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Diffuse periventricular leukomalacia in preterm children: assessment of grey matter changes by MRI

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Abstract

Background

Preterm children may have cognitive deficits and behavioural disorders suggestive of grey matter (GM) injury. The prevalence is higher in preterm children with diffuse periventricular leukomalacia (dPVL).

Objective

Evaluate changes in the volume of 116 GM areas in preterm children with dPVL.

Methods and materials

Eleven preterm children with dPVL, gestational age 32.8 ± 2.6 weeks, examined at corrected age 22.0 ± 18.2 months and 33 matched preterm controls with normal brain MRI were studied. Volumes of 116 individual GM areas, and white matter/cerebrospinal fluid (WM/CSF) ratio were calculated on T1-weighted high-resolution images after segmentation.

Results

Relative to controls, children with dPVL had decreased GM volume of the hippocampus, amygdala, and frontal lobes and temporal middle gyrus (P  <  0.05); increased GM volume of the putamen, thalamus, globus pallidum, superior temporal gyrus and of the parietal and occipital lobes (P  <  0.05) and lower WM volume/higher CSF volume (P  <  0.05). WM/CSF ratios also differed (P  <  0.05).

Conclusions

Preterm children with dPVL have increased regional GM volume in some areas probably related with a process of brain plasticity-regeneration and reduced GM volume in areas associated with cognition and memory.

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Authors and Affiliations

  1. Department of Radiology, Medical School, University of Ioannina, 45110, Ioannina, Greece

    L. C. Tzarouchi, V. Xydis, A. K. Zikou, M. Papastefanaki & Maria I. Argyropoulou

  2. Neonatal Intensive Care Unit, Child Health Department, Medical School, University of Ioannina, Ioannina, Greece

    A. Drougia & S. Andronikou

  3. Department of Medical Physics, Medical School, University of Ioannina, Ioannina, Greece

    L. G. Astrakas

Authors
  1. L. C. Tzarouchi
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  2. V. Xydis
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  3. A. K. Zikou
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  4. A. Drougia
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  5. L. G. Astrakas
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  6. M. Papastefanaki
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  7. S. Andronikou
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  8. Maria I. Argyropoulou
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Correspondence to Maria I. Argyropoulou.

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Tzarouchi, L.C., Xydis, V., Zikou, A.K. et al. Diffuse periventricular leukomalacia in preterm children: assessment of grey matter changes by MRI. Pediatr Radiol 41, 1545–1551 (2011). https://doi.org/10.1007/s00247-011-2223-z

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  • DOI: https://doi.org/10.1007/s00247-011-2223-z

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