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Insights into the multifunctional roles of geminivirus-encoded proteins in pathogenesis

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Abstract

Geminiviruses are a major threat to agriculture in tropical and subtropical regions of the world. Geminiviruses have small genome with limited coding capacity. Despite this limitation, these viruses have mastered hijacking the host cellular metabolism for their survival. To compensate for the small size of their genome, geminiviruses encode multifunctional proteins. In addition, geminiviruses associate themselves with satellite DNA molecules which also encode proteins that support the virus in establishing successful infection. Geminiviral proteins recruit multiple host factors, suppress the host defense, and manipulate host metabolism to establish infection. We have updated the knowledge accumulated about the proteins of geminiviruses and their satellites in the context of pathogenesis in a single review. We also discuss their interactions with host factors to provide a mechanistic understanding of the infection process.

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Acknowledgements

We gratefully acknowledge the financial support from the Department of Biotechnology, Govt of India, DBT BUILDER (SLS/BUILDER/SC/2021) and DST-FIST II (SLS/FIST-II/SC/2021). We also thank Malavika M for critically reading the manuscript.

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  1. Molecular Virology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India

    Ragunathan Devendran, Tsewang Namgial, Kishore Kumar Reddy, Manish Kumar, Fauzia Zarreen & Supriya Chakraborty

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  1. Ragunathan Devendran
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Devendran, R., Namgial, T., Reddy, K.K. et al. Insights into the multifunctional roles of geminivirus-encoded proteins in pathogenesis. Arch Virol 167, 307–326 (2022). https://doi.org/10.1007/s00705-021-05338-x

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