypolipidemic effects of baechukimchi with Ecklonia cava in type 2 diabetic db/db mice. Food Sci Biotechnol 24, 307–314 (2015). https://doi.org/10.1007/s10068-015-0041-z

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  • DOI: https://doi.org/10.1007/s10068-015-0041-z

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