Abu-Ghanem Y, Cohen H, Buskila Y, Grauer E, Amitai Y (2008) Enhanced stress reactivity in nitric oxide synthase type 2 mutant mice: findings in support of astrocytic nitrosative modulation of behavior. Neurosci 156:257–265
Article
CAS
Google Scholar
Adachi M, Barrot M, Autry AE, Theobald D, Monteggia LM (2008) Selective loss of brain-derived neurotrophic factor in the dentate gyrus attenuates antidepressant efficacy. Biol Psychiatry 63:642–649
Article
CAS
PubMed
Google Scholar
Alda M, McKinnon M, Blagdon R, Garnham J, MacLellan S, O’Donovan C, Hajek T, Nair C, Dursun S, MacQueen G (2017) Methylene blue treatment for residual symptoms of bipolar disorder: randomised crossover study. Br J Psychiatry 210:54–60
Article
PubMed
Google Scholar
Amitai Y (2010) Physiologic role for “inducible” nitric oxide synthase: a new form of astrocytic-neuronal interface. Glia 58:1775–1781
Article
PubMed
Google Scholar
Arevalo R, Sanchez F, Alonso JR, Carretero J, Vazquez R, Aijon J (1992) NADPH-diaphorase activity in the hypothalamic magnocellular neurosecretory nuclei of the rat. Brain Res Bull 28:599–603
Article
CAS
PubMed
Google Scholar
Autry AE, Monteggia LM (2012) Brain-derived neurotrophic factor and neuropsychiatric disorders. Pharmacol Rev 64:238–258
Article
CAS
PubMed
PubMed Central
Google Scholar
Badenhorst NJ, Brand L, Harvey BH, Ellis SM, Brink CB (2017) Long-term effects of pre-pubertal fluoxetine on behaviour and monoaminergic stress response in stress-sensitive rats. Acta Neuropsychiatr 29:222–235
Article
PubMed
Google Scholar
Bauer MB, Murphy S, Gebhart GF (1994) Muscarinic cholinergic stimulation of the nitric oxide-cyclic GMP signaling system in cultured rat sensory neurons. Neurosci 62:351–359
Article
CAS
Google Scholar
Bernstein HG, Stanarius A, Baumann B, Henning H, Krell D, Danos P, Falkai P, Bogerts B (1998) Nitric oxide synthase-containing neurons in the human hypothalamus: reduced number of immunoreactive cells in the paraventricular nucleus of depressive patients and schizophrenics. Neurosci 83:867–875
Article
CAS
Google Scholar
Bernstein HG, Heinemann A, Krell D, Mawrin C, Bielau H, Danos P, Diekmann S, Keilhoff G, Bogerts B, Baumann B (2002) Further immunohistochemical evidence for impaired NO signaling in the hypothalamus of depressed patients. Ann N Y Acad Sci 973:91–93
Article
CAS
PubMed
Google Scholar
Bhat G, Mahesh VB, Aguan K, Brann DW (1996) Evidence that brain nitric oxide synthase is the major nitric oxide synthase isoform in the hypothalamus of the adult female rat and that nitric oxide potently regulates hypothalamic cGMP levels. Neuroendocrinology 64:93–102
Article
CAS
PubMed
Google Scholar
Biojone C, Casarotto PC, Joca SR, Castren E (2015) Interplay between nitric oxide and brain-derived neurotrophic factor in neuronal plasticity. CNS Neurol Disord Drug Targets 14:979–987
Article
CAS
PubMed
Google Scholar
Bodini P (1899) Le bleu de méthylène comme calmant chez le aliénés. La Semaine Médicale 56
Bollinger JL, Collins KE, Patel R, Wellman CL (2017) Behavioral stress alters corticolimbic microglia in a sex- and brain region-specific manner. PLoS One 12:e0187631
Article
CAS
PubMed
PubMed Central
Google Scholar
Borda T, Genaro A, Sterin-Borda L, Cremaschi G (1998) Involvement of endogenous nitric oxide signalling system in brain muscarinic acetylcholine receptor activation. J Neural Transm (Vienna) 105:193–204
Article
CAS
Google Scholar
Brand SJ, Harvey BH (2017a) Exploring a post-traumatic stress disorder paradigm in Flinders sensitive line rats to model treatment-resistant depression I: bio-behavioural validation and response to imipramine. Acta Neuropsychiatr 29:193–206
Article
PubMed
Google Scholar
Brand SJ, Harvey BH (2017b) Exploring a post-traumatic stress disorder paradigm in Flinders sensitive line rats to model treatment-resistant depression II: response to antidepressant augmentation strategies. Acta Neuropsychiatr 29:207–221
Article
PubMed
Google Scholar
Bugajski J, Gadek-Michalska A, Bugajski AJ (2004) Nitric oxide and prostaglandin systems in the stimulation of hypothalamic-pituitary-adrenal axis by neurotransmitters and neurohormones. J Physiol Pharmacol 55:679–703
CAS
PubMed
Google Scholar
Buskila Y, Abu-Ghanem Y, Levi Y, Moran A, Grauer E, Amitai Y (2007) Enhanced astrocytic nitric oxide production and neuronal modifications in the neocortex of a NOS2 mutant mouse. PLoS One 2:e843
Article
CAS
PubMed
PubMed Central
Google Scholar
Cai C-Y, Chen C, Zhou Y, Han Z, Qin C, Cao B, Tao Y, Bian X-L, Lin Y-H, Chang L, Wu H-Y, Luo C-X, Zhu D-Y (2018) PSD-95-nNOS coupling regulates contextual fear extinction in the Dorsal CA3. Sci Rep 8:12775
Article
CAS
PubMed
PubMed Central
Google Scholar
Canossa M, Giordano E, Cappello S, Guarnieri C, Ferri S (2002) Nitric oxide down-regulates brain-derived neurotrophic factor secretion in cultured hippocampal neurons. Proc Natl Acad Sci U S A 99:3282–3287
Article
CAS
PubMed
PubMed Central
Google Scholar
Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, McClay J, Mill J, Martin J, Braithwaite A, Poulton R (2003) Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301:386–389
Article
CAS
PubMed
Google Scholar
Ceccatelli S, Grandison L, Scott REM, Pfaff DW, Kow LM (1996) Estradiol regulation of nitric oxide synthase mRNAs in rat hypothalamus. Neuroendocrinology 64:357–363
Article
CAS
PubMed
Google Scholar
Chang C-K, Hayes RD, Perera G, Broadbent MTM, Fernandes AC, Lee WE, Hotopf M, Stewart R (2011) Life expectancy at birth for people with serious mental illness and other major disorders from a secondary mental health care case register in London. PLoS One 6:e19590
Article
CAS
PubMed
PubMed Central
Google Scholar
