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Photon emission of phagocytes in relation to stress and disease

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Abstract

Phagocytes, the first-line cells of the body's defence mechanisms against invading pathogens, kill microorganisms by means of lysosomal degradative enzymes and highly toxic reactive oxygen intermediates. The reactive oxygen compounds are produced, in a process called the ‘respiratory burst’, by the NADPH oxidase complex in plasma membranes, and by myeloperoxidase in phagolysosomes after degranulation. These processes generate electronically excited states which, on relaxation, emit photons, giving rise to phagocyte chemiluminescence (CL). This paper describes the conditions for the measurement of CL, and reviews the activity of phagocytes from individuals undergoing stress or disease. The capability of phagocytes to emit photons reflects remarkably well the pathophysiological state of the host. In many cases even the magnitude of the stress, the presence of a pathogen in the body, or the activity of the disease can be estimated. Physiological changes, e.g. in the reproductive cycle, can also be predicted.

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References

  1. Abramson, J. S., Giebink, G. S., Mills, E. L., and Quie, P. G., Polymorphonuclear leukocyte dysfunction during influenza virus infection in chinchillas. J. infect. Dis.143 (1981) 836–845.

    Article  CAS  PubMed  Google Scholar 

  2. Abramson, J. S., Mills, E. L., Sawyer, M. K., Regelman, W. R., Nelson, J. D., and Quie, P. G., Recurrent infections and delayed separation of the umbilicar cord in an infant with abnormal phagocytic cell locomotion and oxidative response during particle phagocytosis. J. Ped.99 (1981) 887–894.

    Article  CAS  Google Scholar 

  3. Abramson, J. S., Giebink, G. S., and Quie, P. G., Influenza, a virusinduced polymorphonuclear leukocyte dysfunction in the pathogenesis of experimental pneumococcal otitis media. Infect. Immun.36 (1982) 289–296.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Abramson, J. S., Wagner, M. P., Ralston, E. P., Wei, Y., and Wheeler, J. G., The ability of polymorphonuclear leukocyte priming agents to overcome influenza, a virus-induced cell dysfunction. J. Leukocyte Biol.50 (1991) 160–165.

    Article  CAS  PubMed  Google Scholar 

  5. Adema, C. M., van Deutekom-Mulder, E. C., van der Knaap W. P. W., Meuleman, E. A., and Sminia, T., Generation of oxygen radicals in haemocytes of the snailLymnaea stagnalis in relation to the rate of phagocytosis. Dev. comp. Immun.15 (1991) 17–26.

    Article  CAS  Google Scholar 

  6. Adema, C. M., Harris, R. A., and van Deutekom-Mulder, E. C., A comparative study of hemocytes from six different snails morphology and functional aspects. J. Invert. Path.59 (1992) 24–32.

    Article  CAS  Google Scholar 

  7. Allen, R. C., Stjernholm, R. L., Reed, M. A., Harper, T. B., Gupta, S., Steele, R. H., and Waring, W. W., Correlation of metabolic and chemiluminescent responses of granulocytes from three female siblings with chronic granulomatous disease. J. immun. Dis.136 (1977) 510–518.

    CAS  Google Scholar 

  8. Allen, R. C., Mills, E. L., McNitt, T. R., and Quie, P. G., Role of myeloperoxidase and bacterial metabolism in chemiluminescence of granulocytes from patients with chronic granulomatous disease. J. infect. Dis.144 (1981) 344–348.

    Article  CAS  PubMed  Google Scholar 

  9. Andersen, O. K., Revhaug, A., Lundgren, T. I., and Giercksky, K.-E., Metabolic burst and motility in granulocytes following trauma and endotoxemia in the anaesthetized pig. Acta chir. scand.152 (1986) 641–645.

    CAS  PubMed  Google Scholar 

  10. Anderson, R., Theron, A. J., and Ras, G. J., Ascorbic acid neutralizes reactive oxidants released by hyperactive phagocytes from cigarette smokers. Lung166 (1988) 149–159.

