Amaral AI, Hadera MG, Kotter M, Sonnewald U (2017) Oligodendrocytes do not export NAA-derived aspartate in vitro. Neurochem Res 42:827–837. https://doi.org/10.1007/s11064-016-1985-y
Article
Google Scholar
Ahmed SS, Li H, Cao C, Sikoglu EM, Denninger AR, Su Q, Eaton S, Liso Navarro AA, Xie J, Szucs S et al (2013) A single intravenous rAAV injection as late as P20 achieves efficacious and sustained CNS gene therapy in Canavan mice. Mol Ther 21:2136–2147. https://doi.org/10.1038/mt.2013.138
CAS
Article
PubMed
PubMed Central
Google Scholar
Ahmed SS, Schattgen SA, Frakes AE, Sikoglu EM, Su Q, Li J, Hampton TG, Denninger AR, Kirschner DA, Kaspar B et al (2016) raav gene therapy in a Canavan’s disease mouse model reveals immune impairments and an extended pathology beyond the central nervous system. Mol Ther 24:1030–1041. https://doi.org/10.1038/mt.2016.68
CAS
Article
PubMed
PubMed Central
Google Scholar
Appu AP, Moffett JR, Arun P, Moran S, Nambiar V, Krishnan JKS, Puthillathu N, Namboodiri AMA (2017) Increasing N-acetylaspartate in the brain during postnatal myelination does not cause the CNS pathologies of Canavan disease. Front Mol Neurosci 10:161. https://doi.org/10.3389/fnmol.2017.00161
Article
PubMed
PubMed Central
Google Scholar
Banerjee R, Vitvitsky V, Garg SK (2008) The undertow of sulfur metabolism on glutamatergic neurotransmission. Trends Biochem Sci 33:413–419. https://doi.org/10.1016/j.tibs.2008.06.006
CAS
Article
PubMed
Google Scholar
Baslow MH (2002) Evidence supporting a role for N-acetyl-l-aspartate as a molecular water pump in myelinated neurons in the central nervous system. An analytical review. Neurochem Int 40:295–300
CAS
Article
PubMed
Google Scholar
Becker I, Lodder J, Gieselmann V, Eckhardt M (2010) Molecular characterization of N-acetylaspartylglutamate synthetase. J Biol Chem 285:29156–29164. https://doi.org/10.1074/jbc.M110.111765
CAS
Article
PubMed
PubMed Central
Google Scholar
Bothwell JH, Rae C, Dixon RM, Styles P, Bhakoo KK (2001) Hypo-osmotic swelling-activated release of organic osmolytes in brain slices: implications for brain oedema in vivo. J Neurochem 77:1632–1640
CAS
Article
PubMed
Google Scholar
Burri R, Steffen C, Herschkowitz N (1991) N-acetyl-l-aspartate is a major source of acetyl groups for lipid synthesis during rat brain development. Dev Neurosci 13:403–411
CAS
Article
PubMed
Google Scholar
Cahoy JD, Emery B, Kaushal A, Foo LC, Zamanian JL, Christopherson KS, Xing Y, Lubischer JL, Krieg PA, Krupenko SA et al (2008) A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function. J Neurosci 28:264–278. https://doi.org/10.1523/JNEUROSCI.4178-07.2008
CAS
Article
PubMed
Google Scholar
Camargo N, Goudriaan A, van Deijk AF, Otte WM, Brouwers JF, Lodder H, Gutmann DH, Nave KA, Dijkhuizen RM, Mansvelder HD et al (2017) Oligodendroglial myelination requires astrocyte-derived lipids. PLoS Biol 15:e1002605. https://doi.org/10.1371/journal.pbio.1002605
Article
PubMed
PubMed Central
Google Scholar
Caroni P (1997) Overexpression of growth-associated proteins in the neurons of adult transgenic mice. J Neurosci Methods 71:3–9
CAS
Article
PubMed
Google Scholar
Chakraborty G, Mekala P, Yahya D, Wu G, Ledeen RW (2001) Intraneuronal N-acetylaspartate supplies acetyl groups for myelin lipid synthesis: evidence for myelin-associated aspartoacylase. J Neurochem 78:736–745
CAS
Article
PubMed
Google Scholar
Chang L, Munsaka SM, Kraft-Terry S, Ernst T (2013) Magnetic resonance spectroscopy to assess neuroinflammation and neuropathic pain. J Neuroimmune Pharmacol 8:576–593. https://doi.org/10.1007/s11481-013-9460-x
