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Exploring the underlying correlation between microbiota, immune system, hormones, and inflammation with breast cancer and the role of probiotics, prebiotics and postbiotics

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Abstract

According to recent research, bacterial imbalance in the gut microbiota and breast tissue may be linked to breast cancer. It has been discovered that alterations in the makeup and function of different types of bacteria found in the breast and gut may contribute to growth and advancement of breast cancer in several ways. The main role of gut microbiota is to control the metabolism of steroid hormones, such as estrogen, which are important in raising the risk of breast cancer, especially in women going through menopause. On the other hand, because the microbiota can influence mucosal and systemic immune responses, they are linked to the mutual interactions between cancer cells and their local environment in the breast and the gut. In this regard, the current review thoroughly explains the mode of action of probiotics and microbiota to eradicate the malignancy. Furthermore, immunomodulation by microbiota and probiotics is described with pathways of their activity.

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Availability of data and materials

Nearly all of the data collected during this study are incorporated in this article. However, data in raw form are available from the corresponding author upon request.

References

  • Abdoli M, Fathi Rezaei P, Mansouri K (2021) Exploring the anticancer efficacy of mixture of local probiotics on MDA-MB-231 and MCF-7 breast cell lines. J Cell Mol Res 13(1):54–64

    CAS  Google Scholar 

  • Ali HR, Provenzano E, Dawson SJ, Blows FM, Liu B, Shah M, Caldas C (2014) Association between CD8+ T-cell infiltration and breast cancer survival in 12 439 patients. Ann Oncol 25(8):1536–1543

    Article  CAS  PubMed  Google Scholar 

  • Álvarez-Mercado AI, Navarro-Oliveros M, Robles-Sánchez C, Plaza-Díaz J, Sáez-Lara MJ, Muñoz-Quezada S, Abadía-Molina F (2019) Microbial population changes and their relationship with human health and disease. Microorganisms 7(3):68

    Article  PubMed  PubMed Central  Google Scholar 

  • Álvarez-Mercado AI, del Valle Cano A, Fernández MF, Fontana L (2023) Gut microbiota and breast cancer: the dual role of microbes. Cancers 15(2):443

    Article  PubMed  PubMed Central  Google Scholar 

  • Anderson WF, Rosenberg PS, Prat A, Perou CM, Sherman ME (2014) How many etiological subtypes of breast cancer: two, three, four, or more? J Natl Cancer Inst 106(8):165

    Article  Google Scholar 

  • Arthur JC, Jobin C (2013) The complex interplay between inflammation, the microbiota and colorectal cancer. Gut Microb 4(3):253–258

    Article  Google Scholar 

  • Banakar M, Haghgoo R, Mehran M, Yazdi MH, Mohamadpour H, Saadi MI, Etemad-Moghadam S (2023) Anticancer activity of postbiotic mediators derived from Lactobacillus Rhamnosus GG and Lactobacillus Reuteri on acute lymphoblastic leukemia cells. Galen Med J 12:3096–3096

    Article  Google Scholar 

  • Bard JM, Luu HT, Dravet F, Michel C, Moyon T, Pagniez A, Bobin-Dubigeon C (2015) Relationship between intestinal microbiota and clinical characteristics of patients with early stage breast cancer. FASEB J 29:914–922

    Article  Google Scholar 

  • Behl T, Kumar K, Brisc C, Rus M, Nistor-Cseppento DC, Bustea C, Bungau S (2021) Exploring the multifocal role of phytochemicals as immunomodulators. Biomed Pharmacother 133:110959

    Article  CAS  PubMed  Google Scholar 

  • Behzadi R, Hormati A, Eivaziatashbeik K, Ahmadpour S, Khodadust F, Zaboli F, Seidi K (2021) Evaluation of anti-tumor potential of Lactobacillus acidophilus ATCC4356 culture supernatants in MCF-7 breast cancer. Anti-Cancer Agents Med Chem 21(14):1861–1870

    Article  CAS  Google Scholar 

  • Bergounioux J, Elisee R, Prunier AL, Donnadieu F, Sperandio B, Sansonetti P, Arbibe L (2012) Calpain activation by the Shigella flexneri effector VirA regulates key steps in the formation and life of the bacterium’s epithelial niche. Cell Host Microb 11(3):240–252