    Article  CAS  PubMed  Google Scholar 

  11. Anderson, R., Theron, A. J., Richards, G. A., Myer, M. S., and van Rensburg, A. J., Passive smoking by humans sensitizes circulating neutrophils. Am. Rev. Respir. Dis.144 (1991) 570–574.

    Article  CAS  PubMed  Google Scholar 

  12. Angelidis, P., Baudin-Laurencin, F., and Youinou, P., Stress in rainbow troutSalmo gairdneri effects upon phagocyte chemiluminescence circulating leukocytes and susceptibility toAeromonas salmonicida. J. Fish Biol.31 (suppl. A) (1987) 113–122.

    Article  Google Scholar 

  13. Anton, P. A., Targan, S. R., and Shananan, F., Increased neutrophil receptors for and response to the proinflammatory bacterial peptide formyl-methionyl-leucyl-phenylalanine in Crohn's disease. Gastroenterology97 (1989) 20–28.

    Article  CAS  PubMed  Google Scholar 

  14. Bachere, E., Hervio, D., and Mialhe, E., Luminol dependent chemiluminescence by hemocytes of two marine bivalvesOstrea edulis andCrassostrea gigas. Dis. aquat. Org.11 (1991) 173–180.

    Article  Google Scholar 

  15. Barañao, R. I., Garberi, J. C., Tesone, P. A., and Rumi, L. S., Evaluation of neutrophil activity and circulating immune complexes leves in diabetic patients. Horm. Metab. Res.19 (1987) 371–374.

    Article  Google Scholar 

  16. Barañao, R. I., Rumi, L. S., Tesone, P. A., and Foglia, V. G., Some characteristics of neutrophils from diabetic patients and their relation to the levels of circulating immune complexes. Acta diabet. lat.25 (1988) 13–23.

    Article  Google Scholar 

  17. Barbour, A. G., Allred, C. D., Solberg, C. O., and Hill, H. R., Chemiluminescence by polymorphonuclear leukocytes from patients with active bacterial infection. J. infect. Dis.141 (1980) 14–26.

    Article  CAS  PubMed  Google Scholar 

  18. Bass, D. A., Olbrantz, P., Szedja, P., Seeds, M. C., and McCall, C. E., Subpopulations of neutrophils with increased oxidative product formation in blood of patients with infection. J. Immun.136 (1986) 860–866.

    Article  CAS  PubMed  Google Scholar 

  19. Bayne, C. J., and Levy, S., Modulation of the oxidative burst in trout myeloid cells by adrenocorticotropic hormone and catecholamines: mechanism of action. J. Leukocyte Biol.50 (1991) 554–560.

    Article  CAS  PubMed  Google Scholar 

  20. Bektas, S., Goetze, B., and Speer, C. P., Decreased adherence, chemotaxis and phagocytic activities of neutrophils from preterm neonates. Acta paediatr. scand.79 (1990) 1031–1038.

    Article  CAS  PubMed  Google Scholar 

  21. Bondestam, M., Håkansson, L., Foucard, T., and Venge, P., Defects in polymorphonuclear neutrophil function and susceptibility to infection in children. Scand. J. clin. Lab. Invest.46 (1986) 685–694.

    Article  CAS  PubMed  Google Scholar 

  22. Braun, D. P., Harris, J. E., Maximovich, S., Marder, R., and Lint, T. F., Chemiluminescence in peripheral blood mononuclear cells of solid tumor cancer patients. Cancer Immun. Immunother.12 (1981) 31–37.

    Article  Google Scholar 

  23. Braum, D. P., De Boer, K. P., and Harris, J. E., Chemiluminescence, suppression and cytotoxicity in peripheral blood mononuclear cells from solid tumor cancer patients. Cancer Immun. Immunother.14 (1982) 86–91.

    Article  Google Scholar 

  24. Busoni, P., Sarti, A., De Martino, M., Graziani, E., and Santoro, S., The effect of general and regional anesthesia on oxygen-dependent microbicidal mechanisms of polymorphonuclear leukocytes in children. Anesth. Analg.67 (1988) 453–456.