Chanrion B, Mannoury la Cour C, Bertaso F, Lerner-Natoli M, Freissmuth M, Millan MJ, Bockaert J, Marin P (2007) Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity. Proc Natl Acad Sci U S A 104:8119–8124
Article
CAS
PubMed
PubMed Central
Google Scholar
Cheng A, Wang S, Cai J, Rao MS, Mattson MP (2003) Nitric oxide acts in a positive feedback loop with BDNF to regulate neural progenitor cell proliferation and differentiation in the mammalian brain. DevBiol 258:319–333
CAS
Google Scholar
Chisholm D, Sweeny K, Sheehan P, Rasmussen B, Smit F, Cuijpers P, Saxena S (2016) Scaling-up treatment of depression and anxiety: a global return on investment analysis. Lancet Psychiatry 3:415–424
Article
PubMed
Google Scholar
Chong CM, Ai N, Ke M, Tan Y, Huang Z, Li Y, Lu JH, Ge W, Su H (2018) Roles of nitric oxide synthase isoforms in neurogenesis. Mol Neurobiol 55:2645–2652
Article
CAS
PubMed
Google Scholar
Cipriani A, Furukawa TA, Salanti G, Chaimani A, Atkinson LZ, Ogawa Y, Leucht S, Ruhe HG, Turner EH, Higgins JPT, Egger M, Takeshima N, Hayasaka Y, Imai H, Shinohara K, Tajika A, Ioannidis JPA, Geddes JR (2018) Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis. Lancet 391:1357–1366
Article
CAS
PubMed
PubMed Central
Google Scholar
Costa A, Trainer P, Besser M, Grossman A (1993) Nitric oxide modulates the release of corticotropin-releasing hormone from the rat hypothalamus in vitro. Brain Res 605:187–192
Article
CAS
PubMed
Google Scholar
Delport A, Harvey BH, Petzer A, Petzer JP (2017) Methylene blue and its analogues as antidepressant compounds. Metab Brain Dis 32:1357–1382
Article
CAS
PubMed
Google Scholar
Delport A, Harvey BH, Petzer A, Petzer JP (2018) Methylene blue analogues with marginal monoamine oxidase inhibition retain antidepressant-like activity. ACS Chem Neurosci
Dhir A, Kulkarni SK (2007) Involvement of nitric oxide (NO) signaling pathway in the antidepressant action of bupropion, a dopamine reuptake inhibitor. Eur J Pharmacol 568:177–185
Article
CAS
PubMed
Google Scholar
Ding JD, Burette A, Nedvetsky PI, Schmidt HH, Weinberg RJ (2004) Distribution of soluble guanylyl cyclase in the rat brain. J Comp Neurol 472:437–448
Article
CAS
PubMed
Google Scholar
Diniz CR, Casarotto PC, Joca SR (2016) NMDA-NO signaling in the dorsal and ventral hippocampus time-dependently modulates the behavioral responses to forced swimming stress. Behav Brain Res 307:126–136
Article
CAS
PubMed
Google Scholar
Doucet MV, Levine H, Dev KK, Harkin A (2013) Small-molecule inhibitors at the PSD-95/nNOS interface have antidepressant-like properties in mice. Neuropsychopharmacol 38:1575–1584
Article
CAS
Google Scholar
Doucet MV, O’Toole E, Connor T, Harkin A (2015) Small-molecule inhibitors at the PSD-95/nNOS interface protect against glutamate-induced neuronal atrophy in primary cortical neurons. Neurosci 301:421–438
Article
CAS
Google Scholar
Dulawa SC, Janowsky DS (2018) Cholinergic regulation of mood: from basic and clinical studies to emerging therapeutics. Mol Psychiatry
Duman RS, Aghajanian GK (2012) Synaptic dysfunction in depression: potential therapeutic targets. Science 338:68–72
Article
CAS
PubMed
PubMed Central
Google Scholar
Duman RS, Malberg J, Nakagawa S (2001a) Regulation of adult neurogenesis by psychotropic drugs and stress. J Pharmacol Exp Ther 299:401–407
CAS
PubMed
Google Scholar
Duman RS, Nakagawa S, Malberg J (2001b) Regulation of adult neurogenesis by antidepressant treatment. Neuropsychopharmacol 25:836–844
Article
CAS
Google Scholar
Duman RS, Aghajanian GK, Sanacora G, Krystal JH (2016) Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants. Nat Med 22:238
Article
CAS
PubMed
PubMed Central
Google Scholar
Ehninger D, Kempermann G (2008) Neurogenesis in the adult hippocampus. Cell Tissue Res 331:243–250
Article
PubMed
Google Scholar
Ehringer H, Hornykiewicz O, Lechner K (1961) Die Wirkung von Methylenblau auf die Monoaminoxydase und den Katecholamin-und 5-Hydroxytryptaminstoffwechsel des Gehirnes. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol 241:568–582
Article
CAS
PubMed
Google Scholar
Eraldemir FC, Ozsoy D, Bek S, Kir H, Dervisoglu E (2015) The relationship between brain-derived neurotrophic factor levels, oxidative and nitrosative stress and depressive symptoms: a study on peritoneal dialysis. Ren Fail 37:722–726
Article
CAS
PubMed
Google Scholar
Fassini A, Antero LS, Corrêa FMA, Joca SR, Resstel LBM (2015) The prelimbic cortex muscarinic M3 receptor–nitric oxide–guanylyl cyclase pathway modulates cardiovascular responses in rats. 93:830-838
Feil R, Kleppisch T (2008) NO/cGMP-dependent modulation of synaptic transmission. Handb Exp Pharmacol:529–560
Finkel MS, Laghrissi-Thode F, Pollock BG, Rong J (1996) Paroxetine is a novel nitric oxide synthase inhibitor. Psychopharmacol Bull 32:653–658
CAS
PubMed
Google Scholar
Florenzano F, Viscomi MT, Amadio S, D’Ambrosi N, Volonte C, Molinari M (2008) Do ATP and NO interact in the CNS? Prog Neurobiol 84:40–56
Article
CAS
PubMed
Google Scholar
Fossier P, Blanchard B, Ducrocq C, Leprince C, Tauc L, Baux G (1999) Nitric oxide transforms serotonin into an inactive form and this affects neuromodulation. Neurosci 93:597–603
Article
CAS
Google Scholar
Gądek-Michalska A, Tadeusz J, Rachwalska P, Bugajski J (2016) Psychosocial stress inhibits additional stress-induced hyperexpression of NO synthases and IL-1β in brain structures. Pharmacol Rep 68:1178–1196
Article
CAS
PubMed
Google Scholar
Galecki P, Maes M, Florkowski A, Lewinski A, Galecka E, Bienkiewicz M, Szemraj J (2011) Association between inducible and neuronal nitric oxide synthase polymorphisms and recurrent depressive disorder. J Affect Disord 129:175–182