    Article  CAS  Google Scholar 

  • Bhatelia K, Singh K, Singh R (2014) TLRs: linking inflammation and breast cancer. Cell Signal 26(11):2350–2357

    Article  CAS  PubMed  Google Scholar 

  • Buti L, Spooner E, Van der Veen AG, Rappuoli R, Covacci A, Ploegh HL (2011) Helicobacter pylori cytotoxin-associated gene A (CagA) subverts the apoptosis-stimulating protein of p53 (ASPP2) tumor suppressor pathway of the host. Proc Natl Acad Sci 108(22):9238–9243

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chan AA, Bashir M, Rivas MN, Duvall K, Sieling PA, Pieber TR, Lee DJ (2016) Characterization of the microbiome of nipple aspirate fluid of breast cancer survivors. Sci Rep 6(1):1–11

    Article  Google Scholar 

  • Chiba A, Bawaneh A, Velazquez C, Clear KY, Wilson AS, Howard-McNatt M, Cook KL (2020) Neoadjuvant chemotherapy shifts breast tumor microbiota populations to regulate drug responsiveness and the development of metastasis. Mol Cancer Res 18(1):130–139

    Article  CAS  PubMed  Google Scholar 

  • Chondrou P, Karapetsas A, Kiousi DE, Vasileiadis S, Ypsilantis P, Botaitis S, Galanis A (2020) Assessment of the immunomodulatory properties of the probiotic strain Lactobacillus paracasei K5 in vitro and in vivo. Microorganisms 8(5):709

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chuah LO, Foo HL, Loh TC, Mohammed Alitheen NB, Yeap SK, Abdul Mutalib NE, Yusoff K (2019) Postbiotic metabolites produced by Lactobacillus plantarum strains exert selective cytotoxicity effects on cancer cells. BMC Complement Altern Med 19:1–12

    Article  CAS  Google Scholar 

  • Conti L, Lanzardo S, Arigoni M, Antonazzo R, Radaelli E, Cantarella D, Cavallo F (2013) The noninflammatory role of high mobility group box 1/toll-like receptor 2 axis in the self-renewal of mammary cancer stem cells. FASEB J 27(12):4731–4744

    Article  CAS  PubMed  Google Scholar 

  • Davani-Davari D, Negahdaripour M, Karimzadeh I, Seifan M, Mohkam M, Masoumi SJ, Ghasemi Y (2019) Prebiotics: definition, types, sources, mechanisms, and clinical applications. Foods 8(3):92

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • DeNardo DG, Coussens LM (2007) Inflammation and breast cancer. Balancing immune response: crosstalk between adaptive and innate immune cells during breast cancer progression. Breast Cancer Res 9(4):1–10

    Article  Google Scholar 

  • Di Lorenzo A, Bolli E, Ruiu R, Ferrauto G, Di Gregorio E, Avalle L, Conti L (2022) Toll-like receptor 2 promotes breast cancer progression and resistance to chemotherapy. Oncoimmunology 11(1):2086752

    Article  PubMed  PubMed Central  Google Scholar 

  • Donnet-Hughes A, Perez PF, Doré J, Leclerc M, Levenez F, Benyacoub J, Schiffrin EJ (2010) Potential role of the intestinal microbiota of the mother in neonatal immune education. Proc Nutr Soc 69(3):407–415

    Article  PubMed  Google Scholar 

  • Fernández MF, Reina-Pérez I, Astorga JM, Rodríguez-Carrillo A, Plaza-Díaz J, Fontana L (2018) Breast cancer and its relationship with the microbiota. Int J Environ Res Public Health 15(8):1747

    Article  PubMed  PubMed Central  Google Scholar 

  • Fink BN, Steck SE, Wolff MS, Britton JA, Kabat GC, Gaudet MM, Gammon MD (2007) Dietary flavonoid intake and breast cancer survival among women on long Island. Cancer Epidemiol Biomarkers Prev 16(11):2285–2292

    Article  CAS  PubMed  Google Scholar 

  • Fooladi AAI, Yazdi MH, Pourmand MR, Mirshafiey A, Hassan ZM, Azizi T, Dallal MMS (2015) Th1 cytokine production induced by Lactobacillus acidophilus in BALB/c mice bearing transplanted breast tumor. Jundishapur J Microbiol. https://doi.org/10.5812/jjm.8(4)2015.17354

