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Nitric Oxide Signaling in Health and Disease

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Nitrite and Nitrate in Human Health and Disease

Part of the book series: Nutrition and Health ((NH))

Abstract

Nitric oxide has become one of the most studied molecules in medical history. Almost 30 years after the discovery of endothelium-derived relaxing factor as nitric oxide, there are now over 150,000 published papers on the chemistry and biology of nitric oxide. Over the past 30 years, we have learned much more about the production and regulation of NO as a ubiquitous signaling molecule in humans and other life forms. The first signaling pathway discovered from the oxidation of l-arginine and subsequent activation of soluble guanylyl cyclase by NO may only represent a fraction of the biological effects of NO. Understanding all the signaling aspects of NO will allow for better development of diagnostics and therapeutics.

The original version of this chapter was revised. An erratum to this chapter can be found at DOI 10.1007/978-3-319-46189-2_23

An erratum to this chapter can be found at http://dx.doi.org/10.1007/978-3-319-46189-2_23

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Authors and Affiliations

  1. Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, BCM225, Houston, TX, 77030, USA

    Nathan S. Bryan Ph.D.

  2. Departments of Pharmacology & Chemical Biology, Medicine, and Surgery, University of Pittsburgh School of Medicine, 200 Lothrop St., Pittsburgh, PA, 15261, USA

    Jack R. Lancaster Jr. Ph.D.

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  1. Nathan S. Bryan Ph.D.
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Correspondence to Nathan S. Bryan Ph.D. .

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Editors and Affiliations

  1. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA

    Nathan S. Bryan

  2. Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA

    Joseph Loscalzo

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Bryan, N.S., Lancaster, J.R. (2017). Nitric Oxide Signaling in Health and Disease. In: Bryan, N., Loscalzo, J. (eds) Nitrite and Nitrate in Human Health and Disease. Nutrition and Health. Humana Press, Cham. https://doi.org/10.1007/978-3-319-46189-2_13

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