    Article  CAS  PubMed  Google Scholar 

  25. Calhoun, W. J., Salisbury, S. M., Chosy, L. W., and Busse, W. W., Increased alveolar macrophage chemiluminescence and airspace cell superoxide production in active pulmonary sarcoidosis. J. Lab. clin. Med.112 (1988) 147–156.

    CAS  PubMed  Google Scholar 

  26. Calhoun, W. J., Enhanced reactive oxygen species metabolism of air space cells in hypersensitivity pneumonitis. J. Lab. clin. Med.117 (1991) 443–452.

    CAS  PubMed  Google Scholar 

  27. Candido, A., Rossi, P., Meo, F., Lippa, S., Littarru, G., and De Sole, P., A whole blood chemiluminescence study in some hematological patients. Haematologica68 (1983) 478–486.

    CAS  PubMed  Google Scholar 

  28. Cassidy, L. F., Lyles, D. S., and Abramson, J. S., Depression of polymorphonuclear leukocyte functions by purified influenza virus hemagglutinin and sialic acid-binding lectins. J. Immun.142 (1989) 4401–4406.

    Article  CAS  PubMed  Google Scholar 

  29. Chusid, M. J., Shea, M. L., and Sarff, L. D., Determination of post-transfusion granulocyte kinetics by chemiluminescence in chronic granulomatous disease. J. Lab. clin. Med.95 (1980) 168–174.

    CAS  PubMed  Google Scholar 

  30. Chusid, M. J., Sohnle, P. G., Fink, J. N., and Shea, M. L., A genetic defect of granulocyte oxidative metabolism in a man with disseminated aspergillosis. J. Lab. clin. Med.97 (1981) 730–738.

    CAS  PubMed  Google Scholar 

  31. Cluzel, M., Damon, M., Chanez, P., Bouquet, J., De Paulet, A. C., Michel, F. B., and Godard, Ph., Enhanced alveolar cell luminol-dependent chemiluminescence in asthma. J. Allergy clin. Immun.80 (1987) 195–201.

    Article  CAS  PubMed  Google Scholar 

  32. Coble, B.-I., Dahlgren, C., Molin, L., and Stendahl, O., Neutrophil function in psoriasis: effects of retinoids. Acta dermatol. vener.67 (1987) 481–490.

    CAS  Google Scholar 

  33. Coble, B.-I., Brieheim, G., Dahlgren, C., and Molin, L., Function of exudate neutrophils from skin in psoriasis. Int. Archs Allergy appl. Immun.85 (1988) 398–403.

    Article  CAS  Google Scholar 

  34. Croft, K. D., Beilin, L. J., Vandongen, R., Rouse, J., and Masarei, J., Leukocyte and platelet function and eicosanoid production in subjects with hypercholesterolaemia. Atherosclerosis83 (1990) 101–109.

    Article  CAS  PubMed  Google Scholar 

  35. Dammacco, F., Miglietta, A., and Perfetto, S. C., Impaired chemiluminescence response by neutrophils in patients with multiple myeloma. Scand. J. Haemat.37 (1986) 289–295.

    CAS  PubMed  Google Scholar 

  36. DeChatelet, L. R., and Shirley, P. S., Evaluation of chronic granulomatous disease by a chemiluminescence assay of microliter quantities of whole blood. Clin. Chem.27 (1981) 1739–1741.

    Article  CAS  PubMed  Google Scholar 

  37. Descamps-Latscha, B., Nguyen, A. T., and Feutren, G., Phagocyte oxidative metabolism in cyclosporine-or placebo-treated patients with insulin-dependent (type I) diabetes mellitus of recent onset. J. Autoimmun.3 (1990) 201–213.

    Article  CAS  PubMed  Google Scholar 

  38. Dezzutti, C. S., Lafrado, L. J., Lewis, M. G., and Olsen, R. G., Inhibition of phorbol ester-induced neutrophil chemiluminescence by FeLV. Arch. Virol.111 (1990) 75–85.

    Article  CAS  PubMed  Google Scholar 

  39. Dikkeboom, R., van der Knaap, W. P. W., van den Bovenkamp, W., Tijnagel, J. M. G. H., and Bayne, C. J., The production of toxic oxygen metabolites by hemocytes of different snail species. Dev. comp. Immun.12 (1988) 509–520.

