Aiken AM, Allegranzi B, Scott JA, Mehtar S, Pittet D, Grundmann H (2014) Antibiotic resistance needs global solutions. Lancet Infect Dis 14:550–551
Article
PubMed
Google Scholar
Alberti F, Rodriguez Venegas E, Hayes PM, Willis CL, Bailey AM, Foster, GD (2016) Elucidation of the biosynthetic pathway for the diterpene antibiotic pleuromutilin. Manuscript under review
Anke T, Oberwinkler F, Steglich W, Schramm G (1977) The strobilurins—new antifungal antibiotics from the basidiomycete Strobilurus tenacellus. J Antibiot 30:806–810
CAS
Article
PubMed
Google Scholar
Bailey AM, Alberti F, Kilaru S, Collins CM, de Mattos-Shipley K, Hartley AJ, Hayes PM, Griffin A, Lazarus CM, Cox RJ, Willis CL, O’Dwyer K, Spence D, Foster GD (2016) Identification and manipulation of the pleuromutilin gene cluster from Clitopilus passeckerianus for increased rapid antibiotic production. Scientific Reports 6:25202
CAS
Article
PubMed
PubMed Central
Google Scholar
Bailey AM, Cox RJ, Harley K, Lazarus CM, Simpson TJ, Skellam E (2007) Characterisation of 3-methylorcinaldehyde synthase (MOS) in Acremonium strictum: first observation of a reductive release mechanism during polyketide biosynthesis. Chem Commun 39:4053–4055
Article
Google Scholar
Barbesgaard P, Heldt-Hansen HP, Diderichsen B (1992) On the safety of Aspergillus oryzae: a review. Appl Microbiol Biotechnol 36:569–572
CAS
Article
PubMed
Google Scholar
Bartlett DW, Clough JM, Godwin JR, Hall AA, Hamer M, Parr-Dobrzanski B (2002) The strobilurin fungicides. Pest Manag Sci 58:649–662
CAS
Article
PubMed
Google Scholar
Bedford DJ, Schweizer E, Hopwood DA, Khosla C (1995) Expression of a fungal polyketide synthase in the bacterium Streptomyces coelicolor A3(2). J Bacteriol 177:4544–4548
CAS
Article
PubMed
PubMed Central
Google Scholar
Brakhage AA, Schroeckh V (2011) Fungal secondary metabolites—strategies to activate silent gene clusters. Fungal Genet Bio 48:15–22
CAS
Article
Google Scholar
Cohen JA, Barkhof F, Comi G, Hartung H-P, Khatri BO, Montalban X, Pelletier J, Capra R, Gallo P, Izquierdo G, Tiel-Wilck K, de Vera A, Jin J, Stites T, Wu S, Aradhye S, Kappos L (2010) Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N Engl J Med 362(5):402–415
CAS
Article
PubMed
Google Scholar
Cochrane RVK, Sanichar R, Lambkin GR, Reiz B, Xu W, Tang Y, Vederas JC (2016) Production of new cladosporin analogues by reconstitution of the polyketide synthases responsible for the biosynthesis of this antimalarial agent. Angew Chem Int Ed 55:664–668
CAS
Article
Google Scholar
Davison J, al Fahad A, Cai M, Song Z, Yehia SY, Lazarus CM, Bailey AM, Simpson TJ, Cox RJ (2012) Genetic, molecular, and biochemical basis of fungal tropolone biosynthesis. Proc Natl Acad Sci U S A 109:7642–7647
CAS
Article
PubMed
PubMed Central
Google Scholar
Fazakerley NJ, Helm MD, Procter DJ (2013) Total synthesis of (+)-pleuromutilin. Chem Eur J 19:6718–6723
CAS
Article
PubMed
Google Scholar
Fisch KM, Bakeer W, Yakasai AA, Song Z, Pedrick J, Wasil Z, Bailey AM, Lazarus STJ, Cox RJ (2011) Rational domain swaps decipher programming in fungal highly reducing polyketide synthases and resurrect an extinct metabolite. J Am Chem Soc 133:16635–16641
CAS
Article
PubMed
Google Scholar
Fujii R, Minami A, Tsukagoshi T, Sato N, Sahara T, Ohgiya S, Gomi K, Oikawa H (2011) Total biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase α: heterologous expression of four biosynthetic genes in Aspergillus oryzae. Biosci Biotechnol Biochem 75:1813–1817
CAS
Article
PubMed
Google Scholar
Hamad B (2010) The antibiotics market. Nat Rev Drug Discov 9:675–676
CAS
Article
PubMed
Google Scholar
Hartley AJ, de Mattos-Shipley K, Collins CM, Kilaru S, Foster GD, Bailey AM (2009) Investigating pleuromutilin-producing Clitopilus species and related basidiomycetes. FEMS Microbiol Lett 297:24–30
CAS
Article
PubMed
Google Scholar
Heneghan MN, Yakasai AA, Halo LM, Song Z, Bailey AM, Simpson TJ, Cox RJ, Lazarus CM (2010) First heterologous reconstruction of a complete functional fungal biosynthetic multigene cluster. Chembiochem 11:1508–1512