Article
PubMed
PubMed Central
Google Scholar
Chen CD, Sloane JA, Li H, Aytan N, Giannaris EL, Zeldich E, Hinman JD, Dedeoglu A, Rosene DL, Bansal R et al (2013) The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS. J Neurosci 33:1927–1939. https://doi.org/10.1523/jneurosci.2080-12.2013
CAS
Article
PubMed
PubMed Central
Google Scholar
Chesler M (2003) Regulation and modulation of pH in the brain. Physiol Rev 83:1183–1221. https://doi.org/10.1152/physrev.00010.2003
CAS
Article
PubMed
Google Scholar
D’Adamo AF Jr, Yatsu FM (1966) Acetate metabolism in the nervous system. N-acetyl-l-aspartic acid and the biosynthesis of brain lipids. J Neurochem 13:961–965
Article
PubMed
Google Scholar
Davies SE, Gotoh M, Richards DA, Obrenovitch TP (1998) Hypoosmolarity induces an increase of extracellular N-acetylaspartate concentration in the rat striatum. Neurochem Res 23:1021–1025
CAS
Article
PubMed
Google Scholar
During MJ, Cao L, Zuzga DS, Francis JS, Fitzsimons HL, Jiao X, Bland RJ, Klugmann M, Banks WA, Drucker DJ et al (2003) Glucagon-like peptide-1 receptor is involved in learning and neuroprotection. Nat Med 9:1173–1179
CAS
Article
PubMed
Google Scholar
Engelhardt B, Vajkoczy P, Weller RO (2017) The movers and shapers in immune privilege of the CNS. Nat Immunol 18:123–131. https://doi.org/10.1038/ni.3666
CAS
Article
PubMed
Google Scholar
Estevez AY, O’Regan MH, Song D, Phillis JW (1999) Hyposmotically induced amino acid release from the rat cerebral cortex: role of phospholipases and protein kinases. Brain Res 844:1–9
CAS
Article
PubMed
Google Scholar
Fedorov A, Beichel R, Kalpathy-Cramer J, Finet J, Fillion-Robin JC, Pujol S, Bauer C, Jennings D, Fennessy F, Sonka M et al (2012) 3D Slicer as an image computing platform for the quantitative imaging network. Magn Reson Imaging 30:1323–1341. https://doi.org/10.1016/j.mri.2012.05.001
Article
PubMed
PubMed Central
Google Scholar
Fisher SK, Novak JE, Agranoff BW (2002) Inositol and higher inositol phosphates in neural tissues: homeostasis, metabolism and functional significance. J Neurochem 82:736–754
CAS
Article
PubMed
Google Scholar
Francis JS, Strande L, Markov V, Leone P (2012) Aspartoacylase supports oxidative energy metabolism during myelination. J Cereb Blood Flow Metab 32:1725–1736. https://doi.org/10.1038/jcbfm.2012.66
CAS
Article
PubMed
PubMed Central
Google Scholar
Francis JS, Wojtas I, Markov V, Gray SJ, McCown TJ, Samulski RJ, Bilaniuk LT, Wang DJ, De Vivo DC, Janson CG et al (2016) N-acetylaspartate supports the energetic demands of developmental myelination via oligodendroglial aspartoacylase. Neurobiol Dis 96:323–334. https://doi.org/10.1016/j.nbd.2016.10.001
CAS
Article
PubMed
PubMed Central
Google Scholar
Frohlich D, Suchowerska AK, Spencer ZH, von Jonquieres G, Klugmann CB, Bongers A, Delerue F, Stefen H, Ittner LM, Fath T et al (2017) In vivo characterization of the aspartyl-tRNA synthetase DARS: homing in on the leukodystrophy HBSL. Neurobiol Dis 97:24–35. https://doi.org/10.1016/j.nbd.2016.10.008
CAS
Article
PubMed
Google Scholar
Gao GP, Alvira MR, Wang L, Calcedo R, Johnston J, Wilson JM (2002) Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy. Proc Natl Acad Sci USA 99:11854–11859
CAS
Article
PubMed
PubMed Central
Google Scholar
Gautier EL, Ivanov S, Williams JW, Huang SC, Marcelin G, Fairfax K, Wang PL, Francis JS, Leone P, Wilson DB et al (2014) Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival. J Exp Med 211:1525–1531. https://doi.org/10.1084/jem.20140570