    Article  CAS  Google Scholar 

  40. Driscoll, M. S., Thomas, V. L., Ramamurthy, R. S., and Casto, D. T., Longitudinal evaluation of polymorphonuclear leukocyte chemiluminescence in premature infants. J. Pediatr.116 (1990) 429–434.

    Article  CAS  PubMed  Google Scholar 

  41. Edwards, S. W., Hart, C. A., Davies, J. M., Pattison, J., Hughes, V., and Sills, J. A., Case report. Impaired neutrophil killing in a patient with defective degranulation of myeloperoxidase. J. clin. Lab. Immun.25 (1988) 201–206.

    CAS  Google Scholar 

  42. Emergy, D. A., Nagaraja, K. V., Sivanandan, V., Lee, B. W., Zhang, C. L., and Newman, J. A., Endotoxin lipopolysaccharide fromEscherichia coli and its effects on the phagocytic function of systemic and pulmonary macrophages in turkeys. Avian Dis.35 (1991) 901–909.

    Article  Google Scholar 

  43. Engels, W., Grauls, G., Lemmens, P. J., Mullers, W. J., and Bruggeman, C. A., Influence of a cytomegalovirus infection on functions and arachidonic acid metabolism of rat peritoneal macrophages. J. Leukocyte Biol.45 (1989) 466–473.

    Article  CAS  PubMed  Google Scholar 

  44. van Epps, D. E., Goodwin, J. S., and Murphy, S., Age dependent variations in polymorphonuclear leukocyte chemiluminescence. Infect. Immun.22 (1978) 57–61.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Ertürk, M., Jennings, R., Oxley, K. M., and Hastings, M. J. G., Effect of influenza a on phagocytic cell function. Med. Microbiol. Immun.178 (1989) 199–209.

    Article  Google Scholar 

  46. Eschenbach, C., Chemilumineszenz phagocytierender neutrophiler Granulocyten von Neugeborenen mit bakteriellen Infektionen. Monatsschr. Kinderheilkd.129 (1981) 640–644.

    CAS  PubMed  Google Scholar 

  47. Estevez, M., Ballart, I. J., De Macedo, M. P., Magnasco, H., Nicastro, M. A., and Sen, L., Dysfunction of monocytes in Hodgkin's disease by excessive production of PGE-2 in long-term remission patients. Cancer62 (1988) 2128–2133.

    Article  CAS  PubMed  Google Scholar 

  48. Faden, H., and Rossi, T. M., Chemiluminescent response of neutrophils from patients with inflammatory bowel disease. Dig. Dis. Sci.30 (1985) 139–142.

    Article  CAS  PubMed  Google Scholar 

  49. Fisher, M., Upchurch, K. S., Levine, P. H., Johnson, M. H., Vaudreuil, C. H., Natale, A., and Hoogasian, J. J., Effects of dietary fish oil supplementation on polymorphonuclear leukocyte inflammatory potential. Inflammation10 (1986) 387–392.

    Article  CAS  PubMed  Google Scholar 

  50. Fisher, W. S., Wishkovsky, A., and Chu, F. E., Effects of tributyltin on defence-related activities of oyster hemocytes. Arch. envir. Contam. Toxic.19 (1990) 354–360.

    Article  CAS  Google Scholar 

  51. Flory, C. M., and Bayne, C. J., The influence of adrenergic and cholinergic agents on the chemiluminescent and mitogenic responses of leukocytes from the rainbow troutOncorhynchus mykiss. Dev. comp. Immun.15 (1991) 135–142.

    Article  CAS  Google Scholar 

  52. Follin, P., Brieheim, G., Sandstedt, S., and Dahlgren, C., Human neutrophil chemiluminescence and f-meth-leu-phe receptor exposure in bacterial infections. APMIS97 (1989) 585–590.

