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Postnatal clinical and imaging follow-up of infants with prenatal isolated mild ventriculomegaly: a series of 101 cases

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Abstract

Background

Postnatal imaging and clinical outcome of fetuses with isolated mild ventriculomegaly (IMV) have never been systematically analysed.

Objective

To evaluate the postnatal clinical outcomes of a large cohort of fetuses with IMV and to correlate them with pre- and postnatal imaging.

Materials and methods

We report a prospective study of 101 fetuses with IMV (10–15 mm ventriculomegaly with otherwise normal US, MRI, karyotype and TORCH screening). IMV was divided into minor (10–11.9 mm) and moderate (12–15 mm) ventriculomegaly. Ventriculomegaly was considered uni- or bilateral, stable, progressive, regressive or resolved according to the prenatal US follow-up. Clinical follow-up was performed by a neuropaediatrician. Postnatal imaging included cranial US (n = 71) and MRI (n = 76).

Results

The outcome of minor and moderate IMV was excellent in 94% and 85% of infants, respectively. It was not different between uni- and bilateral IMV, and between stable, regressive and resolved IMV, and was independent of gestational age at diagnosis and gender. Fixed neurological abnormalities were observed in nine infants. Postnatal MRI showed white-matter abnormalities in 14 infants, including 6 of the 9 infants with a poor outcome.

Conclusion

The prognosis was slightly better in minor IMV than in moderate IMV. Postnatal MRI showed white-matter abnormalities in two-thirds of the infants with a poor outcome.

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Acknowledgement

We thank Vincent Delezoide for correcting the manuscript.

Author information

Authors and Affiliations

  1. Department of Paediatric Imaging, Hôpital Robert Debré, Paris, France

    Céline Falip & Guy Sebag

  2. Department of Pediatric Neurology and Metabolic Diseases, Hôpital Robert Debré, Paris, France

    Nathalie Blanc & Emmanuelle Maes

  3. AP-HP, Unit of clinical epidemiology INSERM, Hôpital Robert Debré, Paris, France

    Isabelle Zaccaria

  4. Department of Obstetrics and Gynaecology, Hôpital Robert Debré, Paris, France

    Jean François Oury

  5. Department of Radiology, Hôpital d’Enfants Armand-Trousseau, 26-28 avenue du Docteur Arnold Netter, 75571, Paris Cedex 12, France

    Catherine Garel

Authors
  1. Céline Falip
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  2. Nathalie Blanc
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  3. Emmanuelle Maes
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  4. Isabelle Zaccaria
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  5. Jean François Oury
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  6. Guy Sebag
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  7. Catherine Garel
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Corresponding author

Correspondence to Catherine Garel.

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Falip, C., Blanc, N., Maes, E. et al. Postnatal clinical and imaging follow-up of infants with prenatal isolated mild ventriculomegaly: a series of 101 cases. Pediatr Radiol 37, 981–989 (2007). https://doi.org/10.1007/s00247-007-0582-2

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  • DOI: https://doi.org/10.1007/s00247-007-0582-2

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