    Article  Google Scholar 

  • Frugé AD, Van der Pol W, Rogers LQ, Morrow CD, Tsuruta Y, Demark-Wahnefried W (2020) Fecal Akkermansiamuciniphila is associated with body composition and microbiota diversity in overweight and obese women with breast cancer participating in a presurgical weight loss trial. J Acad Nutr Diet 120(4):650–659

    Article  PubMed  Google Scholar 

  • Fuhrman BJ, Feigelson HS, Flores R, Gail MH, Xu X, Ravel J, Goedert JJ (2014) Associations of the fecal microbiome with urinary estrogens and estrogen metabolites in postmenopausal women. J Clin Endocrinol Metab 99(12):4632–4640

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gerits E, Defraine V, Vandamme K, De Cremer K, De Brucker K, Thevissen K, Michiels J (2017) Repurposing toremifene for treatment of oral bacterial infections. Antimicrob Agents Chemother 61(3):e01846-e1916

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Goedert JJ, Jones G, Hua X, Xu X, Yu G, Flores R, Feigelson HS (2015) Investigation of the association between the fecal microbiota and breast cancer in postmenopausal women: a population-based case-control pilot study. JNCI: J Natl Cancer Inst. https://doi.org/10.1093/jnci/djv147

    Article  PubMed  PubMed Central  Google Scholar 

  • Goedert JJ, Hua X, Bielecka A, Okayasu I, Milne GL, Jones GS, Feigelson HS (2018) Postmenopausal breast cancer and oestrogen associations with the IgA-coated and IgA-noncoated faecal microbiota. Br J Cancer 118(4):471–479

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hassan Z, Mustafa S, Rahim RA, Isa NM (2016) Anti-breast cancer effects of live, heat-killed and cytoplasmic fractions of Enterococcus faecalis and Staphylococcus hominis isolated from human breast milk. In Vitro Cell Dev Biol-Animal 52(3):337–348

    Article  Google Scholar 

  • Hibino S, Kawazoe T, Kasahara H, Itoh S, Ishimoto T, Sakata-Yanagimoto M, Taniguchi K (2021) Inflammation-induced tumorigenesis and metastasis. Int J Mol Sci 22(11):5421

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hieken TJ, Chen J, Hoskin TL, Walther-Antonio M, Johnson S, Ramaker S, Degnim AC (2016) The microbiome of aseptically collected human breast tissue in benign and malignant disease. Sci Rep 6(1):1–10

    Article  Google Scholar 

  • Hong JB, Zuo W, Wang AJ, Lu NH (2016) Helicobacter pylori infection synergistic with IL-1β gene polymorphisms potentially contributes to the carcinogenesis of gastric cancer. Int J Med Sci 13(4):298

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Horigome A, Okubo R, Hamazaki K, Kinoshita T, Katsumata N, Uezono Y, Matsuoka YJ (2019) Association between blood omega-3 polyunsaturated fatty acids and the gut microbiota among breast cancer survivors. Beneficial Microb 10(7):751–758

    Article  CAS  Google Scholar 

  • Hosseini H, Abbasi A, Sabahi S, Akrami S, Yousefi-Avarvand A (2023) Assessing the potential biological activities of postbiotics derived from saccharomyces cerevisiae: an in vitro study. Probiotics Antimicrob Proteins. https://doi.org/10.1007/s12602-023-10117-y

    Article  PubMed  Google Scholar 

  • Howes BH, Watson Di, Xu C, Fosh B, Canepa M, Dean NR (2016) Quality of life following total mastectomy with and without reconstruction versus breast-conserving surgery for breast cancer: a case controlled cohort study. J PlastReconstrAesthet Surg 69(9):1184–119198

    Google Scholar 

  • Jafari B, Khavari Nejad RA, Vaziri F, Siadat SD (2019) Evaluation of the effects of extracellular vesicles derived from Faecalibacterium prausnitzii on lung cancer cell line. Biologia 74:889–898

    Article  Google Scholar 

  • Jafari-Nasab T, Khaleghi M, Farsinejad A, Khorrami S (2021) Probiotic potential and anticancer properties of Pediococcus sp. isolated from traditional dairy products. Biotechnol Rep 29:00593

    Google Scholar 

  • Jeffery IB, O’Toole PW (2013) Diet-microbiota interactions and their implications for healthy living. Nutrients 5(1):234–252