Article
CAS
PubMed
Google Scholar
Garthwaite J (2008) Concepts of neural nitric oxide-mediated transmission. Eur J Neurosci 27:2783–2802
Article
PubMed
PubMed Central
Google Scholar
Garthwaite J, Charles SL, Chess-Williams R (1988) Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain. Nature 336:385–388
Article
CAS
PubMed
Google Scholar
Ghasemi M, Sadeghipour H, Mosleh A, Sadeghipour HR, Mani AR, Dehpour AR (2008) Nitric oxide involvement in the antidepressant-like effects of acute lithium administration in the mouse forced swimming test. Eur Neuropsychopharmacol 18:323–332
Article
CAS
PubMed
Google Scholar
Gilhotra N, Dhingra D (2009) Involvement of NO–cGMP pathway in anti-anxiety effect of aminoguanidine in stressed mice. Prog Neuro-Psychopharmacol Biol Psychiatry 33:1502–1507
Article
CAS
Google Scholar
Gillman PK (2008) Methylene blue is a potent monoamine oxidase inhibitor. Can J Anaesth 55:311–312 author reply 312
Article
PubMed
Google Scholar
Givalois L, Li S, Pelletier G (2002) Central nitric oxide regulation of the hypothalamic-pituitary-adrenocortical axis in adult male rats. Mol Brain Res 102:1–8
Article
CAS
PubMed
Google Scholar
Gray WP, Cheung A (2014) Chapter four—nitric oxide regulation of adult neurogenesis. In: Litwack G (ed) Vitamins & hormones, vol 96. Academic Press, pp 59-77
Guix FX, Uribesalgo I, Coma M, Munoz FJ (2005) The physiology and pathophysiology of nitric oxide in the brain. Prog Neurobiol 76:126–152
Article
CAS
PubMed
Google Scholar
Hardingham N, Dachtler J, Fox K (2013) The role of nitric oxide in pre-synaptic plasticity and homeostasis. Front Cell Neurosci 7:190
Article
CAS
PubMed
PubMed Central
Google Scholar
Harkin AJ, Bruce KH, Craft B, Paul IA (1999) Nitric oxide synthase inhibitors have antidepressant-like properties in mice. 1. Acute treatments are active in the forced swim test. Eur J Pharmacol 372:207–213
Article
CAS
PubMed
Google Scholar
Harkin A, Connor TJ, Walsh M, St John N, Kelly JP (2003) Serotonergic mediation of the antidepressant-like effects of nitric oxide synthase inhibitors. Neuropharmacol 44:616–623
Article
CAS
Google Scholar
Harkin A, Connor TJ, Burns MP, Kelly JP (2004) Nitric oxide synthase inhibitors augment the effects of serotonin re-uptake inhibitors in the forced swimming test. Eur Neuropsychopharmacol 14:274–281
Article
CAS
PubMed
Google Scholar
Harraz MM, Tyagi R, Cortes P, Snyder SH (2016) Antidepressant action of ketamine via mTOR is mediated by inhibition of nitrergic Rheb degradation. Mol Psychiatry 21:313–319
Article
CAS
PubMed
PubMed Central
Google Scholar
Harvey BH, Oosthuizen F, Brand L, Wegener G, Stein DJ (2004) Stress-restress evokes sustained iNOS activity and altered GABA levels and NMDA receptors in rat hippocampus. Psychopharmacol (Berl) 175:494–502
Article
CAS
Google Scholar
Harvey BH, Bothma T, Nel A, Wegener G, Stein DJ (2005) Involvement of the NMDA receptor, NO-cyclic GMP and nuclear factor K-beta in an animal model of repeated trauma. Hum Psychopharmacol 20:367–373
Article
CAS
PubMed
Google Scholar
Hasin DS, Sarvet AL, Meyers JL et al (2018) Epidemiology of adult dsm-5 major depressive disorder and its specifiers in the United States. JAMA Psychiatry 75:336–346
Article
PubMed
PubMed Central
Google Scholar
Heiberg IL, Wegener G, Rosenberg R (2002) Reduction of cGMP and nitric oxide has antidepressant-like effects in the forced swimming test in rats. Behav Brain Res 134:479–484
Article
CAS
PubMed
Google Scholar
Herken H, Gurel A, Selek S, Armutcu F, Ozen ME, Bulut M, Kap O, Yumru M, Savas HA, Akyol O (2007) Adenosine deaminase, nitric oxide, superoxide dismutase, and xanthine oxidase in patients with major depression: impact of antidepressant treatment. Arch Med Res 38:247–252
Article
CAS
PubMed
Google Scholar
Hiroaki-Sato VA, Sales AJ, Biojone C, Joca SR (2014) Hippocampal nNOS inhibition induces an antidepressant-like effect: involvement of 5HT1A receptors. Behav Pharmacol 25:187–196
Article
CAS
PubMed
Google Scholar
Hölscher C (1997) Nitric oxide, the enigmatic neuronal messenger: its role in synaptic plasticity. Trends Neurosci 20:298–303
Article
PubMed
Google Scholar
Islam ATMS, Kuraoka A, Kawabuchi M JASI(2003) Morphological basis of nitric oxide production and its correlation with the polysialylated precursor cells in the dentate gyrus of the adult guinea pig hippocampus. Anat Sci Int 78:98–103
Article
CAS
PubMed
Google Scholar
Izumi Y, Zorumski CF (1993) Nitric oxide and long-term synaptic depression in the rat hippocampus. Neuroreport 4:1131–1134
CAS
PubMed
Google Scholar
Jaffrey SR, Snyder SH (1996) PIN: an associated protein inhibitor of neuronal nitric oxide synthase. Science 274:774–777
Article
CAS
PubMed
Google Scholar
Jaffrey SR, Snowman AM, Eliasson MJ, Cohen NA, Snyder SH (1998) CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95. Neuron 20:115–124
Article
CAS
PubMed
Google Scholar
Jaffrey SR, Erdjument-Bromage H, Ferris CD, Tempst P, Snyder SH (2001) Protein S-nitrosylation: a physiological signal for neuronal nitric oxide. Nat Cell Biol 3:193–197
Article
CAS
PubMed
Google Scholar
Jakubovic A, Necina J (1963) The effect of methylene blue on the monoamine oxidase activity of the liver and brain of rats after various routes of administration. Arzneimittelforschung 13:134–136
CAS
PubMed
Google Scholar
Jesse CR, Bortolatto CF, Savegnago L, Rocha JB, Nogueira CW (2008) Involvement of L-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of tramadol in the rat forced swimming test. Prog Neuro-Psychopharmacol Biol Psychiatry 32:1838–1843
Article
CAS
Google Scholar
Joca SR, Guimaraes FS (2006) Inhibition of neuronal nitric oxide synthase in the rat hippocampus induces antidepressant-like effects. Psychopharmacol (Berl) 185:298–305
