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Association between acute kidney injury and brain injury on term-equivalent age brain magnetic resonance imaging in very preterm infants

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Abstract

Background

This study aimed to investigate the relationship between acute kidney injury (AKI) in the first 2 weeks of life and brain injury on term-equivalent age magnetic resonance imaging in very preterm infants.

Methods

We included 116 infants with a birth weight of < 1500 g who were born at the King Saud Medical City at ≤ 32 gestational weeks. They were admitted to the neonatal intensive care unit and underwent term-equivalent age and pre-discharge brain magnetic resonance imaging. A negative binomial with generalized linear models and a robust variance estimator (Huber–White) was applied for univariate relative risk analysis. The Kidokoro score was then used to determine the effect of AKI on brain morphology and growth at term-equivalent age.

Results

Sixty-eight (64.2%) infants had developed an AKI in the first 2 weeks of life. AKI was significantly associated with cerebellum signal abnormalities, cerebellar volume reduction, and a high total cerebellum score (P = 0.04, P < 0.001, P < 0.001, respectively).

Conclusions

AKI in the first 2 weeks of life is associated with brain insult, especially in the cerebellum. More well-designed studies are required to investigate the association and impact of AKI on the central nervous system.

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Author information

Authors and Affiliations

  1. Neonatal Intensive Care, Hospital of Paediatrics, King Saud Medical City, Al Imam Abdul Aziz Ibn Muhammad Ibn Saud, Riyadh, 12746, Saudi Arabia

    Mountasser M. Al-Mouqdad, Ayman T. Abdalgader & Waleed S. Ameen

  2. Radiology and Medical Imaging Department, College of Medicine, King Saud University, Riyadh, Saudi Arabia

    Dima Z. Jamjoom

  3. Obstetric and Gynecology Department, Maternity Hospital, King Saud Medical City, Riyadh, Saudi Arabia

    Thanaa M. Khalil

  4. Obstetric and Gynecology Department, Family Care Hospital, Riyadh, Saudi Arabia

    Yasmeen S. Asfour

  5. Pharmacy Department, Pharmaceutical Care Services, King Saud Medical City, Riyadh, Saudi Arabia

    Maha R. Al-Anazi

  6. Clinical Pharmacy Department, Pharmaceutical Care Services, King Saud Medical City, Riyadh, Saudi Arabia

    Suzan S. Asfour

Authors
  1. Mountasser M. Al-Mouqdad
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  2. Dima Z. Jamjoom
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  3. Ayman T. Abdalgader
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  4. Waleed S. Ameen
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  5. Thanaa M. Khalil
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  6. Yasmeen S. Asfour
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  7. Maha R. Al-Anazi
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  8. Suzan S. Asfour
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Contributions

Dr. Mountasser designed the study and wrote the manuscript. Dr. Suzan analyzed the data, wrote the methods and results, and created the figures and tables. Dr. Dima reviewed the images and interpreted the results. Drs. Thanaa and Yasmeen collected the data. Drs. Ayman, Waleed, and Maha shared in writing the manuscript. All authors critically revised and approved the final version of the manuscript.

Corresponding author

Correspondence to Mountasser M. Al-Mouqdad.

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Al-Mouqdad, M.M., Jamjoom, D.Z., Abdalgader, A.T. et al. Association between acute kidney injury and brain injury on term-equivalent age brain magnetic resonance imaging in very preterm infants. Pediatr Nephrol 37, 3235–3242 (2022). https://doi.org/10.1007/s00467-022-05534-0

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  • DOI: https://doi.org/10.1007/s00467-022-05534-0

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