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Effect of diabetes therapy on the myocardium in experimental diabetes

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Summary

The effects of chronic antidiabetic treatment were examined in a clinically manifest, but nonketotic diabetic animal model in which increased stabilization of steric structure in the cardiac connective tissue and left ventricular diastolic stiffness have been demonstrated. These changes accounted for decreased left ventricular performance during left ventricular afterload. Each of 8 diabetic dogs was given daily 8–16 IU of insulin, 250–750 mg carbutamide or 2–10 mg glibenclamide, respectively; doses were always adjusted to the actual metabolic requirements and findings were compared to those of 11 untreated diabetic and 6 healthy dogs. After three months, the hemodynamic and metabolic studies showed that the metabolically controlled diabetic dogs had less marked alterations in the connective cardiac tissue, left ventricular diastolic stiffness and performance. Apart from a considerable rise of arterial blood pressure during carbutamide treatment, no other difference was found in the cardiac actions of the three hypoglycemic agents tested.

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References

  1. Ahmed S. S., Jaferi G. A., Narang R. M., Regan T. J.: Preclinical abnormality of left ventricular function in diabetes mellitus — Amer. Heart J.89, 153, 1975.

    Article  PubMed  CAS  Google Scholar 

  2. Bihari-Varga M.: Thermoanalytical characterization of the stability of crosslinked proteins — Acta biochim. biophys. Acad. Sci. hung.6, 265, 1971.

    PubMed  CAS  Google Scholar 

  3. Bihari-Varga M.: Thermoanalytical assay of glucosaminoglycans — Acta biochim. biophys. Acad. Sci. hung.6, 271, 1971.

    PubMed  CAS  Google Scholar 

  4. Blumenthal H. T., Alex M., Goldenberg S.: A study of lesions of the intramural coronary artery branches in diabetes mellitus — A.M.A. Arch. Path.70, 13, 1960.

    Google Scholar 

  5. Caufield J. B.: Dermal elastic tissue of diabetics — Beitr. Pathol.145, 286, 1972.

    Google Scholar 

  6. Coulomba J. J., Favreau L.: A new simple semimicromethod for colorimetric determination of urea — Clin. Chem.9, 102, 1963.

    Google Scholar 

  7. Diamond G., Forrester J. S.: Effect of coronary artery disease and acute myocardial infarction on left ventricular compliance in man — Circulation45, 11, 1972.

    PubMed  CAS  Google Scholar 

  8. Hamby R. I., Zoneraich S., Sherman L.: Diabetic cardiomyopathy — J. Amer. med. Ass.229, 1749, 1974.

    Article  CAS  Google Scholar 

  9. Howorth P. J. N., Gibbard S., Marks V.: Evaluation of a colorimetric method (Duncombe) of determination of plasma non-esterified fatty acids — Clin. chim. Acta14, 69, 1976.

    Article  Google Scholar 

  10. Huston J. H., Abboud F. M.: Measurement of arterial aging in relation to diabetes mellitus — Circulation25, 938, 1962.

    PubMed  CAS  Google Scholar 

  11. Hyvarinen A., Nikkilä E. A.: Specific determination of blood glucose with o-toluidine — Clin. chim. Acta7, 140, 1962.

    Article  PubMed  CAS  Google Scholar 

  12. James T. N.: Pathology of small coronary arteries — Amer. J. Cardiol.20, 691, 1967.

    Article  Google Scholar 

  13. Juhász-Nagy S., Dubecz E., Pogátsa G., Gábor Gy.: Elevated left ventricular stiffness by noradrenaline in myocardial ischaemia — Experientia (Basel)31, 945, 1975.

    Google Scholar 

  14. Kakhonovsky I. M., Shiyan I. V., Grishina I. M.: Phazowaia structura serdetschnowo socrashtschenia u bolnich sacharnim diabetom — Ter. Arkh.43, 51, 1971.

    Google Scholar 

  15. Karlefors T.: Haemodynamic studies in male diabetics — Acta med. scand.180 (Suppl. 449), 45, 1966).

    Google Scholar 

  16. Kessler G., Lederer H.: Fluorometric measurement of triglycerides — In:Kessler G., Lederer H. (Eds): Automation in analytical chemistry, Vol. 1, Technicon Symposia. Mediad Inc., White Plains, 1967; p. 341.

    Google Scholar 

  17. Kübler W., Zebe H.: Die diabetische Kardiomyopathie — Internist (Berl.)16, 520, 1975.

    Google Scholar 

  18. Ledet T.: Diabetic cardiopathy. Quantitative histological studies of the heart from young juvenile diabetics — Acta path. microbiol. scand.84, 421, 1976.

    CAS  Google Scholar 

  19. Neuweiler W.: Quantitative Bestimmung der Aceton-Körper in Blut mittels des Stufenphotometers — Klin. Wschr.12, 869, 1933.