Article
CAS
Google Scholar
Joca SR, Guimaraes FS, Del-Bel E (2007) Inhibition of nitric oxide synthase increases synaptophysin mRNA expression in the hippocampal formation of rats. Neurosci Lett 421:72–76
Article
CAS
PubMed
Google Scholar
Joca S, Biojone C, Casarotto P, Montezuma K, Cunha F, Guimaraes F (2012) BDNF-TrkB signaling is involved in the antidepressant-like effect induced by genetic deletion of iNOS. Int J Neuropsychopharmacol 15:44–45
Google Scholar
Kaehler ST, Singewald N, Sinner C, Philippu A (1999) Nitric oxide modulates the release of serotonin in the rat hypothalamus. Brain Res 835:346–349
Article
CAS
PubMed
Google Scholar
Karolewicz B, Szebeni K, Stockmeier CA, Konick L, Overholser JC, Jurjus G, Roth BL, Ordway GA (2004) Low nNOS protein in the locus coeruleus in major depression. J Neurochem 91:1057–1066
Article
CAS
PubMed
PubMed Central
Google Scholar
Kendler KS, Thornton LM, Gardner CO (2000) Stressful life events and previous episodes in the etiology of major depression in women: an evaluation of the ‘kindling’ hypothesis. AJ Psychiatry 157:1243–1251
CAS
Google Scholar
Kessler RC, Bromet EJ (2013) The epidemiology of depression across cultures. Annu Rev Public Health 34:119–138
Article
PubMed
PubMed Central
Google Scholar
Kim YK, Paik JW, Lee SW, Yoon D, Han C, Lee BH (2006) Increased plasma nitric oxide level associated with suicide attempt in depressive patients. Prog Neuro-Psychopharmacol Biol Psychiatry 30:1091–1096
Article
CAS
Google Scholar
Kleppisch T, Feil R (2009) cGMP Signalling in the mammalian brain: role in synaptic plasticity and behaviour. In: Schmidt HHHW, Hofmann F, Stasch JP (eds) cGMP: generators, effectors and therapeutic implications. Handbook of Experimental Pharmacology, 191:549-79. Springer, Berlin, Heidelberg
Kolarow R, Kuhlmann CR, Munsch T, Zehendner C, Brigadski T, Luhmann HJ, Lessmann V (2014) BDNF-induced nitric oxide signals in cultured rat hippocampal neurons: time course, mechanism of generation, and effect on neurotrophin secretion. Front Cell Neurosci 8:323
Article
CAS
PubMed
PubMed Central
Google Scholar
Krass M, Wegener G, Vasar E, Volke V (2008) Antidepressant-like effect of agmatine is not mediated by serotonin. Behav Brain Res 188:324–328
Article
CAS
PubMed
Google Scholar
Krass M, Runkorg K, Wegener G, Volke V (2010) Nitric oxide is involved in the regulation of marble-burying behavior. Neurosci Lett 480:55–58
Article
CAS
PubMed
Google Scholar
Krass M, Wegener G, Vasar E, Volke V (2011) The antidepressant action of imipramine and venlafaxine involves suppression of nitric oxide synthesis. Behav Brain Res 218:57–63
Article
CAS
PubMed
Google Scholar
Kuhn DM, Arthur RE Jr (1996) Inactivation of brain tryptophan hydroxylase by nitric oxide. J Neurochem 67:1072–1077
Article
CAS
PubMed
Google Scholar
Kuhn DM, Arthur R Jr (1997) Molecular mechanism of the inactivation of tryptophan hydroxylase by nitric oxide: attack on critical sulfhydryls that spare the enzyme iron center. J Neurosci 17:7245–7251
Article
CAS
PubMed
PubMed Central
Google Scholar
Lassen LH, Ashina M, Christiansen I, Ulrich V, Olesen J (1997) Nitric oxide synthase inhibition in migraine [letter]. Lancet 349:401–402
Article
CAS
PubMed
Google Scholar
Lassen LH, Ashina M, Christiansen I, Ulrich V, Grover R, Donaldson J, Olesen J (1998) Nitric oxide synthase inhibition: a new principle in the treatment of migraine attacks. Cephalalgia 18:27–32
Article
CAS
PubMed
Google Scholar
Lasserre AM, Marti-Soler H, Strippoli M-PF, Vaucher J, Glaus J, Vandeleur CL, Castelao E, Marques-Vidal P, Waeber G, Vollenweider P, Preisig M (2016) Clinical and course characteristics of depression and all-cause mortality: a prospective population-based study. J Affect Disord 189:17–24
Article
PubMed
Google Scholar
Laursen TM, Musliner KL, Benros ME, Vestergaard M, Munk-Olsen T (2016) Mortality and life expectancy in persons with severe unipolar depression. J Affect Disord 193:203–207
Article
PubMed
Google Scholar
Leal G, Bramham CR, Duarte CB (2017) Chapter eight—BDNF and hippocampal synaptic plasticity. In: Litwack G (ed) Vitamins and hormones, vol 104. Academic Press, pp 153-195
Lee BH, Lee SW, Yoon D, Lee HJ, Yang JC, Shim SH, Kim DH, Ryu SH, Han C, Kim YK (2006) Increased plasma nitric oxide metabolites in suicide attempters. Neuropsychobiology 53:127–132
Article
CAS
PubMed
Google Scholar
Lescai F, Als TD, Li Q, Nyegaard M, Andorsdottir G, Biskopstø M, Hedemand A, Fiorentino A, O’Brien N, Jarram A, Liang J, Grove J, Pallesen J, Eickhardt E, Mattheisen M, Bolund L, Demontis D, Wang AG, McQuillin A, Mors O, Wang J, Børglum AD (2017) Whole-exome sequencing of individuals from an isolated population implicates rare risk variants in bipolar disorder. Transl Psychiatry 7:e1034
Article
CAS
PubMed
PubMed Central
Google Scholar
Levy MJF, Boulle F, Steinbusch HW, van den Hove DLA, Kenis G, Lanfumey LJP (2018) Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression. Psychopharmacology (Berl) 235:2195–2220
Article
CAS
Google Scholar
Li Y-F, Zhang Y-Z, Liu Y-Q, Wang H-L, Cao J-B, Guan T-T, Luo Z-P (2006) Inhibition of N-methyl-D-aspartate receptor function appears to be one of the common actions for antidepressants. J Psychopharmacol 20:629–635
Article
CAS
PubMed
Google Scholar
Liebenberg N, Joca S, Wegener G (2015) Nitric oxide involvement in the antidepressant-like effect of ketamine in the Flinders sensitive line rat model of depression. Acta Neuropsychiatr 27:90–96
Article
PubMed
Google Scholar
