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Therapeutic and immunomodulatory role of probiotics in breast cancer: A mechanistic review

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Abstract

Breast cancer has become the most prevalent and noxious type of malignancy around the globe (Giaquinto et al., 2022). Multiple clinical strategies including chemotherapy, radiotherapy, and immunotherapy have been in practice to manage breast cancer. Besides the protective roles of conventional remedial approaches, and non-reversible and deteriorative impacts like healthy cell damage, organ failure, etc., the world scientific community is in a continuous struggle to find some alternative biocompatible and comparatively safe solutions. Among novel breast cancer management/treatment options, the role of probiotics has become immensely important. The current review encompasses the prevalence statistics of breast cancer across the globe concerning developed and undeveloped counties, intestinal microbiota linkage with breast cancer, and association of breast microbiome with breast carcinoma. Furthermore, this review also narrates the role of probiotics against breast cancer and their mode of action. In Vivo and In Vitro studies under breast cancer research regarding probiotics are mechanistically explained. The current review systematically explains the immunomodulatory role of probiotics to prevent breast cancer. Last, but not the least, current review concludes the use of probiotics in the treatment of breast cancer through various mechanisms and future recommendations for molecular basis studies.

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The data sets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Funding

The current study was not funded by anybody/organization.

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Authors and Affiliations

  1. Department of Zoology, Government College University Lahore, Lahore, 54000, Pakistan

    Muhammad Summer, Shaukat Ali, Umaima Fiaz, Hafiz Muhammad Tahir, Shumaila Mumtaz, Rabia Mushtaq, Rida Khan & Hafsa Shahzad

  2. Department of Veterinary Medicine, University of Veterinary and Animal Sciences Lahore, Lahore, Pakistan

    Muhammad Ijaz

  3. Department of Medicine and Surgery, Ammer-ul-din Medical College Lahore, Lahore, Pakistan

    Hashim Fiaz

Authors
  1. Muhammad Summer
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  2. Shaukat Ali
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  3. Umaima Fiaz
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  4. Hafiz Muhammad Tahir
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  9. Hafsa Shahzad
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  10. Hashim Fiaz
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Contributions

MS wrote the manuscript. SA planned, supervised, edited the manuscript and analyzed the data. UF wrote the manuscript and pictorial work. MT analyzed the data. MI provided the data for mechanistic study and analyzed the data. SM assisted in writeup. HS assisted in writeup. RM edited the manuscript. RK edited the manuscript. HF assisted in writeup and reference management.

Corresponding author

Correspondence to Shaukat Ali.

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As no animal is being used/sacrificed in present study, ethical approval was not applicable.

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Communicated by Ran Wang.

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Summer, M., Ali, S., Fiaz, U. et al. Therapeutic and immunomodulatory role of probiotics in breast cancer: A mechanistic review. Arch Microbiol 205, 296 (2023). https://doi.org/10.1007/s00203-023-03632-7

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  • DOI: https://doi.org/10.1007/s00203-023-03632-7

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