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jia D, Yang W, Li L, Liu H, Tan Y, Ooi S (2015) b-Catenin and NF-kB coactivation triggered by TLR3 stimulation facilitates stem cell-like phenotypes in breast cancer. Cell Death Differ 22:298–310

    Article  CAS  PubMed  Google Scholar 

  • Jiang Q, Charoensiddhi S, Xue X, Sun B, Liu Y, El-Seedi HR, Wang K (2023) A review on the gastrointestinal protective effects of tropical fruit polyphenols. Crit Rev Food Sci Nutr 63(24):7197–7223

    Article  CAS  PubMed  Google Scholar 

  • Kassayova M, Bobrov N, Strojný L, Orendáš P, Demečková V, Jendželovský R, Fedoročko P (2016) Anticancer and immunomodulatory effects of Lactobacillus plantarum LS/07, inulin and melatonin in NMU-induced rat model of breast cancer. Anticancer Res 36(6):2719–2728

    CAS  PubMed  Google Scholar 

  • Klement RJ, Pazienza V (2019) Impact of different types of diet on gut microbiota profiles and cancer prevention and treatment. Medicina 55(4):84

    Article  PubMed  PubMed Central  Google Scholar 

  • Komohara Y, Kurotaki D, Tsukamoto H, Miyasato Y, Yano H, Pan C, Fujiwara Y (2023) Involvement of protumor macrophages in breast cancer progression and characterization of macrophage phenotypes. Cancer Sci 114(6):2220

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Konishi H, Fujiya M, Tanaka H, Ueno N, Moriichi K, Sasajima J, Kohgo Y (2016) Probiotic-derived ferrichrome inhibits colon cancer progression via JNK-mediated apoptosis. Nat Commun 7(1):12365

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Laborda-Illanes A, Sanchez-Alcoholado L, Dominguez-Recio ME, Jimenez-Rodriguez B, Lavado R, Comino-Méndez I, Queipo-Ortuño MI (2020) Breast and gut microbiota action mechanisms in breast cancer pathogenesis and treatment. Cancers 12(9):2465

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lacey JV, Kreimer AR, Buys SS, Marcus PM, Chang SC, Leitzmann MF, Hartge P (2009) Breast cancer epidemiology according to recognized breast cancer risk factors in the prostate, lung, colorectal and ovarian (PLCO) cancer screening trial cohort. BMC Cancer 9(1):1–8

    Article  Google Scholar 

  • Lakritz JR, Poutahidis T, Levkovich T, Varian BJ, Ibrahim YM, Chatzigiagkos A, Erdman SE (2014) Beneficial bacteria stimulate host immune cells to counteract dietary and genetic predisposition to mammary cancer in mice. Int J Cancer 135(3):529–540

    Article  CAS  PubMed  Google Scholar 

  • Li X, Zhang S, Guo G, Han J, Yu J (2022) Gut microbiome in modulating immune checkpoint inhibitors. EBioMedicine. https://doi.org/10.1016/j.ebiom.2022.104163

    Article  PubMed  PubMed Central  Google Scholar 

  • Liu S, Foulkes WD, Leung S, Gao D, Lau S, Kos Z, Nielsen TO (2014) Prognostic significance of FOXP3+ tumor-infiltrating lymphocytes in breast cancer depends on estrogen receptor and human epidermal growth factor receptor-2 expression status and concurrent cytotoxic T-cell infiltration. Breast Cancer Res 16(5):1–12

    Article  Google Scholar 

  • Luang-In V, Saengha W, Buranrat B, Nudmamud-Thanoi S, Narbad A, Pumriw S, Samappito W (2020) Cytotoxicity of lactobacillus plantarum KK518 isolated from Pak-Sian Dong (Thai Fermented Gynandropsis pentaphylla DC.) against HepG2, MCF-7 and HeLa cancer cells. Pharmacogn J. https://doi.org/10.5530/pj.2020.12.148

    Article  Google Scholar 

  • Luu TH, Michel C, Bard JM, Dravet F, Nazih H, Bobin-Dubigeon C (2017) Intestinal proportion of Blautia sp. is associated with clinical stage and histoprognostic grade in patients with early-stage breast cancer. Nutr Cancer 69(2):267–275

    Article  CAS  PubMed  Google Scholar 

  • Mantovani A, Allavena P, Sica A, Balkwill F (2008) Cancer-related inflammation. Nature 454(7203):436–444