Lisboa SF, Gomes FV, Silva AL, Uliana DL, Camargo LH, Guimaraes FS, Cunha FQ, Joca SR, Resstel LB (2015) Increased contextual fear conditioning in iNOS knockout mice: additional evidence for the involvement of nitric oxide in stress-related disorders and contribution of the endocannabinoid system. Int J Neuropsychopharmacol 18(8):pyv005. https://doi.org/10.1093/ijnp/pyv005
Lonart G, Johnson KM (1994) Inhibitory effects of nitric oxide on the uptake of [3H]dopamine and [3H]glutamate by striatal synaptosomes. J Neurochem 63:2108–2117
Article
CAS
PubMed
Google Scholar
Lonart G, Cassels KL, Johnson KM (1993) Nitric oxide induces calcium-dependent [3H]dopamine release from striatal slices. J NeurosciRes 35:192–198
CAS
Google Scholar
Lorrain DS, Hull EM (1993) Nitric oxide increases dopamine and serotonin release in the medial preoptic area. Neuroreport 5:87–89
Article
CAS
PubMed
Google Scholar
Luo C-X, Jin X, Cao C-C, Zhu M-M, Wang B, Chang L, Zhou Q-G, Wu H-Y, Zhu D-Y (2010) BIdirectional regulation of neurogenesis by neuronal nitric oxide synthase derived from neurons and neural stem cells. 28:2041–2052
Madrigal JL, Moro MA, Lizasoain I, Lorenzo P, Castrillo A, Bosca L, Leza JC (2001) Inducible nitric oxide synthase expression in brain cortex after acute restraint stress is regulated by nuclear factor kappaB-mediated mechanisms. J Neurochem 76:532–538
Article
CAS
PubMed
Google Scholar
Madrigal JLM, Moro MA, Lizasoain I, Lorenzo P, Leza JC (2002) Stress-induced increase in extracellular sucrose space in rats is mediated by nitric oxide. Brain Res 938:87–91
Article
CAS
PubMed
Google Scholar
Mancuso C, Navarra P, Preziosi P (2010) Roles of nitric oxide, carbon monoxide, and hydrogen sulfide in the regulation of the hypothalamic-pituitary-adrenal axis. J Neurochem 113:563–575
Article
CAS
PubMed
Google Scholar
Manji HK, Moore GJ, Rajkowska G, Chen G (2000) Neuroplasticity and cellular resilience in mood disorders. Mol Psychiatry 5:578–593
Article
CAS
PubMed
Google Scholar
Manji HK, Drevets WC, Charney DS (2001) The cellular neurobiology of depression. NatMed 7:541–547
CAS
Google Scholar
Manucha W (2017) Mitochondrial dysfunction associated with nitric oxide pathways in glutamate neurotoxicity. Clínica e Investigación en Arteriosclerosis 29:92–97
Article
PubMed
Google Scholar
Marcoli M, Maura G, Tortarolo M, Raiteri M (1997) Serotonin inhibition of the NMDA receptor/nitric oxide/cyclic GMP pathway in rat cerebellum: involvement of 5-hydroxytryptamine2C receptors. J Neurochem 69:427–430
Article
CAS
PubMed
Google Scholar
Matarredona ER, Murillo-Carretero M, Moreno-López B, Estrada C (2004) Nitric oxide synthesis inhibition increases proliferation of neural precursors isolated from the postnatal mouse subventricular zone. Brain Res 995:274–284
Article
CAS
PubMed
Google Scholar
Meffert MK, Premack BA, Schulman H (1994) Nitric oxide stimulates Ca(2+)-independent synaptic vesicle release. Neuron 12:1235–1244
Article
CAS
PubMed
Google Scholar
Meffert MK, Calakos NC, Scheller RH, Schulman H (1996) Nitric oxide modulates synaptic vesicle docking fusion reactions. Neuron 16:1229–1236
Article
CAS
PubMed
Google Scholar
Mizoguchi Y, Kato TA, Seki Y, Ohgidani M, Sagata N, Horikawa H, Yamauchi Y, Sato-Kasai M, Hayakawa K, Inoue R, Kanba S, Monji A (2014) Brain-derived neurotrophic factor (BDNF) induces sustained intracellular Ca2+ elevation through the up-regulation of surface transient receptor potential 3 (TRPC3) channels in rodent microglia. J Biol Chem 289:18549–18555
Article
CAS
PubMed
PubMed Central
Google Scholar
Montezuma K, Biojone C, Lisboa SF, Cunha FQ, Guimaraes FS, Joca SR (2012) Inhibition of iNOS induces antidepressant-like effects in mice: pharmacological and genetic evidence. Neuropharmacol 62:485–491
Article
CAS
Google Scholar
Mutlu O, Ulak G, Laugeray A, Belzung C (2009) Effects of neuronal and inducible NOS inhibitor 1-[2-(trifluoromethyl) phenyl] imidazole (TRIM) in unpredictable chronic mild stress procedure in mice. Pharmacol Biochem Behav 92:82–87
Article
CAS
PubMed
Google Scholar
Naylor GJ, Martin B, Hopwood SE, Watson Y (1986) A two-year double-blind crossover trial of the prophylactic effect of methylene blue in manic-depressive psychosis. Biol Psychiatry 21:915–920
Article
CAS
PubMed
Google Scholar
Naylor GJ, Smith AH, Connelly P (1987) A controlled trial of methylene blue in severe depressive illness. Biol Psychiatry 22:657–659
Article
CAS
PubMed
Google Scholar
Naylor GJ, Smith AH, Connelly P (1988) Methylene blue in mania [letter]. Biol Psychiatry 24:941–942
Article
CAS
PubMed
Google Scholar
Nelson RJ, Trainor BC, Chiavegatto S, Demas GE (2006) Pleiotropic contributions of nitric oxide to aggressive behavior. Neurosci Biobehav Rev 30:346–355
Article
CAS
PubMed
Google Scholar
Nikonenko I, Boda B, Steen S, Knott G, Welker E, Muller D (2008) PSD-95 promotes synaptogenesis and multiinnervated spine formation through nitric oxide signaling. 183:1115–1127
Nikonenko I, Nikonenko A, Mendez P, Michurina TV, Enikolopov G, Muller D (2013) Nitric oxide mediates local activity-dependent excitatory synapse development. 110:E4142-E4151
Nylén A, Skagerberg G, Alm P, Larsson B, Holmqvist B, Andersson KE (2001) Nitric oxide synthase in the hypothalamic paraventricular nucleus of the female rat; organization of spinal projections and coexistence with oxytocin or vasopressin. Brain Res 908:10–24
Article
PubMed
Google Scholar
Okada S, Murakami Y, Yokotani K (2002) Centrally applied nitric oxide donor elevates plasma corticosterone by activation of the hypothalamic noradrenergic neurons in rats. Brain Res 939:26–33
Article
CAS
PubMed
Google Scholar