    Article  CAS  PubMed  Google Scholar 

  53. Frigieri, L., Di Mario, G., Fresu, R., Grilli, N., Pizzoli, C., Pagiari, G., and De Sole, P., Chemiluminescence of macrophages from bronchoalveolar lavage, in: Bioluminescence and Chemiluminescence. Current Status, pp. 281–284. Eds P. E. Stanley and L. J. Kricka. John Wiley & Sons, Chichester, England 1991.

    Google Scholar 

  54. Friis-Møller, A., and Kharazmi, A., Neutrophil response, serum opsonic activity, and precipitating antibodies in human infection withActinobacillus hominis. APMIS96 (1988) 1023–1028.

    Article  PubMed  Google Scholar 

  55. Gale, R., Bertouch, J. V., Bradley, J., and Roberts-Thompson, P. J., Direct activation of neutrophil chemiluminescence by rheumatoid sera and synovial fluid. Ann. rheum. Dis.42 (1983) 158–162.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  56. Graft, D. F., Mischler, E., Farrell, P. M., and Busse, W. W., Granulocyte chemiluminescence in adolescent patients with cystic fibrosis. Am. Rev. Respir. Dis.125 (1982) 540–543.

    Article  CAS  PubMed  Google Scholar 

  57. Gyllenhammar, H., Ringertz, B., Becker, W., Svensson, J., and Palmblad, J., Essential fatty acid deficiency in rats: effects on arachidonate metabolism, generation of cyclooxygenase products and functional responses in neutrophils. Immunology Lett.13 (1986) 185–189.

    Article  CAS  Google Scholar 

  58. Gyllenhammar, H., Palmblad, J., Ringertz, B., Hafström, I., and Borgeat, P., Rat neutrophil function, and leukotriene generation in essential fatty acid deficiency. Lipids23 (1988) 89–95.

    Article  CAS  PubMed  Google Scholar 

  59. Harmon, B. G., and Glisson, J. R., Disassociation of bactericidal and fungistatic activities from the oxidative burst of avian macrophages. Am. J. vet. Res.51 (1990) 71–75.

    CAS  PubMed  Google Scholar 

  60. Jacobs, R. F., Kiel, D. P., and Balk, R. A., Alveolar macrophage function in a canine model of endotoxin-induced lung injury. Am. Rev. Respir. Dis.134 (1986) 745–751.

    CAS  PubMed  Google Scholar 

  61. James, D. W., Betts, W. H., and Cleland, L. G., Chemiluminescence of polymorphonuclear leukocytes from rheumatoid joints. J. Rheumat.10 (1983) 184–189.

    CAS  Google Scholar 

  62. Kajita, Y., Sakai, M., Atsuta, S., and Kobayashi, M., The immunomodulatory effects of levamisole on rainbow troutOnchorhynchus mykiss. Fish Path.25 (1990) 93–98.

    Article  CAS  Google Scholar 

  63. Kalra, J., Chaundry, A. K., and Prasad, K., Increased production of oxygen free radicals in cigarette smokers. Int. J. exp. Path.72 (1991) 1–7.

    CAS  Google Scholar 

  64. Kankaanpää, A., and Lilius, E.-M., Leukocyte activity and the ovarian cycle. XXXIst International congress of physiological sciences, Helsinki, Finland, July 1991, p. 1442.

  65. Kantar, A., Wilkins, G., Swoboda, B., Littarru, G. P., Bertoli, E., Catassi, C., Coppa, G., and Giorgi, L., Alterations of the respiratory burst of polymorphonuclear leukocytes from diabetic children. Acta paediatr. scand.79 (1990) 535–541.

    Article  CAS  PubMed  Google Scholar 

  66. Kelleher, D., Feighery, C., and Weir, D. G., Chemiluminescence by polymorphonuclear leukocyte subpopulations in chronic inflammatory bowel disease. Digestion45 (1990) 158–165.

    Article  CAS  PubMed  Google Scholar 

  67. Kelly, C. A., Ward, C., Stenton, S. C., Hendrick, D. J., and Walters, E. H., Assessment of pulmonary macrophage and neutrophil function in sequential bronchoalveolar lavage aspirates in sarcoidosis. Thorax43 (1988) 787–791.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  68. Kiemle-Kallee, J., Kreipe, H., Radzun, H. J., Parwaresch, M. R., Auerswald, U., Magnussen, H., and Barth, J., Alveolar macrophages in idiopathic pulmonary fibrosis display a more monocyte like immunophenotype and an increased release of free oxygen radicals. Eur. J. Respir. Dis.4 (1991) 400–406.