    Article  CAS  PubMed  Google Scholar 

  • Miller KD, Siegel RL, Lin CC, Mariotto AB, Kramer JL, Rowland JH, Jemal A (2016) Cancer treatment and survivorship statistics, 2016. CA: A Cancer J Clin 66(4):271–289

    Google Scholar 

  • Motta G, Cea M, Carbone F, Augusti V, Moran E, Patrone F, Nencioni A (2011) Current standards and future strategies in immunochemotherapy of non-Hodgkin’s lymphoma. J BU ON 16(1):9–15

    CAS  Google Scholar 

  • Muresan XM, Bouchal J, Culig Z, Souček K (2020) Toll-like receptor 3 in solid cancer and therapy resistance. Cancers 12(11):3227

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nami Y, Abdullah N, Haghshenas B, Radiah D, Rosli R, Khosroushahi AY (2014) Assessment of probiotic potential and anticancer activity of newly isolated vaginal bacterium Lactobacillus plantarum 5BL. Microbiol Immunol 58(9):492–502

    Article  CAS  PubMed  Google Scholar 

  • Naveed S, Ahmed SM, Ali Z, Awan R, Zakir H, Ghazi L, Nageen A (2016) H. Pylori infection: frequency in cirrhotic patients with upper gi bleed. Prof Med J 23(03):307–311

    Google Scholar 

  • Nowak A, Zakłos-Szyda M, Rosicka-Kaczmarek J, Motyl I (2022) Anticancer potential of post-fermentation media and cell extracts of probiotic strains: an in vitro study. Cancers 14(7):1853

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pakbin B, Dibazar SP, Allahyari S, Javadi M, Amani Z, Farasat A, Darzi S (2022) Anticancer properties of probiotic Saccharomyces boulardii supernatant on human breast cancer cells. Probiotics Antimicrob Proteins 14(6):1130–1138

    Article  CAS  PubMed  Google Scholar 

  • Paul B, Barnes S, Demark-Wahnefried W, Morrow C, Salvador C, Skibola C, Tollefsbol TO (2015) Influences of diet and the gut microbiome on epigenetic modulation in cancer and other diseases. Clin Epigenetics 7(1):1–11

    Article  CAS  Google Scholar 

  • Pellegrini M, Ippolito M, Monge T, Violi R, Cappello P, Ferrocino I, Finocchiaro C (2020) Gut microbiota composition after diet and probiotics in overweight breast cancer survivors: a randomized open-label pilot intervention trial. Nutrition 74:110749

    Article  CAS  PubMed  Google Scholar 

  • Pereira LMS, Gomes STM, Ishak R, Vallinoto ACR (2017) Regulatory T cell and forkhead box protein 3 as modulators of immune homeostasis. Front Immunol 8:605

    Article  PubMed  PubMed Central  Google Scholar 

  • Plottel CS, Blaser MJ (2011) Microbiome and malignancy. Cell Host Microbe 10(4):324–335

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pourbaferani M, Modiri S, Norouzy A, Maleki H, Heidari M, Alidoust L, Noghabi KA (2021) A newly characterized potentially probiotic strain, Lactobacillus brevis MK05, and the toxicity effects of its secretory proteins against MCF-7 breast cancer cells. Probiotics Antimicrob Proteins 13:982–992

    Article  CAS  PubMed  Google Scholar 

  • Pourmollaei S, Barzegari A, Farshbaf-Khalili A, Nouri M, Fattahi A, Shahnazi M, Dittrich R (2020) Anticancer effect of bacteria on cervical cancer: molecular aspects and therapeutic implications. Life Sci 246:117413

    Article  CAS  PubMed  Google Scholar 

  • Qi X, Yun C, Pang Y, Qiao J (2021) The impact of the gut microbiota on the reproductive and metabolic endocrine system. Gut Microbes 13(1):1894070

    Article  PubMed  PubMed Central  Google Scholar 

  • Rajoka MSR, Zhao H, Lu Y, Lian Z, Li N, Hussain N, Shi J (2018) Anticancer potential against cervix cancer (HeLa) cell line of probiotic Lactobacillus casei and Lactobacillus paracasei strains isolated from human breast milk. Food Funct 9(5):2705–2715

    Article  Google Scholar 

  • Ranjbar R, Behzadi P, Farshad S (2017) Advances in diagnosis and treatment of Helicobacter pylori infection. Acta Microbiol Immunol Hung 64(3):273–292