CAS
Article
PubMed
PubMed Central
Google Scholar
Georgiou E, Sidiropoulou K, Richter J, Papaneophytou C, Sargiannidou I, Kagiava A, von Jonquieres G, Christodoulou C, Klugmann M, Kleopa KA (2017) Gene therapy targeting oligodendrocytes provides therapeutic benefit in a leukodystrophy model. Brain 140:599–616. https://doi.org/10.1093/brain/aww351
PubMed
Google Scholar
Gessler DJ, Gao G (2016) Gene therapy for the treatment of neurological disorders: metabolic disorders. Methods Mol Biol 1382:429–465. https://doi.org/10.1007/978-1-4939-3271-9_30
CAS
Article
PubMed
PubMed Central
Google Scholar
Gessler DJ, Li D, Xu H, Su Q, Sanmiguel J, Tuncer S, Moore C, King J, Matalon R, Gao G (2017) Redirecting N-acetylaspartate metabolism in the central nervous system normalizes myelination and rescues Canavan disease. JCI Insight 2:e90807. https://doi.org/10.1172/jci.insight.90807
Article
PubMed
PubMed Central
Google Scholar
Guo F, Bannerman P, Mills Ko E, Miers L, Xu J, Burns T, Li S, Freeman E, McDonough JA, Pleasure D (2015) Ablating N-acetylaspartate prevents leukodystrophy in a Canavan disease model. Ann Neurol 77:884–888. https://doi.org/10.1002/ana.24392
CAS
Article
PubMed
Google Scholar
Hao S, Tang B, Wu Z, Ure K, Sun Y, Tao H, Gao Y, Patel AJ, Curry DJ, Samaco RC et al (2015) Forniceal deep brain stimulation rescues hippocampal memory in Rett syndrome mice. Nature 526:430–434. https://doi.org/10.1038/nature15694
CAS
Article
PubMed
PubMed Central
Google Scholar
Heilig CW, Stromski ME, Blumenfeld JD, Lee JP, Gullans SR (1989) Characterization of the major brain osmolytes that accumulate in salt-loaded rats. Am J Physiol 257:F1108–F1116
CAS
Article
PubMed
Google Scholar
Hejazi L, Wong JW, Cheng D, Proschogo N, Ebrahimi D, Garner B, Don AS (2011) Mass and relative elution time profiling: two-dimensional analysis of sphingolipids in Alzheimer’s disease brains. Biochem J 438:165–175. https://doi.org/10.1042/BJ20110566
CAS
Article
PubMed
Google Scholar
Ittner LM, Gotz J (2007) Pronuclear injection for the production of transgenic mice. Nat Protoc 2:1206–1215. https://doi.org/10.1038/nprot.2007.145
CAS
Article
PubMed
Google Scholar
Karlsson RM, Tanaka K, Saksida LM, Bussey TJ, Heilig M, Holmes A (2009) Assessment of glutamate transporter GLAST (EAAT1)-deficient mice for phenotypes relevant to the negative and executive/cognitive symptoms of schizophrenia. Neuropsychopharmacology 34:1578–1589. https://doi.org/10.1038/npp.2008.215
CAS
Article
PubMed
Google Scholar
Kaul R, Gao GP, Balamurugan K, Matalon R (1993) Cloning of the human aspartoacylase cDNA and a common missense mutation in Canavan disease. Nat Genet 5:118–123
CAS
Article
PubMed
Google Scholar
Ke YD, van Hummel A, Stevens CH, Gladbach A, Ippati S, Bi M, Lee WS, Kruger S, van der Hoven J, Volkerling A et al (2015) Short-term suppression of A315T mutant human TDP-43 expression improves functional deficits in a novel inducible transgenic mouse model of FTLD-TDP and ALS. Acta Neuropathol 130:661–678. https://doi.org/10.1007/s00401-015-1486-0
CAS
Article
PubMed
Google Scholar
Klugmann M, Leichtlein CB, Symes CW, Serikawa T, Young D, During MJ (2005) Restoration of aspartoacylase activity in CNS neurons does not ameliorate motor deficits and demyelination in a model of Canavan disease. Mol Ther 11:745–753
CAS
Article
PubMed
Google Scholar
Koch M (1999) The neurobiology of startle. Prog Neurobiol 59:107–128
CAS
Article
PubMed
Google Scholar