Okumura T, Kishi T, Okochi T, Ikeda M, Kitajima T, Yamanouchi Y, Kinoshita Y, Kawashima K, Tsunoka T, Inada T, Ozaki N, Iwata N (2010) Genetic association analysis of functional polymorphisms in neuronal nitric oxide synthase 1 gene (NOS1) and mood disorders and fluvoxamine response in major depressive disorder in the Japanese population. Neuropsychobiology 61:57–63
Article
CAS
PubMed
Google Scholar
Olesen J, Leonardi M (2003) The burden of brain diseases in Europe. Eur J Neurol 10:471–477
Article
CAS
PubMed
Google Scholar
Olesen J, Sobscki P, Truelsen T, Sestoft D, Jonsson B (2008) Cost of disorders of the brain in Denmark. NordJ Psychiatry 62:114–120
Article
Google Scholar
Oliveira RM, Guimaraes FS, Deakin JF (2008) Expression of neuronal nitric oxide synthase in the hippocampal formation in affective disorders. Braz J Med Biol Res 41:333–341
Article
CAS
PubMed
Google Scholar
Packer MA, Stasiv Y, Benraiss A, Chmielnicki E, Grinberg A, Westphal H, Goldman SA, Enikolopov G (2003) Nitric oxide negatively regulates mammalian adult neurogenesis. Proc Natl Acad Sci U S A 100:9566–9571
Article
CAS
PubMed
PubMed Central
Google Scholar
Park S-Y, Kang M-J, Han J-SJMN (2017) Neuronal NOS induces neuronal differentiation through a PKCα-dependent GSK3β inactivation pathway in hippocampal neural progenitor cells. Mol Neurobiol 54:5646–5656
Article
CAS
PubMed
Google Scholar
Pereira VS, Casarotto PC, Hiroaki-Sato VA, Sartim AG, Guimaraes FS, Joca SR (2013) Antidepressant- and anticompulsive-like effects of purinergic receptor blockade: involvement of nitric oxide. Eur Neuropsychopharmacol 23:1769–1778
Article
CAS
PubMed
Google Scholar
Pereira VS, Romano A, Wegener G, Joca SR (2015) Antidepressant-like effects induced by NMDA receptor blockade and NO synthesis inhibition in the ventral medial prefrontal cortex of rats exposed to the forced swim test. Psychopharmacol (Berl) 232(13):2263–2273
Article
CAS
Google Scholar
Petzer A, Harvey BH, Wegener G, Petzer JP (2012) Azure B, a metabolite of methylene blue, is a high-potency, reversible inhibitor of monoamine oxidase. Toxicol Appl Pharmacol 258:403–409
Article
CAS
PubMed
Google Scholar
Pinnock SB, Herbert J (2008) Brain-derived neurotropic factor and neurogenesis in the adult rat dentate gyrus: interactions with corticosterone. Eur J Neurosci 27:2493–2500
Article
PubMed
PubMed Central
Google Scholar
Pittenger C, Duman RS (2008) Stress, depression, and neuroplasticity: a convergence of mechanisms. Neuropsychopharmacol 33:88–109
Article
CAS
Google Scholar
Pogun S, Kuhar MJ (1994) Regulation of neurotransmitter reuptake by nitric oxide. Ann N Y Acad Sci 738(305–15):305–315
CAS
PubMed
Google Scholar
Pogun S, Baumann MH, Kuhar MJ (1994a) Nitric oxide inhibits [3H]dopamine uptake. Brain Res 641:83–91
Article
CAS
PubMed
Google Scholar
Pogun S, Dawson V, Kuhar MJ (1994b) Nitric oxide inhibits 3H-glutamate transport in synaptosomes. Synapse 18:21–26
Article
CAS
PubMed
Google Scholar
Rabinovich D, Yaniv Shiri P, Alyagor I, Schuldiner O (2016) Nitric oxide as a switching mechanism between axon degeneration and regrowth during developmental remodeling. Cell 164:170–182
Article
CAS
PubMed
PubMed Central
Google Scholar
Raiteri M, Maura G, Barzizza A (1991) Activation of presynaptic 5-hydroxytryptamine1-like receptors on glutamatergic terminals inhibits N-methyl-D-aspartate-induced cyclic GMP production in rat cerebellar slices. JPharmacolExpTher 257:1184–1188
CAS
Google Scholar
Rivier C (2001) Role of gaseous neurotransmitters in the hypothalamic-pituitary-adrenal axis. Ann N Y Acad Sci 933:254–264
Article
CAS
PubMed
Google Scholar
Rivier C (2003) Role of nitric oxide in regulating the rat hypothalamic-pituitary-adrenal axis response to endotoxemia. Ann N Y Acad Sci 992:72–85
Article
CAS
PubMed
Google Scholar
Rivier C, Shen GH (1994a) In the rat, endogenous nitric oxide modulates the response of the hypothalamic-pituitary-adrenal axis to interleukin-1 beta, vasopressin, and oxytocin. J Neurosci 14:1985–1993
Article
CAS
PubMed
PubMed Central
Google Scholar
Rivier C, Shen GH (1994b) In the rat, endogenous nitric oxide modulates the response of the hypothalamic-pituitary-adrenal axis to interleukin-1β, vasopressin, and oxytocin. J Neurosci 14:1985–1993
Article
CAS
PubMed
PubMed Central
Google Scholar
Romero-Grimaldi C, Moreno-López B, Estrada C (2008) Age-dependent effect of nitric oxide on subventricular zone and olfactory bulb neural precursor proliferation. J Comp Neurol 506:339–346
Article
CAS
PubMed
Google Scholar
Salehpour M, Khodagholi F, Zeinaddini Meymand A, Nourshahi M, Ashabi G (2017) Exercise training with concomitant nitric oxide synthase inhibition improved anxiogenic behavior, spatial cognition, and BDNF/P70S6 kinase activation in 20-month-old rats. Appl Physiol Nutr Metab 43:45–53
Article
CAS
PubMed
Google Scholar
Sales AJ, Hiroaki-Sato VA, Joca SR (2017) Participation of hippocampal nitric oxide synthase and soluble guanylate cyclase in the modulation of behavioral responses elicited by the rat forced swimming test. Behav Pharmacol 28:19–29
Article
CAS
PubMed
Google Scholar
Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S, Weisstaub N, Lee J, Duman R, Arancio O, Belzung C, Hen R (2003) Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301:805–809
Article
CAS
PubMed
Google Scholar
Segovia G, Porras A, Mora F (1994) Effects of a nitric oxide donor on glutamate and GABA release in striatum and hippocampus of the conscious rat. Neuroreport 5:1937–1940
Article
CAS
PubMed
Google Scholar
Segovia G, Del Arco A, Mora F (1997) Endogenous glutamate increases extracellular concentrations of dopamine, GABA, and taurine through NMDA and AMPA/kainate receptors in striatum of the freely moving rat: a microdialysis study. J Neurochem 69:1476–1483
Article
CAS
PubMed
Google Scholar