    Article  CAS  PubMed  Google Scholar 

  • Riaz Rajoka MS, Zhao H, Mehwish HM, Li N, Lu Y, Lian Z (2019) Anti-tumor potential of cell free culture supernatant of Lactobacillus rhamnosus strains isolated from human breast milk. Food Res Int 123:286–297

    Article  CAS  PubMed  Google Scholar 

  • Routy B, Gopalakrishnan V, Daillère R, Zitvogel L, Wargo JA, Kroemer G (2018) The gut microbiota influences anticancer immunosurveillance and general health. Nat Rev Clin Oncol 15(6):382–396

    Article  CAS  PubMed  Google Scholar 

  • Ruo SW, Alkayyali T, Win M, Tara A, Joseph C, Kannan A, Poudel S (2021) Role of gut microbiota dysbiosis in breast cancer and novel approaches in prevention, diagnosis, and treatment. Cureus. https://doi.org/10.7759/cureus.17472

    Article  PubMed  PubMed Central  Google Scholar 

  • Rutkowski MR, Svoronos N, Perales-Puchalt A, Conejo-Garcia JR (2015) The tumor macroenvironment: cancer-promoting networks beyond tumor beds. Adv Cancer Res 128:235–262

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Saadat YR, Khosroushahi AY, Gargari BP (2019) A comprehensive review of anticancer, immunomodulatory and health beneficial effects of the lactic acid bacteria exopolysaccharides. Carbohydr Polym 217:79–89

    Article  Google Scholar 

  • Salaun B, Zitvogel L, Asselin-Paturel C, Morel Y, Chemin K, Dubois C, Andre F (2011) TLR3 as a biomarker for the therapeutic efficacy of double-stranded RNA in breast cancer. Cancer Res 71(5):1607–1614

    Article  CAS  PubMed  Google Scholar 

  • Salimi V, Shahsavari Z, Safizadeh B, Hosseini A, Khademian N, Tavakoli-Yaraki M (2017) Sodium butyrate promotes apoptosis in breast cancer cells through reactive oxygen species (ROS) formation and mitochondrial impairment. Lipids Health Dis 16(1):1–11

    Article  Google Scholar 

  • Savas P, Salgado R, Denkert C, Sotiriou C, Darcy PK, Smyth MJ, Loi S (2016) Clinical relevance of host immunity in breast cancer: from TILs to the clinic. Nat Rev Clin Oncol 13(4):228–241

    Article  CAS  PubMed  Google Scholar 

  • Sentürk M, Ercan F, Yalcin S (2020) The secondary metabolites produced by Lactobacillus plantarum downregulate BCL-2 and BUFFY genes on breast cancer cell line and model organism Drosophila melanogaster: molecular docking approach. Cancer Chemother Pharmacol 85(1):33–45

    Article  PubMed  Google Scholar 

  • Sharma M, Arora I, Stoll ML, Li Y, Morrow CD, Barnes S, Tollefsbol TO (2020) Nutritional combinatorial impact on the gut microbiota and plasma short-chain fatty acids levels in the prevention of mammary cancer in Her2/neu estrogen receptor-negative transgenic mice. PLoS ONE 15(12):0234893

    Article  Google Scholar 

  • Sheng J, Shi W, Guo H, Long W, Wang Y, Qi J, Liu J, Xu Y (2019) The inhibitory effect of (−)-epigallocatechin-3-gallate on breast cancer progression via reducing SCUBE2 methylation and DNMT activity. Molecules 24:2899

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shi S, Xu C, Fang X, Zhang Y, Li H, Wen W, Yang G (2020) Expression profile of toll-like receptors in human breast cancer. Mol Med Rep 21(2):786–794

    PubMed  Google Scholar 

  • Shively CA, Register TC, Appt SE, Clarkson TB, Uberseder B, Clear KY, Cook KL (2018) Consumption of Mediterranean versus Western diet leads to distinct mammary gland microbiome populations. Cell Rep 25(1):47–56

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Smith PM, Howitt MR, Panikov N, Michaud M, Gallini CA, Bohlooly-y M, Garrett WS (2013) The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science 341(6145):569–573

    Article  CAS  PubMed  Google Scholar 

  • Srikham K, Daengprok W, Niamsup P, Thirabunyanon M (2021) Characterization of Streptococcus salivarius as new probiotics derived from human breast milk and their potential on proliferative inhibition of liver and breast cancer cells and antioxidant activity. Front Microbiol 12:797445