Kotterman MA, Schaffer DV (2014) Engineering adeno-associated viruses for clinical gene therapy. Nat Rev Genet 15:445–451. https://doi.org/10.1038/nrg3742
CAS
Article
PubMed
PubMed Central
Google Scholar
Kubrusly RC, de Mello MC, de Mello FG (1998) Aspartate as a selective NMDA receptor agonist in cultured cells from the avian retina. Neurochem Int 32:47–52
CAS
Article
PubMed
Google Scholar
Kumar S, Biancotti JC, Matalon R, de Vellis J (2009) Lack of aspartoacylase activity disrupts survival and differentiation of neural progenitors and oligodendrocytes in a mouse model of Canavan disease. J Neurosci Res 87:3415–3427
CAS
Article
PubMed
Google Scholar
Lappe-Siefke C, Goebbels S, Gravel M, Nicksch E, Lee J, Braun PE, Griffiths IR, Nave KA (2003) Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination. Nat Genet 33:366–374
CAS
Article
PubMed
Google Scholar
Le Belle JE, Harris NG, Williams SR, Bhakoo KK (2002) A comparison of cell and tissue extraction techniques using high-resolution 1H-NMR spectroscopy. NMR Biomed 15:37–44
Article
PubMed
Google Scholar
Lehman DM, Harrison JM (2002) Flash visual evoked potentials in the hypomyelinated mutant mouse shiverer. Doc Ophthalmol 104:83–95
Article
PubMed
Google Scholar
Leone P, Shera D, McPhee SW, Francis JS, Kolodny EH, Bilaniuk LT, Wang DJ, Assadi M, Goldfarb O, Goldman HW et al (2012) Long-term follow-up after gene therapy for canavan disease. Sci Trans Med 4:165ra163. https://doi.org/10.1126/scitranslmed.3003454
Article
Google Scholar
Madhavarao CN, Arun P, Moffett JR, Szucs S, Surendran S, Matalon R, Garbern J, Hristova D, Johnson A, Jiang W et al (2005) Defective N-acetylaspartate catabolism reduces brain acetate levels and myelin lipid synthesis in Canavan’s disease. Proc Natl Acad Sci USA 102:5221–5226. https://doi.org/10.1073/pnas.0409184102
CAS
Article
PubMed
PubMed Central
Google Scholar
Madhavarao CN, Moffett JR, Moore RA, Viola RE, Namboodiri MA, Jacobowitz DM (2004) Immunohistochemical localization of aspartoacylase in the rat central nervous system. J Comp Neurol 472:318–329
CAS
Article
PubMed
Google Scholar
Maier H, Wang-Eckhardt L, Hartmann D, Gieselmann V, Eckhardt M (2015) N-Acetylaspartate synthase deficiency corrects the myelin phenotype in a Canavan disease mouse model but does not affect survival time. J Neurosci 35:14501–14516. https://doi.org/10.1523/JNEUROSCI.1056-15.2015
CAS
Article
PubMed
Google Scholar
Martin E, Capone A, Schneider J, Hennig J, Thiel T (2001) Absence of N-acetylaspartate in the human brain: impact on neurospectroscopy? Ann Neurol 49:518–521
CAS
Article
PubMed
Google Scholar
Mehta V, Namboodiri MA (1995) N-Acetylaspartate as an acetyl source in the nervous system. Brain Res Mol Brain Res 31:151–157
CAS
Article
PubMed
Google Scholar
Mersmann N, Tkachev D, Jelinek R, Roth PT, Mobius W, Ruhwedel T, Ruhle S, Weber-Fahr W, Sartorius A, Klugmann M (2011) Aspartoacylase-LacZ Knockin Mice: an engineered model of Canavan disease. PLoS ONE 6:e20336. https://doi.org/10.1371/journal.pone.0020336PONE-D-11-01701
CAS
Article
PubMed
PubMed Central
Google Scholar
Moffett JR, Arun P, Ariyannur PS, Garbern JY, Jacobowitz DM, Namboodiri AM (2011) Extensive aspartoacylase expression in the rat central nervous system. Glia. https://doi.org/10.1002/glia.21186
PubMed
PubMed Central
Google Scholar
Moffett JR, Ross B, Arun P, Madhavarao CN, Namboodiri AM (2007) N-Acetylaspartate in the CNS: from neurodiagnostics to neurobiology. Prog Neurobiol 81:89–131
CAS
Article
PubMed
PubMed Central
Google Scholar
