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Anti- hyperglycemic effect of aqueous extract of Kappaphycus alvarezii (Doty) Doty ex. P. Silva in alloxan-induced diabetic rats

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Abstract

The intake of food and control of blood glucose levels are very important in diabetic patients. α-Glucosidase inhibitors are a cost-effective means to prevent the progression of diabetes. To find a natural inhibitor from seaweed with anti-hyperglycemic effects, methanolic extract of a red seaweed, Kappaphycus alvarezii (Doty) Doty ex P. Silva, which contains complex mixtures of various types of bioactive compounds which have a hypoglycaemic effect was evaluated in alloxan-induced diabetic rats by using two different doses (200 and 400 mg kg−1 body weight). Blood glucose, glycosylated haemoglobin, haemoglobin, serum lipids of total cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-C), phospholipids, low density lipoprotein (LDL) and plasma insulin were examined in control and seaweed extract-treated experimental rats. The aqueous extract was orally administered for 28 days. The results showed that the aqueous extract of K. alvarezii significantly (p < 0.05) reduced blood glucose level and restored glycosylated haemoglobin and plasma insulin. These results demonstrate that K. alvarezii can be used as a health food and has strong anti-diabetic effects in vivo; thus, it may have beneficial properties in the prevention of diabetes and could be useful in the development of anti-diabetic drugs.

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Acknowledgments

The authors express their sincere thanks to Dr. Sr. A. Jospin Nirmala Mary, the Principal of Fatima College, Madurai, for her keen interest in this study and providing facilities to carry out the experiments. They also thank Dr. C. R. K. Reddy, Group leader, seaweed cultivation group, CSIR-CSMCRI for valuable suggestions in improve the manuscript and support in field cultivation work. The authors would also like to thank Dr. N. Chidambaranathan, M. Pharm. Ph.D., Vice Principal, K.M. College of Pharmacy, Uthangudi, Madurai, for giving permission to carry out the research in their institution. The contribution has CSIR-CSMCRI PRIS registration number 093/2015.

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Authors and Affiliations

  1. Department of Zoology, Fatima college, Madurai, 6250 017, India

    Biji Cyriac

  2. Marine Algal Research Station, CSIR-Central Salt & Marine Chemicals Research Institute, Mandapam Camp, 623 519, India

    K. Eswaran

  3. Academy of Scientific and Innovative Research (AcSIR), CSIR, New Delhi, 110 001, India

    K. Eswaran

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  1. Biji Cyriac
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Cyriac, B., Eswaran, K. Anti- hyperglycemic effect of aqueous extract of Kappaphycus alvarezii (Doty) Doty ex. P. Silva in alloxan-induced diabetic rats. J Appl Phycol 28, 2507–2513 (2016). https://doi.org/10.1007/s10811-015-0762-7

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