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Effect of clofibrate on the phospholipid biosynthesis in rat liver

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Summary

The effect of clofibrate on rat liver phospholipid biosynthesis was studied using32P as a precursor. Phospholipid classes, levels and specific radioactivity were evaluated. Significant increases in levels of phosphatidylethanolamine and phosphatidylcholine were found and could account for the observed increase in total phospholipids. Specific activity of phosphatidylserine increased and that of phosphatidylethanolamine decreased. This fact suggests that clofibrate seems to alter the systems engaged in the transformation occurring within the different classes of phospholipids but not the de novo biosynthesis.

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Author notes

  1. R. E. Catalán

    Present address: Departamento de Bioquímica, Facultad de Ciencias, Universidad de Madrid, Madrid-3, Spain

Authors and Affiliations

  1. Departmento de Investigación, Laboratorios Alter, Mateo Inurria 30, Madrid-16, Spain

    R. E. Catalán & M. P. Castillón

  2. Departamento de Bioquímica, Facultad de Ciencias, Universidad de Madrid, Madrid-3, Spain

    J. G. Priego

Authors
  1. R. E. Catalán
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  2. M. P. Castillón
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  3. J. G. Priego
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Catalán, R.E., Castillón, M.P. & Priego, J.G. Effect of clofibrate on the phospholipid biosynthesis in rat liver. Experientia 35, 859–860 (1979). https://doi.org/10.1007/BF01955111

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