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Reduced calcium responsiveness characterizes contractile dysfunction following coronary microembolization

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Abstract

Aims

We addressed calcium responsiveness in microembolized myocardium at 6 h after coronary microembolization (ME).

Methods and results

In anesthetized pigs calcium responsiveness was determined as the increase of a myocardial work index (WI; LV pressure development vs. wall thickening) in response to a graded intracoronary infusion of CaCl2 at baseline and at 6 h after ME or placebo, respectively. At baseline, CaCl2 infusion increased WI in both groups (ME: 296 ± 22 to 468 ± 47 mmHg*mm; placebo: 324 ± 24 to 485 ± 38 mmHg*mm; mean ± SEM). At 6 h after ME, WI was decreased by 159 ± 16 mmHg*mm (P < 0.05 vs. baseline) and remained reduced at any calcium concentration, whereas it was unchanged with placebo. The calcium concentration in coronary blood necessary to achieve the half maximal increase in WI remained unchanged from baseline to 6 h and did not differ between placebo and ME.

Conclusion

The ME-induced myocardial dysfunction is not related to an altered calcium sensitivity, but is characterized by a reduced maximal contractile force.

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Acknowledgments

Gerd Heusch was the recipient of a grant from the Deutsche Forschungsgemeinschaft (He 1320/14-1).

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Authors and Affiliations

  1. Institute of Pathophysiology, University School of Medicine, Essen, Germany

    Andreas Skyschally, Petra Gres, Patrick van Caster, Anita van de Sand, Kerstin Boengler, Rainer Schulz &  Gerd Heusch

  2. Institut für Pathophysiologie, Universitätsklinikum Essen, Hufelandstraße 55, 45122, Essen, Germany

    Gerd Heusch

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  1. Andreas Skyschally
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  2. Petra Gres
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  3. Patrick van Caster
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  4. Anita van de Sand
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  5. Kerstin Boengler
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  6. Rainer Schulz
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  7. Gerd Heusch
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Correspondence to Gerd Heusch.

Additional information

Dr. William M. Chilian, Rootstown, USA, served as guest editor for the manuscript and was responsible for all editorial decisions, including the selection of reviewers. The policy applies to all manuscripts with authors from the editor’s institution.

Returned for 1. Revision: 1 May 2008. 1. Revision received: 3 May 2008

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Skyschally, A., Gres, P., van Caster, P. et al. Reduced calcium responsiveness characterizes contractile dysfunction following coronary microembolization. Basic Res Cardiol 103, 552–559 (2008). https://doi.org/10.1007/s00395-008-0732-1

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  • DOI: https://doi.org/10.1007/s00395-008-0732-1

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