Abstract
Piretanide, 4-phenoxy-3-(pyrrolidinyl)-5-sulphamoyl benzoic acid, apart from being an efficient diuretic, enhances endogenous plasma fibrinolytic activity after a single dose of 6 mg administered by oral route. After ingestion of the drug, acceleration of fibrinolytic acitivity became manifest within 1 h, reached its peak in 3 h and was associated with a fall in fibrinogen and diminished urokinase excretion. Piretanide did not cause lysis of fibrinin vitro. Primary platelet aggregation, induced by adenosine-diphosphate, was inhibited by piretanide. Inin vitro experiments piretanide led to effective inhibition of adenosine-diphosphate-induced platelet aggregation with complete inhibition at 5 mM concentration. Piretanide led to a highly significant decrease of platelet factor-4 release.
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Abbreviations
- PF-4:
-
Platelet factor-4
- ADP:
-
adenosine-diphosphate
- PRP:
-
platelet rich plasma
- PAT:
-
platelet aggregation times
- f.c.:
-
final concentration
- PGG2 :
-
prostaglandin endoperoxides
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Chohan, I.S. Effects of piretanide on plasma fibrinolytic activity, platelet aggregation and platelet factor-4 release in man. J Biosci 10, 243–249 (1986). https://doi.org/10.1007/BF02703482
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DOI: https://doi.org/10.1007/BF02703482