The Histochemical Journal

, Volume 27, Issue 10, pp 727–737 | Cite as

Nitric oxide in physiology and pathology

  • Brendan J. R. Whittle


Nitric oxide (NO) can exert a multitude of biological actions. NO, formed froml-arginine by a calcium-dependent enzyme (NO synthase) plays a key physiological role in regulating vascular tone and integrity. NO, formed by a constitutive neuronal isoform of NO synthase, likewise plays an important neuromodulator role. By contrast, high levels of NO can be generated following induction of a calcium-independent isoform of NO synthase. This excessive production of NO can provoke hypotension such as that observed in septic shock, and can exert cytotoxic actions leading to tissue injury and inflammation. Selective inhibitors of this inducible isoform thus have therapeutic potential in a number of disease states.


Oxide Nitric Oxide Biological Action Nitric Oxide Septic Shock 
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Copyright information

© Chapman & Hall 1995

Authors and Affiliations

  • Brendan J. R. Whittle
    • 1
  1. 1.Wellcome Foundation Limited, Langley CourtBeckenhamUK

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