    Article  PubMed  PubMed Central  Google Scholar 

  • Sugimoto A, Numaguchi T, Chihama R, Takenaka Y, Sato Y (2023) Identification of novel lactic acid bacteria with enhanced protective effects against influenza virus. PLoS ONE 18(8):e0273604

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Summer M, Ali S, Fiaz U, Tahir HM, Ijaz M, Mumtaz S, Fiaz H (2023) Therapeutic and immunomodulatory role of probiotics in breast cancer: a mechanistic review. Arch Microbiol 205(8):296

    Article  CAS  PubMed  Google Scholar 

  • Terpou A, Papadaki A, Lappa IK, Kachrimanidou V, Bosnea LA, Kopsahelis N (2019) Probiotics in food systems: significance and emerging strategies towards improved viability and delivery of enhanced beneficial value. Nutrients 11(7):1591

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Thompson KJ, Ingle JN, Tang X, Chia N, Jeraldo PR, Walther-Antonio MR, Kalari KR (2017) A comprehensive analysis of breast cancer microbiota and host gene expression. PLoS ONE 12(11):0188873

    Article  Google Scholar 

  • Togashi Y, Shitara K, Nishikawa H (2019) Regulatory T cells in cancer immunosuppression—implications for anticancer therapy. Nat Rev Clin Oncol 16(6):356–371

    Article  CAS  PubMed  Google Scholar 

  • Urbaniak C, Cummins J, Brackstone M, Macklaim JM, Gloor GB, Baban CK, Reid G (2014) Microbiota of human breast tissue. Appl Environ Microbiol 80(10):3007–3014

    Article  PubMed  PubMed Central  Google Scholar 

  • Urbaniak C, Gloor GB, Brackstone M, Scott L, Tangney M, Reid G (2016) The microbiota of breast tissue and its association with breast cancer. Appl Environ Microbiol 82(16):5039–5048

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Van WA, Lanting CI, Goldbohm RA, van den Brandt PA, Grooters HG, Kampman E, Elias SG (2015) The proportion of postmenopausal breast cancer cases in the Netherlands attributable to lifestyle-related risk factors. Breast Cancer Res Treat 152(1):155–162

    Article  Google Scholar 

  • Vetvicka V, Saraswat-Ohri S, Vashishta A, Descroix K, Jamois F, Yvin JC, Ferrières V (2011) New 4-deoxy-(1→ 3)-β-d-glucan-based oligosaccharides and their immunostimulating potential. Carbohydr Res 346(14):2213–2221

    Article  CAS  PubMed  Google Scholar 

  • Vivarelli S, Salemi R, Candido S, Falzone L, Santagati M, Stefani S, Libra M (2019) Gut microbiota and cancer: from pathogenesis to therapy. Cancers 11(1):38

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang H, Altemus J, Niazi F, Green H, Calhoun BC, Sturgis C, Eng C (2017) Breast tissue, oral and urinary microbiomes in breast cancer. Oncotarget 8(50):88122

    Article  PubMed  PubMed Central  Google Scholar 

  • Whang YM, Jo U, Sung JS, Ju HJ, Kim HK, Park KH, Kim YH (2013) Wnt5a is associated with cigarette smoke-related lung carcinogenesis via protein kinase C. PLoS ONE 8(1):53012

    Article  Google Scholar 

  • WHO. (2023). Breast cancer. https://www.who.int/news-room/fact-sheets/detail/breast-cancer.

  • Wieërs G, Belkhir L, Enaud R, Leclercq S, Philippart de Foy JM, Dequenne I, de Timary P, Cani PD (2020) How probiotics affect the microbiota. Front Cell Infect Microbiol 9:454

    Article  PubMed  PubMed Central  Google Scholar 

  • Wisotsky E, Hanrahan N, Lione TP, Maltser S (2017) Deconstructing postmastectomy syndrome: implications for physiatric management. Phy Med Rehabil Clin N Am 28(1):153–169

    Article  Google Scholar 

  • Wu K, Zhang H, Fu Y, Zhu Y, Kong L, Chen L, Chen X (2018) TLR4/MyD88 signaling determines the metastatic potential of breast cancer cells. Mol Med Rep 18(3):3411–3420