Segovia G, Del Arco A, Mora F (1999) Role of glutamate receptors and glutamate transporters in the regulation of the glutamate-glutamine cycle in the awake rat. NeurochemRes 24:779–783
CAS
Google Scholar
Seo DO, Rivier C (2001) Microinfusion of a nitric oxide donor in discrete brain regions activates the hypothalamic-pituitary-adrenal axis. J Neuroendocrinol 13:925–933
Article
CAS
PubMed
Google Scholar
Silva Pereira V, Elfving B, Joca SRL, Wegener G (2017) Ketamine and aminoguanidine differentially affect Bdnf and Mtor gene expression in the prefrontal cortex of adult male rats. Eur J Pharmacol 815:304–311
Article
CAS
PubMed
Google Scholar
Silva M, Aguiar DC, Diniz CR, Guimaraes FS, Joca SR (2012) Neuronal NOS inhibitor and conventional antidepressant drugs attenuate stress-induced fos expression in overlapping brain regions. Cell Mol Neurobiol 32:443–453
Article
CAS
PubMed
Google Scholar
Spalding KL, Bergmann O, Alkass K, Bernard S, Salehpour M, Huttner HB, Boström E, Westerlund I, Vial C, Buchholz BA, Possnert G, Mash DC, Druid H, Frisén J (2013) Dynamics of hippocampal neurogenesis in adult humans. Cell 153:X1219–X1227
Article
CAS
Google Scholar
Spiacci A Jr, Kanamaru F, Guimaraes FS, Oliveira RM (2008) Nitric oxide-mediated anxiolytic-like and antidepressant-like effects in animal models of anxiety and depression. Pharmacol Biochem Behav 88:247–255
Article
CAS
PubMed
Google Scholar
Srivastava N, Barthwal MK, Dalal PK, Agarwal AK, Nag D, Seth PK, Srimal RC, Dikshit M (2002) A study on nitric oxide, beta-adrenergic receptors and antioxidant status in the polymorphonuclear leukocytes from the patients of depression. J Affect Disord 72:45–52
Article
CAS
PubMed
Google Scholar
Stanford SC, Stanford BJ, Gillman PK (2009) Risk of severe serotonin toxicity following co-administration of methylene blue and serotonin reuptake inhibitors: an update on a case report of post-operative delirium. J Psychopharmacol (Oxf) 24(10):1433–1438
Article
CAS
Google Scholar
Stanquini LA, Biojone C, Guimaraes FS, Joca SR (2018) Repeated treatment with nitric oxide synthase inhibitor attenuates learned helplessness development in rats and increases hippocampal BDNF expression. Acta Neuropsychiatr 30:127–136
Article
PubMed
Google Scholar
Strasser A, McCarron RM, Ishii H, Stanimirovic D, Spatz M (1994) L-arginine induces dopamine release from the striatum in vivo. Neuroreport 5:2298–2300
Article
CAS
PubMed
Google Scholar
Sullivan PF, de Geus EJ, Willemsen G, …, Penninx BW (2009) Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo. Mol Psychiatry 14:359–375
Sunico CR, Portillo F, Gonzalez-Forero D, Moreno-Lopez B (2005) Nitric-oxide-directed synaptic remodeling in the adult mammal CNS. J Neurosci 25:1448–1458
Article
CAS
PubMed
PubMed Central
Google Scholar
Suzuki E, Yagi G, Nakaki T, Kanba S, Asai M (2001) Elevated plasma nitrate levels in depressive states. J Affect Disord 63:221–224
Article
CAS
PubMed
Google Scholar
Suzuki E, Yoshida Y, Shibuya A, Miyaoka H (2003) Nitric oxide involvement in depression during interferon-alpha therapy. Int J Neuropsychopharmacol 6:415–419
Article
CAS
PubMed
Google Scholar
Swaab DF, Bao A-M, Lucassen PJ (2005) The stress system in the human brain in depression and neurodegeneration. Ageing Res Rev 4:141–194
Article
CAS
PubMed
Google Scholar
Tanda K, Nishi A, Matsuo N, Nakanishi K, Yamasaki N, Sugimoto T, Toyama K, Takao K, Miyakawa T (2009) Abnormal social behavior, hyperactivity, impaired remote spatial memory, and increased D1-mediated dopaminergic signaling in neuronal nitric oxide synthase knockout mice. Mol Brain 2:19
Article
CAS
PubMed
PubMed Central
Google Scholar
Tang J, Yu W, Chen S, Gao Z, Xiao B (2018) Microglia polarization and endoplasmic reticulum stress in chronic social defeat stress induced depression mouse. Neurochem Res 43:985–994
Article
CAS
PubMed
Google Scholar
Thomsen LL (1997) Investigations into the role of nitric oxide and the large intracranial arteries in migraine headache. Cephalalgia 17:873–895
Article
CAS
PubMed
Google Scholar
Thomsen LL, Olesen J (1998) Nitric oxide theory of migraine. Clin Neurosci 5:28–33
Article
CAS
PubMed
Google Scholar
Tillmann S, Pereira VS, Liebenberg N, Christensen AK, Wegener G (2017) ZL006, a small molecule inhibitor of PSD-95/nNOS interaction, does not induce antidepressant-like effects in two genetically predisposed rat models of depression and control animals. PLoS One 12:e0182698
Article
CAS
PubMed
PubMed Central
Google Scholar
Tsuchiya T, Kishimoto J, Koyama J, Ozawa T (1997) Modulatory effect of L-NAME, a specific nitric oxide synthase (NOS) inhibitor, on stress-induced changes in plasma adrenocorticotropic hormone (ACTH) and corticosterone levels in rats: physiological significance of stress-induced NOS activation in hypothalamic-pituitary-adrenal axis. Brain Res 776:68–74
Article
CAS
PubMed
Google Scholar
Volke V, Wegener G, Vasar E, Rosenberg R (1999) Methylene blue inhibits hippocampal nitric oxide synthase activity in vivo. Brain Res 826:303–305
Article
CAS
PubMed
Google Scholar
Volke V, Wegener G, Bourin M, Vasar E (2003) Antidepressant- and anxiolytic-like effects of selective neuronal NOS inhibitor 1-(2-trifluoromethylphenyl)-imidazole in mice. Behav Brain Res 140:141–147
Article
CAS
PubMed
Google Scholar
Volonte C, Apolloni S, Skaper SD, Burnstock G (2012) P2X7 receptors: channels, pores and more. CNS Neurol Disord Drug Targets 11:705–721
Article
CAS
PubMed
Google Scholar
Vorherr T, Knoepfel L, Hofmann F, Mollner S, Pfeuffer T, Carafoli E (1993) The calmodulin binding domain of nitric oxide synthase and adenylyl cyclase. Biochemistry (Mosc) 32:6081–6088
Article
CAS
Google Scholar