Pessentheiner AR, Pelzmann HJ, Walenta E, Schweiger M, Groschner LN, Graier WF, Kolb D, Uno K, Miyazaki T, Nitta A et al (2013) NAT8L (N-acetyltransferase 8-like) accelerates lipid turnover and increases energy expenditure in brown adipocytes. J Biol Chem 288:36040–36051. https://doi.org/10.1074/jbc.M113.491324
CAS
Article
PubMed
PubMed Central
Google Scholar
Poddar NK, Zano S, Natarajan R, Yamamoto B, Viola RE (2014) Enhanced brain distribution of modified aspartoacylase. Mol Genet Metab 113:219–224. https://doi.org/10.1016/j.ymgme.2014.07.002
CAS
Article
PubMed
PubMed Central
Google Scholar
Prokesch A, Pelzmann HJ, Pessentheiner AR, Huber K, Madreiter-Sokolowski CT, Drougard A, Schittmayer M, Kolb D, Magnes C, Trausinger G et al (2016) N-Acetylaspartate catabolism determines cytosolic acetyl-CoA levels and histone acetylation in brown adipocytes. Sci Rep 6:23723. https://doi.org/10.1038/srep23723
CAS
Article
PubMed
PubMed Central
Google Scholar
Rae CD (2014) A guide to the metabolic pathways and function of metabolites observed in human brain 1H magnetic resonance spectra. Neurochem Res 39:1–36. https://doi.org/10.1007/s11064-013-1199-5
CAS
Article
PubMed
Google Scholar
Rae CD, Davidson JE, Maher AD, Rowlands BD, Kashem MA, Nasrallah FA, Rallapalli SK, Cook JM, Balcar VJ (2014) Ethanol, not detectably metabolized in brain, significantly reduces brain metabolism, probably via action at specific GABA(A) receptors and has measureable metabolic effects at very low concentrations. J Neurochem 129:304–314. https://doi.org/10.1111/jnc.12634
CAS
Article
PubMed
Google Scholar
Rigdon GC (1990) Differential effects of apomorphine on prepulse inhibition of acoustic startle reflex in two rat strains. Psychopharmacology 102:419–421
CAS
Article
PubMed
Google Scholar
Rodriguez CI, Buchholz F, Galloway J, Sequerra R, Kasper J, Ayala R, Stewart AF, Dymecki SM (2000) High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP. Nat Genet 25:139–140
CAS
Article
PubMed
Google Scholar
Sager TN, Fink-Jensen A, Hansen AJ (1997) Transient elevation of interstitial N-acetylaspartate in reversible global brain ischemia. J Neurochem 68:675–682
CAS
Article
PubMed
Google Scholar
Schneider M, Spanagel R, Zhang SJ, Bading H, Klugmann M (2007) Adeno-associated virus (AAV)-mediated suppression of Ca2+/calmodulin kinase IV activity in the nucleus accumbens modulates emotional behaviour in mice. BMC Neurosci 8:105
Article
PubMed
PubMed Central
Google Scholar
Schoenfeld R, Wong A, Silva J, Li M, Itoh A, Horiuchi M, Itoh T, Pleasure D, Cortopassi G (2010) Oligodendroglial differentiation induces mitochondrial genes and inhibition of mitochondrial function represses oligodendroglial differentiation. Mitochondrion 10:143–150. https://doi.org/10.1016/j.mito.2009.12.141
CAS
Article
PubMed
Google Scholar
Simonato M, Bennett J, Boulis NM, Castro MG, Fink DJ, Goins WF, Gray SJ, Lowenstein PR, Vandenberghe LH, Wilson TJ et al (2013) Progress in gene therapy for neurological disorders. Nat Rev Neurol 9:277–291. https://doi.org/10.1038/nrneurol.2013.56
CAS
Article
PubMed
PubMed Central
Google Scholar
Singhal NK, Huang H, Li S, Clements R, Gadd J, Daniels A, Kooijman EE, Bannerman P, Burns T, Guo F et al (2016) The neuronal metabolite NAA regulates histone H3 methylation in oligodendrocytes and myelin lipid composition. Exp Brain Res. https://doi.org/10.1007/s00221-016-4789-z
PubMed
Google Scholar
Sohn J, Bannerman P, Guo F, Burns T, Miers L, Croteau C, Singhal NK, McDonough JA, Pleasure D (2017) Suppressing N-acetyl-l-aspartate synthesis prevents loss of neurons in a murine model of Canavan leukodystrophy. J Neurosci 37:413–421. https://doi.org/10.1523/jneurosci.2013-16.2017
