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Modification of L-DOPA pharmacological activity by MAO inhibitors

  • Amine oxidases and disease
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Summary

Dopamine behaves mainly as a MAO-A substrate in rodent brain, but selective inhibition of MAO-B results in an increased turning activity following L-DOPA administration in hemi-Parkinsonian rodents. Unilateral substantia nigra dopaminergic denervation results in serotonergic hyper-innervation which may increase the contribution of MAO-A in the denervated striatum. Possibly as a result of this, there was no change in striatal MAO-A activity when 95% of dopaminergic innervation was reduced by 6-hydroxydopamine, as assessed by apomorphine-induced turning activity. MAO-B as well as MAO-A may contribute to deamination of dopamine produced from L-DOPA.

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Abbreviations

AAADC:

aromatic amino-acid decarboxylase

COMT:

catechol-O-methyltransferase

DA:

dopamine

5,7-DHT:

5,7-dihydroxytryptamine

5-HT:

5-hydroxytryptamine

L-DOPA:

L-3,4-dihydroxyphenylalanine

LID:

L-DOPA-induced dyskinesias

MAO:

monoamine oxidase

6-OHDA:

6-hydroxydopamine

PD:

Parkinson’s disease

2-PEA:

2-phenylethylamine

snpc:

substantia nigra pars compacta

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  1. Pharmacology Department, Rappaport Faculty of Medicine, Technion, Haifa, Israel

    J. P. M. Finberg & O. Sader-Mazbar

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  1. J. P. M. Finberg
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Finberg, J., Sader-Mazbar, O. Modification of L-DOPA pharmacological activity by MAO inhibitors. J Neural Transm 114, 801–805 (2007). https://doi.org/10.1007/s00702-007-0691-y

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