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Effect of Ester Derivative of Indomethacin on Immune Inflammation

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Bulletin of Experimental Biology and Medicine Aims and scope

The anti-inflammatory effect of the ester derivative of indomethacin (IML) in doses of 6.25, 12.5, and 25 mg/kg was studied in rats with modeled rheumatoid arthritis (adjuvant arthritis) and compared to the effects of the reference drug indomethacin in a dose of 1 mg/kg. IML in doses of 12.5 and 25 mg/kg reduced joint inflammation and promoted recovery of the microstructure of the synovial membrane and articular cartilage better than indomethacin. IML produced no ulcerogenic effect, while indomethacin concentration in the stomach wall after administration of IML was 1.8-3.4 times lower than after administration of the reference drug (p<0.05).

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Authors and Affiliations

  1. Siberian State Medical University, Ministry of Health of Russian Federation, Tomsk, Russia

    A. V. Bykova, V. V. Bykov & A. I. Vengerovskii

  2. Innovative Pharmacology Research Company, Tomsk, Russia

    A. V. Bykova, V. V. Bykov & S. A. Stankevich

  3. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia

    V. V. Udut

  4. National Research Tomsk State University, Tomsk, Russia

    V. V. Udut

Authors
  1. A. V. Bykova
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  2. V. V. Bykov
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  3. S. A. Stankevich
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  4. A. I. Vengerovskii
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  5. V. V. Udut
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Correspondence to V. V. Bykov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 170, No. 10, pp. 447-451, October, 2020

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Bykova, A.V., Bykov, V.V., Stankevich, S.A. et al. Effect of Ester Derivative of Indomethacin on Immune Inflammation. Bull Exp Biol Med 170, 440–443 (2021). https://doi.org/10.1007/s10517-021-05082-x

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  • DOI: https://doi.org/10.1007/s10517-021-05082-x

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