CAS
Article
PubMed
PubMed Central
Google Scholar
Strain GM, Tedford BL (1993) Flash and pattern reversal visual evoked potentials in C57BL/6 J and B6CBAF1/J mice. Brain Res Bull 32:57–63
CAS
Article
PubMed
Google Scholar
Surendran S, Matalon R, Tyring SK (2006) Upregulation of aspartoacylase activity in the duodenum of obesity induced diabetes mouse: implications on diabetic neuropathy. Biochem Biophys Res Commun 11:11
Google Scholar
Taylor DL, Davies SE, Obrenovitch TP, Doheny MH, Patsalos PN, Clark JB, Symon L (1995) Investigation into the role of N-acetylaspartate in cerebral osmoregulation. J Neurochem 65:275–281
CAS
Article
PubMed
Google Scholar
Toriumi K, Kondo M, Nagai T, Hashimoto R, Ohi K, Song Z, Tanaka J, Mouri A, Koseki T, Yamamori H et al (2014) Deletion of SHATI/NAT8L increases dopamine D1 receptor on the cell surface in the nucleus accumbens, accelerating methamphetamine dependence. Int J Neuropsychopharmacol 17:443–453. https://doi.org/10.1017/S1461145713001302
CAS
Article
PubMed
Google Scholar
Tranberg M, Abbas AK, Sandberg M (2007) In vitro studies on the putative function of N-acetylaspartate as an osmoregulator. Neurochem Res 32:1248–1255. https://doi.org/10.1007/s11064-007-9300-6
CAS
Article
PubMed
Google Scholar
Valsamis B, Schmid S (2011) Habituation and prepulse inhibition of acoustic startle in rodents. J Vis Exp. https://doi.org/10.3791/3446
PubMed
PubMed Central
Google Scholar
Verbalis JG (2006) Control of brain volume during hypoosmolality and hyperosmolality. Adv Exp Med Biol 576:113–129. https://doi.org/10.1007/0-387-30172-0_8 (discussion 361–113)
CAS
Article
PubMed
Google Scholar
Videen JS, Michaelis T, Pinto P, Ross BD (1995) Human cerebral osmolytes during chronic hyponatremia. A proton magnetic resonance spectroscopy study. J Clin Invest 95:788–793. https://doi.org/10.1172/jci117728
CAS
Article
PubMed
PubMed Central
Google Scholar
von Jonquieres G, Frohlich D, Klugmann CB, Wen X, Harasta AE, Ramkumar R, Spencer ZH, Housley GD, Klugmann M (2016) Recombinant human myelin-associated glycoprotein promoter drives selective AAV-mediated transgene expression in oligodendrocytes. Front Mol Neurosci 9:13. https://doi.org/10.3389/fnmol.2016.00013
Google Scholar
von Jonquieres G, Froud KE, Klugmann CB, Wong AC, Housley GD, Klugmann M (2014) Loss of central auditory processing in a mouse model of Canavan disease. PLoS ONE 9:e97374. https://doi.org/10.1371/journal.pone.0097374
Article
Google Scholar
von Jonquieres G, Mersmann N, Klugmann CB, Harasta AE, Lutz B, Teahan O, Housley GD, Frohlich D, Kramer-Albers EM, Klugmann M (2013) Glial promoter selectivity following AAV-delivery to the immature brain. PLoS ONE 8:e65646. https://doi.org/10.1371/journal.pone.0065646
Article
Google Scholar
Wang J, Leone P, Wu G, Francis JS, Li H, Jain MR, Serikawa T, Ledeen RW (2009) Myelin lipid abnormalities in the aspartoacylase-deficient tremor rat. Neurochem Res 34:138–148. https://doi.org/10.1007/s11064-008-9726-5
Article
PubMed
Google Scholar
Wibom R, Lasorsa FM, Tohonen V, Barbaro M, Sterky FH, Kucinski T, Naess K, Jonsson M, Pierri CL, Palmieri F et al (2009) AGC1 deficiency associated with global cerebral hypomyelination. N Engl J Med 361:489–495. https://doi.org/10.1056/NEJMoa0900591
Article
PubMed
Google Scholar
Wold S, Antti H, Lindgren F, Ohman J (1998) Orthogonal signal correction of near-infrared spectra. Chemom Intell Lab Syst 44:175–185
CAS
Article
Google Scholar