    Article  CAS  Google Scholar 

  69. Kitahara, M., Eyre, H. J., Lynch, R. E., Rallison, M. L., and Hill, H. R., Metabolic activity of diabetic monocytes. Diabetes29 (1980) 251–256.

    Article  CAS  PubMed  Google Scholar 

  70. Kitahara, M., Eyre, H. J., Simonian, Y., Atkin, C. L., and Hasstedt, S. J., Hereditary myeloperoxidase deficiency. Blood57 (1981) 888–893.

    Article  CAS  PubMed  Google Scholar 

  71. Kitahora, T., Suzuki, K., Asakura, H., Yoshida, T., Suematsu, M., Watanabe, M., Aiso, S., and Tsuchiya, M., Active oxygen species generated by monocytes and polymorphonuclear cells in Crohn's disease. Dig. Dis. Sci.33 (1988) 951–955.

    Article  CAS  PubMed  Google Scholar 

  72. Kokot, K., Schaefer, R. M., Teschner, M., Gilge, U., Plass, R., and Heidland, A., Activation of leukocytes during physical exercise. Adv. exp. Med. Biol.240 (1988) 57–63.

    Article  CAS  PubMed  Google Scholar 

  73. Larson, K. G., Roberson, B. S., and Hetrick, F. M., Effect of environmental pollutants on the chemiluminescence of hemocytes from the American oysterCrassostrea virginica. Dis. aquat. Org.6 (1989) 131–136.

    Article  Google Scholar 

  74. Leino, L., Lilius, E.-M., Nikoskelainen, J., Pelliniemi, T.-T., and Rajamäki, A., Neutrophils are responsible for the reappearance of chemiluminescence after allogeneic bone marrow transplantation. Bone Marrow Transplant.6 (1990) 391–394.

    CAS  PubMed  Google Scholar 

  75. Leino, L., and Virkkunen, P., An automated chemiluminescence test for diagnosis of leukocytospermia. Int. J. Androl.14 (1991) 271–277.

    Article  CAS  PubMed  Google Scholar 

  76. Leirisalo-Repo, M., Lauhio, A., and Repo, H., Chemotaxis and chemiluminescence responses of synovial fluid polymorphonuclear leucocytes during acute reactive arthritis. Ann. rheum. Dis.49 (1990) 615–619.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  77. Lewis, M. G., Duska, G. O., Stiff, M. I., Lafrado, L. J., and Olsen, R. G., Polymorphonuclear leukocyte dysfunction associated with feline leukaemia virus infection. J. gen. Virol.67 (1986) 2113–2118.

    Article  PubMed  Google Scholar 

  78. Lilius, E.-M., Leukocytes as immunosensors, in: Biological Luminescence, pp. 449–459. Eds B. Jezowska-Trzebiatowska, B. Kochel, J. Slawinski and W. Strek. World Scientific, Singapore 1990.

    Google Scholar 

  79. Lilius, E.-M., Marnila, P., and Metsä-Ketelä, T., Effect of fish oil diet on the functions of rat leukocytes and heart. Xth Symposium of Food Chemistry, Triacyl Glycerols and Nutrition. University of Turku, Finland, 4./5.1. 1990.

    Google Scholar 

  80. Lilius, E.-M., Mäki, A.-L., Proskin, J., and Rajamäki, A., Leukocytes as immunosensors: Whole blood chemiluminescence (CL) in human leukaemias, in: Bioluminescence and Chemiluminescence. New Perspectives, pp. 53–56. Eds J. Schölmerlich, R. Andreesen, A. Kapp, M. Ernst and W. G. Woods. John Wiley & Sons, Chichester, England 1987.

