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Could a three-dimensional contralateral meniscus segmentation for allograft or scaffold sizing be possible? A prospective study

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Abstract

Purpose

Meniscal allografts and biodegradable meniscal implants are attractive surgical options for painful subtotal or total meniscectomies. In order to get the best results, these should be as similar as possible to the original meniscus in terms of shape, structure, and volume. Three-dimensional meniscus sizing could be an approach to improve the accuracy of meniscus matching. Therefore, the aims of this study were to perform a comparative morphological and volumetric analysis of the healthy meniscus based on manual tri-planar segmentation and to demonstrate that the menisci from the contralateral knee could be used as a reference in the sizing of a meniscal graft or a scaffold.

Methods

Three-dimensional meniscal models were created based on 120 MRIs in 60 healthy subjects (bilateral knees). The differences between the pairs of menisci concerning the widths, thicknesses, lateromedial distances, anteroposterior distances, angles of coverage, and meniscal volumes were evaluated. T-Student tests were used to compare the quantitative numerical variables of the different groups. Pearson’s linear regression was used to determine if correlations existed between demographic variables (age, gender, height, weight) and anatomical parameters. Statistical significance was set at p < 0.05.

Results

Comparing the 120 pairs of menisci of each subject, there was no statistically significant difference for all parameters studied for both the medial and lateral meniscus. When the measurements were stratified by gender, statistically significant differences were observed for all parameters except meniscal coverage angles. We observed that anteroposterior and lateromedial distances were positively correlated with height and body mass index both at the level of the medial meniscus (r = 0.68; r = 0.66; r = 0.65; and r = 0.63) and lateral (r = 0.68; r = 0.69; r = 0.61; and r = 0.60).

Conclusion

Our study demonstrated that the intra-individual 3D shapes of the left and right menisci are very similar. Therefore, the contralateral side could be used as a template for the 3D sizing of meniscal allografts or meniscal implants.

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Acknowledgements

I want to thank Mr. Charles Jauniau and his team for their availability and help in acquiring MRI data.

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Authors and Affiliations

  1. Department of Orthopaedics and Traumatology, Centre Hospitalier Universitaire d’Ambroise Paré, Hainaut, Belgium

    Valcarenghi Jérôme & Collard Xavier

  2. Department of Orthopaedics and Traumatology, Centre Hospitalier EpiCURA, Hainaut, Belgium

    Hernigou Jacques & Chahidi Esfandiar

  3. Department of Radiology, Centre Hospitalier Universitaire de Tivoli, Hainaut, Belgium

    Francotte Dorothée

  4. Department of Orthopaedics and Traumatology, Centre Hospitalier Universitaire de Tivoli, Hainaut, Belgium

    Jennart Harold

  5. Department of Orthopaedics and Traumatology, Cliniques Universitaires de Bruxelles - Hôpital Erasme, Hainaut, Belgium

    Verdonk René

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  1. Valcarenghi Jérôme
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Contributions

J.V. has been involved in the conception, study design, acquisition/interpretation of data, and drafting of the manuscript.

J.V., H.J., C.E., C.X., D.F., J.H., and R.V. have been involved in revising the manuscript critically.

D.F. has been involved in the radiological data interpretation

Each author has given final approval of the version to be published and agrees to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

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Correspondence to Valcarenghi Jérôme.

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Jérôme, V., Jacques, H., Esfandiar, C. et al. Could a three-dimensional contralateral meniscus segmentation for allograft or scaffold sizing be possible? A prospective study. International Orthopaedics (SICOT) 47, 2457–2465 (2023). https://doi.org/10.1007/s00264-023-05923-6

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