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Fragmentation of the Golgi apparatus of the ballooned neurons in patients with corticobasal degeneration and Creutzfeldt-Jakob disease

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Abstract

We investigated immunohistologically the Golgi apparatus (GA) and the trans-Golgi network (TGN) of the cortical ballooned neurons (BNs) in two patients with corticobasal degeneration and in five with Creutzfeldt-Jakob disease. We observed that the BNs showed fragmentation of the GA and the TGN, accompanied by a reduction in the number of fragmented Golgi elements and by a unique perinuclear distribution. This is the first report of the abnormalities of GA in cortical BNs. These findings suggests that the GA and the TGN may play some roles in the BN formation.

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Authors and Affiliations

  1. Department of Neurology, Gunma University School of Medicine, Maebashi, Gunma 371-8511, Japan Tel.: +81-27-2208061, Fax: +81-27-2208067, , , , , , JP

    A. Sakurai, K. Okamoto & Y. Fujita

  2. Department of Pathology, Gunma University School of Medicine, Maebashi, Gunma 371-8511, Japan, , , , , , JP

    Y. Nakazato

  3. Brain Disease Research Center, Brain Research Institute, Niigata University, Niigata 951-8585, Japan, , , , , , JP

    K. Wakabayashi

  4. Department of Pathology, Brain Research Institute, Niigata University, Niigata 951-8585, Japan, , , , , , JP

    H. Takahashi

  5. Department of Pathology and Laboratory Medicine, 418 Johnson Pavilion, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6079, USA, , , , , , US

    N. K. Gonatas

Authors
  1. A. Sakurai
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  2. K. Okamoto
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  3. Y. Fujita
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  4. Y. Nakazato
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  5. K. Wakabayashi
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  6. H. Takahashi
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  7. N. K. Gonatas
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Additional information

Received: 1 September 1999 / Revised, accepted: 30 November 1999

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Sakurai, A., Okamoto, K., Fujita, Y. et al. Fragmentation of the Golgi apparatus of the ballooned neurons in patients with corticobasal degeneration and Creutzfeldt-Jakob disease. Acta Neuropathol 100, 270–274 (2000). https://doi.org/10.1007/s004010000182

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  • DOI: https://doi.org/10.1007/s004010000182

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