    Google Scholar 

  81. Lilius, E.-M., Nykänen, J., and Ståhlberg, M.-R., Leukocytes as immunosensors: a screening method for food intolerances, in: Bioluminescence and Chemiluminescence. New Perspectives, pp. 145–148. Eds J. Schölmerlich, R. Andreesen, A. Kapp, M. Ernst and W. G. Woods. John Wiley & Sons, Chichester, England 1987.

    Google Scholar 

  82. Lilius, E.-M., and Pesonen, U.-M., Use of inflammatory cell activities in bovine milk to diagnose mastitis. Am. J. vet. Res.51 (1990) 1527–1533.

    CAS  PubMed  Google Scholar 

  83. Lindena, J., Burkhardt, H., and Dwenger, A., Mechanisms of nonopsonized zymosan-induced and luminol-enhanced chemiluminescence in whole blood and isolated phagocytes. J. clin. Chem. clin. Biochem.25 (1987) 765–778.

    CAS  PubMed  Google Scholar 

  84. Magaro, M., Altomonte, L., Zoli, A., Mirone, L., De Sole, P., Di Mario, G., Lippa, S., and Oradei, A., Influence of diet with different lipid composition on neutrophil chemiluminescence and disease activity in patients with rheumatoid arthritis. Ann. rheum. Dis.47 (1988) 793–796.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  85. Majima, T., Minegishi, N., Nagatomi, R., Ohashi, Y., Tsuchiya, S., Kobayashi, K., and Konno, T., Unusual expression of IgG Fc receptors on peripheral granulocytes from patients with leukocyte adhesion deficiency (CD11/CD18). J. Immun.145 (1990) 1694–1699.

    Article  CAS  PubMed  Google Scholar 

  86. Marnila, P. J., Lagerspetz, K. Y. H., and Lilius, E.-M., Leukocyte activity and thermoregulation. XXXIst International congress of physiological sciences, Helsinki, Finland, July 1991, p. 3576.

  87. Martin, R. R., Lawrence, E. C., Teague, R. B., Gottlieb, M. S., and Putman, M., Chemiluminescence of lung macrophages and blood leukocytes in sarcoidosis. Am. Rev. Respir. Dis.133 (1986) 298–301.

    CAS  PubMed  Google Scholar 

  88. McCarthy, J. P., Bodroghy, R. S., Jahrling, P. B., and Sobocinski, P. Z., Differential alterations in host peripheral polymorphonuclear leukocyte chemiluminescence during the course of bacterial and viral infections. Infect. Immun.30 (1980) 824–831.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  89. Mealy, K., O'Farrelly, C., Stephens, R., and Freighery, C., Impaired neutrophil function during anesthesia and surgery is due to serum factors. J. Surg. Res.43 (1987) 393–397.

    Article  CAS  PubMed  Google Scholar 

  90. Michel, F., Rudent, A., Labarre, C., Quero, A. M., Zalisz, R., and Smets, P., Effects of RU 41740 aerosol treatment on mouse bronchoalveolar cells, and protection afforded against influenza virus infection. Int. J. Immunopharmac.9 (1987) 775–781.

    Article  CAS  Google Scholar 

  91. Mills, E. L., Thompson, T., Björksten, B., Filipovich, D., and Quie, P. G., The chemiluminescence response and bactericidal activity of polymorphonuclear neutrophils from newborns and their mothers. Pediatrics63 (1979) 429–434.

    Article  CAS  PubMed  Google Scholar 

  92. Mills, E. L., Rholl, K. S., and Quie, P. G., Luminol-amplified chemiluminescence: a sensitive method for detecting the carrier state in chronic granulomatous disease. J. clin. Microbiol.12 (1980) 52–56.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  93. Miyata, H., Moriguchi, N., and Kinoshita, T., The chemiluminescence response of polymorphonuclear leukocytes from febrile patients. Clin. chim. Acta173 (1988) 337–342.

    Article  CAS  PubMed  Google Scholar 

  94. Nutter, R. L., Kettering, J. D., Aprecio, R. M., Weeks, D. A., and Gridley, D. S., Effects of dietary fat and protein on DMH-induced tumor development and immune responses. Nutr. Cancer13 (1990) 141–152.

