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Primary hyperoxalurias: diagnosis and treatment

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Abstract

Primary hyperoxalurias (PH) comprise a group of three distinct metabolic diseases caused by derangement of glyoxylate metabolism in the liver. Recent years have seen advances in several aspects of PH research. This paper reviews current knowledge of the genetic and biochemical basis of PH, the specific epidemiology and clinical presentation of each type, and therapeutic approaches in different disease stages. Potential future specific therapies are discussed.

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Acknowledgments

The authors are indebted to Dr. Ruth Belostotsky for designing Fig. 2.

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Authors and Affiliations

  1. Division of Pediatric Nephrology, Shaare Zedek Medical Center, P.O.Box 3235, Jerusalem, Israel

    Efrat Ben-Shalom & Yaacov Frishberg

  2. The Hebrew University School of Medicine, Jerusalem, Israel

    Yaacov Frishberg

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  1. Efrat Ben-Shalom
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  2. Yaacov Frishberg
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Correspondence to Yaacov Frishberg.

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Answers

1. d

2. c

3. c

4. a

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Ben-Shalom, E., Frishberg, Y. Primary hyperoxalurias: diagnosis and treatment. Pediatr Nephrol 30, 1781–1791 (2015). https://doi.org/10.1007/s00467-014-3030-1

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  • DOI: https://doi.org/10.1007/s00467-014-3030-1

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