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Effects of ethylp-chlorophenoxyisobutyrate on biliary secretion of bile acids, cholesterol and phosphatidyl choline

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Lipids

Abstract

The effect of chronic administration of ethylp-chlorophenoxyisobutyrate (CPIB) on the secretion of bile lipids was studied in four dogs with surgically implanted Thomas cannulae for periods of 2–7 months. The concentration of cholesterol, triglycerides andp-chlorophenoxyisobutyric acid in serum and of bile acids, cholesterol and phospholipids (phosphatidyl cholines) in bile were measured. Chronic administration of CPIB resulted in a marked increase in the concentration of cholesterol, bile acids and phosphatidyl cholines in the bile of all dogs, and a decrease in serum cholesterol and triglyceride concentration in serum in three of the four dogs. Serum concentrations ofp-chlorophenoxyisobutyric acid were monitored to insure the presence of the drug in the dogs; however, no correlation between serum levels ofp-chlorophenoxyisobutyric acid and the concentration of biliary lipids was noted. The bile acids andp-chlorophenoxyisobutyric acid were determined by gas chromatographic procedures and the structures were confirmed by gas chromatography-mass spectrometry.

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Authors and Affiliations

  1. Institute for Lipid Research, Baylor College of Medicine, 77025, Houston, Texas

    M. G. Horning, R. M. Hebert, R. J. Roth, D. L. Davis & E. C. Horning

  2. Department of Surgery, Baylor College of Medicine, 77025, Houston, Texas

    E. P. Fischer & G. L. Jordan Jr.

Authors
  1. M. G. Horning
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  2. R. M. Hebert
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  3. R. J. Roth
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  4. D. L. Davis
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  5. E. C. Horning
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  6. E. P. Fischer
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  7. G. L. Jordan Jr.
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Horning, M.G., Hebert, R.M., Roth, R.J. et al. Effects of ethylp-chlorophenoxyisobutyrate on biliary secretion of bile acids, cholesterol and phosphatidyl choline. Lipids 7, 114–120 (1972). https://doi.org/10.1007/BF02532598

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  • DOI: https://doi.org/10.1007/BF02532598

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