Vos T, Abajobir AA, Abate KH, […], Murray CJL (2017) Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet 390:1211–1259
Wallerath T, Gath I, Aulitzky WE, Pollock JS, Kleinert H, Förstermann U (1997) Identification of the NO synthase isoforms expressed in human neutrophil granulocytes, megakaryocytes and platelets. Thromb Haemost 77:163–167
Article
CAS
PubMed
Google Scholar
Wegener G, Rujescu D (2013) The current development of CNS drug research. Int J Neuropsychopharmacol 16:1687–1693
Article
PubMed
Google Scholar
Wegener G, Volke V (2010) Nitric oxide synthase inhibitors as antidepressants. Pharmaceuticals 3:273–299
Article
CAS
PubMed
PubMed Central
Google Scholar
Wegener G, Volke V, Rosenberg R (2000) Endogenous nitric oxide decreases hippocampal levels of serotonin and dopamine in vivo. Br J Pharmacol 130:575–580
Article
CAS
PubMed
PubMed Central
Google Scholar
Wegener G, Volke V, Harvey BH, Rosenberg R (2003) Local, but not systemic, administration of serotonergic antidepressants decreases hippocampal nitric oxide synthase activity. Brain Res 959:128–134
Article
CAS
PubMed
Google Scholar
Wegener G, Harvey BH, Bonefeld B, Muller HK, Volke V, Overstreet DH, Elfving B (2010) Increased stress-evoked nitric oxide signalling in the Flinders sensitive line (FSL) rat: a genetic animal model of depression. Int J Neuropsychopharmacol 13:461–473
Article
CAS
PubMed
Google Scholar
Weitzdoerfer R, Hoeger H, Engidawork E, Engelmann M, Singewald N, Lubec G, Lubec B (2004) Neuronal nitric oxide synthase knock-out mice show impaired cognitive performance. Nitric Oxide 10:130–140
Article
CAS
PubMed
Google Scholar
Wittchen HU, Jacobi F, Rehm J, Gustavsson A, Svensson M, Jonsson B, Olesen J, Allgulander C, Alonso J, Faravelli C, Fratiglioni L, Jennum P, Lieb R, Maercker A, van Os J, Preisig M, Salvador-Carulla L, Simon R, Steinhausen HC (2011) The size and burden of mental disorders and other disorders of the brain in Europe 2010. Eur Neuropsychopharmacol 21:655–679
Article
CAS
PubMed
Google Scholar
Xing G, Chavko M, Zhang LX, Yang S, Post RM (2002) Decreased calcium-dependent constitutive nitric oxide synthase (cNOS) activity in prefrontal cortex in schizophrenia and depression. Schizophr Res 58:21–30
Article
PubMed
Google Scholar
Xiong H, Yamada K, Han D, Nabeshima T, Enikolopov G, Carnahan J, Nawa H (1999) Mutual regulation between the intercellular messengers nitric oxide and brain-derived neurotrophic factor in rodent neocortical neurons. Eur J Neurosci 11:1567–1576
Article
CAS
PubMed
Google Scholar
Yazir Y, Utkan T, Aricioglu F (2012) Inhibition of neuronal nitric oxide synthase and soluble guanylate cyclase prevents depression-like behaviour in rats exposed to chronic unpredictable mild stress. Basic Clin Pharmacol Toxicol 111:154–160
CAS
PubMed
Google Scholar
Yildiz F, Erden BF, Ulak G, Utkan T, Gacar N (2000) Antidepressant-like effect of 7-nitroindazole in the forced swimming test in rats. Psychopharmacol (Berl) 149:41–44
Article
CAS
Google Scholar
Yu YW, Chen TJ, Wang YC, Liou YJ, Hong CJ, Tsai SJ (2003) Association analysis for neuronal nitric oxide synthase gene polymorphism with major depression and fluoxetine response. Neuropsychobiology 47:137–140
Article
CAS
PubMed
Google Scholar
Yuen EC, Gunther EC, Bothwell M (2000) Nitric oxide activation of TrkB through peroxynitrite. Neuroreport 11:3593–3597
Article
CAS
PubMed
Google Scholar
Zaragoza C, Ocampo C, Saura M, Leppo M, Wei XQ, Quick R, Moncada S, Liew FY, Lowenstein CJ (1998) The role of inducible nitric oxide synthase in the host response to Coxsackievirus myocarditis. Proc Natl Acad Sci U S A 95:2469–2474
Article
CAS
PubMed
PubMed Central
Google Scholar
Zaragoza C, Ocampo CJ, Saura M, Bao C, Leppo M, Lafond-Walker A, Thiemann DR, Hruban R, Lowenstein CJ (1999) Inducible nitric oxide synthase protection against coxsackievirus pancreatitis. J Immunol 163:5497–5504
CAS
PubMed
Google Scholar
Zhang G-F, Wang N, Shi J-Y, Xu S-X, Li X-M, Ji M-H, Zuo Z-Y, Zhou Z-Q, Yang J-J (2013) Inhibition of the l-arginine–nitric oxide pathway mediates the antidepressant effects of ketamine in rats in the forced swimming test. Pharmacol Biochem Behav 110:8–12
Article
CAS
PubMed
Google Scholar
Zhao M, Chen L, Yang J, Han D, Fang D, Qiu X, Yang X, Qiao Z, Ma J, Wang L, Jiang S, Song X, Zhou J, Zhang J, Chen M, Qi D, Yang Y, Pan H (2018) BDNF Val66Met polymorphism, life stress and depression: a meta-analysis of gene-environment interaction. J Affect Disord 227:226–235
Article
CAS
PubMed
Google Scholar
Zhou QG, Hu Y, Hua Y, Hu M, Luo CX, Han X, Zhu XJ, Wang B, Xu JS, Zhu DY (2007) Neuronal nitric oxide synthase contributes to chronic stress-induced depression by suppressing hippocampal neurogenesis. J Neurochem 103:1843–1854
Article
CAS
PubMed
Google Scholar
Zhou L, Li F, Xu HB, Luo CX, Wu HY, Zhu MM, Lu W, Ji X, Zhou QG, Zhu DY (2010) Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95. Nat Med 16:1439–1443
Article
CAS
PubMed
Google Scholar
Zhou QG, Zhu LJ, Chen C, Wu HY, Luo CX, Chang L, Zhu DY (2011) Hippocampal neuronal nitric oxide synthase mediates the stress-related depressive behaviors of glucocorticoids by downregulating glucocorticoid receptor. J Neurosci 31:7579–7590
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhu XJ, Hua Y, Jiang J, Zhou QG, Luo CX, Han X, Lu YM, Zhu DY (2006) Neuronal nitric oxide synthase-derived nitric oxide inhibits neurogenesis in the adult dentate gyrus by down-regulating cyclic AMP response element binding protein phosphorylation. Neurosci 141:827–836
Article
CAS
Google Scholar
Zorumski CF, Izumi Y (1993) Nitric oxide and hippocampal synaptic plasticity. Biochem Pharmacol 46:777–785
Article
CAS
PubMed
Google Scholar