    CAS  PubMed  PubMed Central  Google Scholar 

  • Xie W, Wang Y, Huang Y, Yang H, Wang J, Hu Z (2009) Toll-like receptor 2 mediates invasion via activating NF-κB in MDA-MB-231 breast cancer cells. Biochem Biophys Res Commun 379(4):1027–1032

    Article  CAS  PubMed  Google Scholar 

  • Xuan C, Shamonki JM, Chung A, DiNome ML, Chung M, Sieling PA, Lee DJ (2014) Microbial dysbiosis is associated with human breast cancer. PLoS ONE 9(1):e83744

    Article  PubMed  PubMed Central  Google Scholar 

  • Yang H, Wang B, Wang T, Xu L, He C, Wen H, Zhu X (2014) Toll-like receptor 4 prompts human breast cancer cells invasiveness via lipopolysaccharide stimulation and is overexpressed in patients with lymph node metastasis. PLoS ONE 9(10):109980

    Article  Google Scholar 

  • Yazdi MH, Dallal MMS, Hassan ZM, Holakuyee M, Amiri SA, Abolhassani M, Mahdavi M (2010) Oral administration of Lactobacillus acidophilus induces IL-12 production in spleen cell culture of BALB/c mice bearing transplanted breast tumour. Br J Nutr 104(2):227–232

    Article  CAS  PubMed  Google Scholar 

  • Yazdi HR, Movafagh A, Fallah F, Alizadeh Shargh S, Mansouri N, Heidary Pour A, Hashemi M (2016) Evaluation of Methylobacterium radiotolerance and Sphyngomonasyanoikoaie in sentinel lymph nodes of breast cancer cases. Asian Pac J Cancer Prev 17(S3):279–285

    Article  PubMed  Google Scholar 

  • Zamberi NR, Abu N, Mohamed NE, Nordin N, Keong YS, Beh BK, Alitheen NB (2016) The antimetastatic and antiangiogenesis effects of kefir water on murine breast cancer cells. Integr Cancer Ther 15(4):53–66

    Article  Google Scholar 

  • Zang J, Zheng MH, Cao XL, Zhang YZ, Zhang YF, Gao XY, Liang L (2020) Adenovirus infection promotes the formation of glioma stem cells from glioblastoma cells through the TLR9/NEAT1/STAT3 pathway. Cell Commun Signal 18(1):1–14

    Article  Google Scholar 

  • Zengul AG, Demark-Wahnefried W, Barnes S, Morrow CD, Bertrand B, Berryhill TF, Frugé AD (2021) Associations between dietary fiber, the fecal microbiota and estrogen metabolism in postmenopausal women with breast cancer. Nutr Cancer 73(7):1108–1117

    Article  CAS  PubMed  Google Scholar 

  • Zhu Y, Kawaguchi K, Kiyama R (2017) Differential and directional estrogenic signaling pathways induced by enterolignans and their precursors. PLoS ONE 12(2):0171390

    Article  Google Scholar 

  • Zhu J, Liao M, Yao Z, Liang W, Li Q, Liu J, Mo Z (2018) Breast cancer in postmenopausal women is associated with an altered gut metagenome. Microbiome 6(1):1–13

    Article  Google Scholar 

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Acknowledgements

For the current study, the authors are extremely obliged to the Department of Zoology, Government College University, Lahore, Pakistan, for the provision of research facilities.

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Funding was not available for this study.

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Authors and Affiliations

  1. Medical Toxicology and Biochemistry Laboratory, Department of Zoology, Government College University, Lahore, 54000, Pakistan

    Muhammad Summer, Ayesha Sajjad, Shaukat Ali & Tauqeer Hussain

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  1. Muhammad Summer
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  2. Ayesha Sajjad
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  3. Shaukat Ali
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  4. Tauqeer Hussain
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Contributions

MS edited the manuscript and did the software work. AS did writeup. SA supervises and analyzes the data. TH did the pictorial work.

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Correspondence to Shaukat Ali.

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Communicated by Yusuf Akhter.

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Summer, M., Sajjad, A., Ali, S. et al. Exploring the underlying correlation between microbiota, immune system, hormones, and inflammation with breast cancer and the role of probiotics, prebiotics and postbiotics. Arch Microbiol 206, 145 (2024). https://doi.org/10.1007/s00203-024-03868-x

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  • DOI: https://doi.org/10.1007/s00203-024-03868-x

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