CAS
Article
PubMed
Google Scholar
Hesseltine CW, Shotwell OL, Ellis JJ, Stubblefield RD (1966) Aflatoxin formation by Aspergillus flavus. Bacteriol Rev 30:795–805
CAS
PubMed
PubMed Central
Google Scholar
Hoffmeister D, Keller NP (2007) Natural products of filamentous fungi: enzymes, genes, and their regulation. Nat Prod Rep 24:393–416
CAS
Article
PubMed
Google Scholar
Ishiuchi K, Nakazawa T, Ookuma T, Sugimoto S, Sato M, Tsunematsu Y, Ishikawa N, Noguchi N, Hotta K, Moriya H, Watanabe K (2012) Establishing a new methodology for genome mining and biosynthesis of polyketides and peptides through yeast molecular genetics. Chembiochem 13:846–854
CAS
Article
PubMed
Google Scholar
Istvan ES, Deisenhofer J (2001) Structural mechanism for statin inhibition of HMG-CoA reductase. Science 292:1160–1164
CAS
Article
PubMed
Google Scholar
Jin FJ, Maruyama J, Juvvadi PR, Arioka M, Kitamoto K (2004a) Adenine auxotrophic mutants of Aspergillus oryzae: development of a novel transformation system with triple auxotrophic hosts. Biosci Biotechnol Biochem 68:656–662
CAS
Article
PubMed
Google Scholar
Jin FJ, Maruyama J, Juvvadi PR, Arioka M, Kitamoto K (2004b) Development of a novel quadruple auxotrophic host transformation system by argB gene disruption using adeA gene and exploiting adenine auxotrophy in Aspergillus oryzae. FEMS Microbiol Lett 239:79–85
CAS
Article
PubMed
Google Scholar
Kealey JT, Liu L, Santi DV, Betlach MC, Barr PJ (1998) Production of a polyketide natural product in nonpolyketide producing prokaryotic and eukaryotic hosts. Proc Natl Acad Sci U S A 95:505–509
CAS
Article
PubMed
PubMed Central
Google Scholar
Keller NP, Hohn TM (1997) Metabolic pathway gene clusters in filamentous fungi. Fungal Genet Bio 21:17–29
CAS
Article
Google Scholar
Kilaru S, Collins CM, Hartley AJ, Bailey AM, Foster GD (2009) Establishing molecular tools for genetic manipulation of the pleuromutilin-producing fungus Clitopilus passeckerianus. Appl Environ Microb 75:7196–7204
CAS
Article
Google Scholar
Kuiper-Goodman T, Scott PM (1989) Risk assessment of the mycotoxin ochratoxin A. Biomed Environ Sci 2:179–248
CAS
PubMed
Google Scholar
Lazarus CM, Williams K, Bailey AM (2014) Reconstructing fungal natural product biosynthetic pathways. Nat Prod Rep 31(10):1339–1347
CAS
Article
PubMed
Google Scholar
Ma SM, Li JW, Choi JW, Zhou H, Lee KK, Moorthie VA, Xie X, Kealey JT, Da Silva NA, Vederas JC, Tang Y (2009) Complete reconstitution of a highly reducing iterative polyketide synthase. Science 326(5952):589–592
CAS
Article
PubMed
PubMed Central
Google Scholar
Manzoni M, Rollini M (2002) Biosynthesis and biotechnological production of statins by filamentous fungi and application of these cholesterol-lowering drugs. Appl Microbiol Biotechnol 58:555–564
CAS
Article
PubMed
Google Scholar
McLean KJ, Hans M, Meijrink B, van Scheppingen WB, Vollebregt A, Tee KL, van der Laan J-M, Leys D, Munro AW, van den Berg MA (2015) Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum. Proc Natl Acad Sci U S A 112(9):2847–2852
CAS
Article
PubMed
PubMed Central
Google Scholar
Munawar A, Marshall JW, Cox RJ, Bailey AM, Lazarus CM (2013) Isolation and characterisation of a ferrirhodin synthetase gene from the sugarcane pathogen Fusarium sacchari. Chembiochem 14(3):388–394
CAS
Article
PubMed
Google Scholar
Nielsen MT, Nielsen JB, Anyaogu DC, Holm DK, Nielsen KF, Larsen TO, Mortensen UH (2013) Heterologous reconstitution of the intact geodin gene cluster in Aspergillus nidulans through a simple and versatile PCR based approach. PLoS One 8:e72871
CAS
Article
PubMed
PubMed Central
Google Scholar
Nützmann H-W, Osbourn A (2014) Gene clustering in plant specialized metabolism. Curr Opin Biotech 26:91–99
Article
PubMed
Google Scholar
Osbourn A (2010) Secondary metabolic gene clusters: evolutionary toolkits for chemical innovation. Trends Genet 26:449–457
CAS
Article
PubMed
Google Scholar
Pahirulzaman KAK, Williams K, Lazarus CM (2012) A toolkit for heterologous expression of metabolic pathways in Aspergillus oryzae. Method Enzymol 517:241–260
