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Anti-inflammatory effects of muramyl dipeptide in experimental models of acute inflammation

  • Immunosuppression and Inflammation
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Abstract

Synthetic muramyl dipeptide,N-acetylmuramyl-l-alanyl-d-isoglutamine (MDP), has been tested for activity against acute inflammation. In all models employed (Bayol + Arlacel paw oedema in rats, carrageenan pleurisy in rats, and carrageenan of dextran paw oedema in mice), MDP given in admixture with the phlogistic agents significantly lowered the resulting inflammatory reaction by about 30–40%. 0.1–0.2 mg of MDP per animal was applied. The mechanism of anti-inflammatory activity of this substance remains unknown.

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Authors and Affiliations

  1. Institute of Pharmacology, Czechoslovak Academy of Sciences, 128 00, Prague 2, Czechoslovakia

    Z. Zídek, K. Mašek & F. Šedivý

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  1. Z. Zídek
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  2. K. Mašek
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  3. F. Šedivý
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Zídek, Z., Mašek, K. & Šedivý, F. Anti-inflammatory effects of muramyl dipeptide in experimental models of acute inflammation. Agents and Actions 14, 72–75 (1984). https://doi.org/10.1007/BF01966836

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  • DOI: https://doi.org/10.1007/BF01966836

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