    Article  CAS  Google Scholar 

  20. Pillsbury H. C., Hung W., Kyle M. C., Freis E. D.: Arterial pulse waves and systolic time intervals in diabetic children — Amer. Heart J.87, 783, 1974.

    Article  PubMed  Google Scholar 

  21. Pogátsa G., Dubecz E.: The direct effect of hypoglycaemic sulphonylureas on myocardial contractile force and arterial blood pressure — Diabetologia13, 515, 1977.

    Article  PubMed  Google Scholar 

  22. Pogátsa G., Dubecz E., Gábor Gy.: The role of myocardial edema in the left ventricular diastolic stiffness — Basic Res. Cardiol.71, 263, 1976.

    Article  PubMed  Google Scholar 

  23. Pogátsa G., Dubecz E., Juhász-Nagy S., Kolonics I., Gábor Gy.: The role of myocardial oedema in the reduction of left ventricular compliance — Acta med. Acad. Sci. hung.34, 71, 1977.

    Google Scholar 

  24. Regan T. J.: Left ventricular function in diabetes mellitus. Reply — Amer. Heart J.90, 538, 1975.

    Article  Google Scholar 

  25. Regan T. J., Ettinger P. O., Khan M. I., Jesrani M. U., Lyons M. M., Oldewurtel H. A., Weber M.: Altered myocardial function and metabolism in chronic diabetes mellitus without ischemia in dogs — Circulat. Res.35, 222, 1974.

    CAS  Google Scholar 

  26. Regan T. J., Jaferi G. A., Ahmed S. S., Oldewurtel H. A., Lyons M. M.: Abnormalities of left ventricular function and morphology in diabetes mellitus without evident ischemia — Clin. Res.22, 555A, 1974.

  27. Regan T. J., Khan M. I., Jesrani M. U., Oldewurtel H. A., Ettinger P. O.: Alterations of myocardial function and metabolism in chronic diabetes mellitus — In:Dhalla N. S. (Ed.): Myocardial metabolism. Urban & Schwarzenberg, München, 1974; p. 169.

    Google Scholar 

  28. Rerup C. C.: Drugs producing diabetes through damage of the insulin secreting cells — Pharmacol. Rev.22, 485, 1970.

    PubMed  CAS  Google Scholar 

  29. Rubler S., Dlugash J., Yuceglu Y. Z., Kumral T., Branwood A. W., Crishman A.: New type of cardiomyopathy associated with diabetic glomerulosclerosis — Amer. J. Cardiol.30, 595, 1972.

    Article  PubMed  CAS  Google Scholar 

  30. Salisbury P. F., Cross C. E., Katsuhara K., Rieben P. A.: Factors which initiate or influence edema in the isolated dog’s heart — Circulation9, 601, 1961.

    CAS  Google Scholar 

  31. Schuyler M. R., Niewoehner D. E., Inkley S. R., Kohn R.: Abnormal lung elasticity in juvenile diabetes mellitus — Amer. Rev. resp. Dis.113, 37, 1976.

    PubMed  CAS  Google Scholar 

  32. Sohar E., Ravid M., Ben-Shaul Y., Reshef T., Gafni J.: Diabetic fibrillosis — Amer. J. Med.49, 64, 1970.

    Article  PubMed  CAS  Google Scholar 

  33. Utley J. R., Michalsky G. B., Bryant L. R., Mobin-Uddin K., McKean H. E.: Determinants of myocardial water content during cardiopulmonary bypass — J. thorac. cardiovasc. Surg.68, 8, 1974.

    PubMed  CAS  Google Scholar 

  34. Watson D.: A simple method for the determination of serum cholesterin — Clin. chim. Acta5, 637, 1960.

    Article  PubMed  CAS  Google Scholar 

  35. Wu C. F., Haider B., Ahmed S. S., Oldewurtel H. A., Lyons M. M., Regan T. J.: The effects of tolbutamide on the myocardium in experimental diabetes — Circulation55, 200, 1977.

    PubMed  CAS  Google Scholar 

  36. Zöllner N., Kirsch K.: Über die quantitative Bestimmung von Lipoiden (Mikromethode) mittels der vielen natürlichen Lipoiden (allen bekannten Plasmalipoiden) gemeinsamen Sulfophosphovanillin-Reaktion — Z. ges. exp. Med.135, 545, 1962.

    Article  Google Scholar 

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Authors and Affiliations

  1. Országos Kardiológiai Intézet, Kutatásai Egység és Semmelweis Orvostudományi Egyetem, II. sz. Kórbonctani Intézet, Budapest

    Gábor Pogátsa, Magdolna Bihari-Varga & Gyula Szinay

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  1. Gábor Pogátsa
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  2. Magdolna Bihari-Varga
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  3. Gyula Szinay
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Pogátsa, G., Bihari-Varga, M. & Szinay, G. Effect of diabetes therapy on the myocardium in experimental diabetes. Acta diabet. lat 16, 129–138 (1979). https://doi.org/10.1007/BF02581092

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  • DOI: https://doi.org/10.1007/BF02581092

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