CAS
Article
Google Scholar
Pfeifer BA, Admiraal SJ, Gramajo H, Cane DE, Khosla C (2001) Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli. Science 291:1790–1792
CAS
Article
PubMed
Google Scholar
Pfeifer BA, Wang CCC, Walsh CT, Khosla C (2003) Biosynthesis of yersiniabactin, a complex polyketide-nonribosomal peptide, using Escherichia coli as a heterologous host. Appl Environ Microb 69:6698–6702
CAS
Article
Google Scholar
Ro DK, Paradise EM, Ouellet M, Fisher KJ, Newman KL, Ndungu JM, Ho KA, Eachus RA, Ham TS, Kirby J, Chang MC, Withers ST, Shiba Y, Sarpong R, Keasling JD (2006) Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature 440:940–943
CAS
Article
PubMed
Google Scholar
Saikia S, Parker EJ, Koulman A, Scott B (2006) Four gene products are required for the fungal synthesis of the indole-diterpene, paspaline. FEBS Lett 580:1625–1630
CAS
Article
PubMed
Google Scholar
Saikia S, Parker EJ, Koulman A, Scott B (2007) Defining paxilline biosynthesis in Penicillium paxilli: functional characterization of two cytochrome P450 monooxygenases. J Biol Chem 282:16829–16837
CAS
Article
PubMed
Google Scholar
Sakai K, Kinoshita H, Shimizu T, Nihira T (2008) Construction of a citrinin gene cluster expression system in heterologous Aspergillus oryzae. J Biosci Bioeng 106:466–472
CAS
Article
PubMed
Google Scholar
Schmidt-Dannert C (2015) NextGen microbial natural products discovery. Microb Biotechnol 8:26–28
Article
PubMed
Google Scholar
Song Z, Bakeer W, Marshall JW, Yakasai AA, Khalid RM, Collemare J, Skellam E, Tharreau D, Lebrun M-H, Lazarus CM, Bailey AM, Simpson TJ, Cox RJ (2015) Heterologous expression of the avirulence gene ACE1 from the fungal rice pathogen Magnaporthe oryzae. Chem Sci 6:4837–4845
CAS
Article
Google Scholar
Sudakin DL (2003) Trichothecenes in the environment: relevance to human health. Toxicol Lett 143:97–107
CAS
Article
PubMed
Google Scholar
Tada S, Iimura Y, Gomi K, Takahashi K, Hara S, Yoshizawa K (1989) Cloning and nucleotide sequence of the genomic Taka-amylase A gene of Aspergillus oryzae. Agric Biol Chem 53:593–599
CAS
Google Scholar
Tagami K, Liu C, Minami A, Noike M, Isaka T, Fueki S, Shichijo Y, Toshima H, Gomi K, Dairi T, Oikawa H (2013) Reconstitution of biosynthetic machinery for indole-diterpene paxilline in Aspergillus oryzae. J Am Chem Soc 135:1260–1263
CAS
Article
PubMed
Google Scholar
Tagami K, Minami A, Fujii R, Liu C, Tanaka M, Gomi K, Dairi T, Oikawa H (2014) Rapid reconstitution of biosynthetic machinery for fungal metabolites in Aspergillus oryzae: total biosynthesis of aflatrem. Chembiochem 15:2076–2080
CAS
Article
PubMed
Google Scholar
Vaquero ME, Barriuso J, Medrano FJ, Prieto A, Martínez MJ (2015) Heterologous expression of a fungal sterol esterase/lipase in different hosts: effect on solubility, glycosylation and production. J Biosci Bioeng 120:637–643
CAS
Article
PubMed
Google Scholar
Weber G, Schörgendorfer K, Schneider-Scherzer E, Leitner E (1994) The peptide synthetase catalyzing cyclosporine production in Tolypocladium niveum is encoded by a giant 45.8-kilobase open reading frame. Curr Genet 26:120–125
CAS
Article
PubMed
Google Scholar
Weld RJ, Plummer KM, Carpenter MA, Ridgway HJ (2006) Approaches to functional genomics in filamentous fungi. Cell Res 16:31–44
CAS
Article
PubMed
Google Scholar
Wiemann P, Keller N (2013) Strategies for mining fungal natural products. J Ind Microbiol Biot 41:301–313
Article
Google Scholar
Yaegashi J, Oakley B, Wang CC (2014) Recent advances in genome mining of secondary metabolite biosynthetic gene clusters and the development of heterologous expression systems in Aspergillus nidulans. J Ind Microbiol Biot 41:433–442
CAS
Article
Google Scholar
Yamada O, Rho LB, Katsuya G (1997) Transformation system for Aspergillus oryzae with double auxotrophic mutations niaD and sC. Biosci Biotechnol Biochem 61:1367–1369
CAS
Article
Google Scholar
Yu JH, Keller N (2005) Regulation of secondary metabolism in filamentous fungi. Annu Rev Phytopathol 43:437–458
CAS
Article
PubMed
Google Scholar