    Article  CAS  PubMed  Google Scholar 

  95. O'Neill, B., and Leonard, B. E., Abnormal zymosan-induced neutrophil chemiluminescence as a marker of depression. J. affect. Disord.19 (1990) 265–272.

    Article  CAS  PubMed  Google Scholar 

  96. Okabe, N., Kuroiwa, A., Fujita, K., Shibuya, T., Yao, T., and Okomura, M., Immunological studies on Crohn's disease VI. Increased chemiluminescent response of peripheral blood monocytes. J. clin. Lab. Immun.21 (1986) 11–15.

    CAS  Google Scholar 

  97. Pauksens, K., Sjöling, J., and Venge, P., Chemiluminescence of polymorphonuclear leukocytes and whole blood during acute bacterial infection. Scand. J. infect. Dis.21 (1989) 277–284.

    Article  CAS  PubMed  Google Scholar 

  98. Peden, D. B., Van Dyke, K., Ardekani, A., Mullett, M. D., Myerberg, D. Z., and Van Dyke, C., Diminished chemiluminescent responses of polymorphonuclear leukocytes in severely and moderately preterm neonates. J. Pediatr.6 (1987) 904–906.

    Article  Google Scholar 

  99. Pedersen, B. K., Tvede, N., Klarlund, K., Christensen, L. D., Hansen, F. R., Galbo, H., Kharazmi, A., and Halkjär-Kristensen, J., Indomethacin in vitro and in vivo abolishes post-exercise suppression of natural killer cell activity in peripheral blood. Int. J. Sports Med.11 (1990) 127–131.

    Article  CAS  PubMed  Google Scholar 

  100. Perttilä, J., Lehtonen, O.-P., Salo, M., and Tertti, R., Effects of coronary bypass surgery under high-dose fentanyl anaesthesia on granulocyte chemiluminescence. Br. J. Anaesth.58 (1986) 1027–1030.

    Article  PubMed  Google Scholar 

  101. Perttilä, J., Lilius, E.-M., and Salo, M., Effects of anaesthesia and surgery on serum opsonic capacity. Acta anaesth. scand.30 (1986) 173–176.

    Article  PubMed  Google Scholar 

  102. Perttilä, J., Salo, M., Peltola, O., and Irjala, K., Changes in granulocyte chemiluminescence and plasma fibronectin concentrations following major blunt trauma. Eur. Surg. Res.20 (1988) 211–219.

    Article  PubMed  Google Scholar 

  103. Plytycz, B., and Bayne, C. J., PMA-induced chemiluminescence of amphibian leukocytes. Dev. comp. Immun.11 (1987) 245–250.

    Article  CAS  Google Scholar 

  104. Rajamäki, A., Lilius, E.-M., Nikoskelainen, J., Proskin, J., Salmi, T. T., and Toivanen, A., Luminol enhanced chemiluminescence of peripheral blood leukocytes as an early indicator of graft take after allogeneic bone marrow transplantation in patients with acute myelogenous leukemia. Med. Oncol. Tumor Pharmacother.5 (1988) 99–102.

    Article  PubMed  Google Scholar 

  105. Regelmann, W. E., Lunde, N. M., Porter, P. T., and Quie, P. G., Increased monocyte chemiluminescence in cystic fibrosis patients and in their parents. Ped. Res.20 (1986) 619–622.

    Article  CAS  Google Scholar 

  106. Richards, G. A., Theron, A. J., van der Merwe, C. A., and Anderson, R., Spirometric abnormalities in young smokers correlate with increased chemiluminescence responses of activated blood phagocytes. Am. Rev. Respir. Dis.139 (1989) 181–187.

    Article  CAS  PubMed  Google Scholar 

  107. Richards, G. A., Theron, A. J., van Rensburg, C. E. J., van Rensburg, A. J., van der Merwe, C. A., Kuyl, J. M., and Anderson, R., Investigation of the effects of oral administration of vitamin E and beta-carotene on the chemiluminescence responses and the frequency of sister chromatid exchanges in circulating leukocytes from cigarette smokers. Am. Rev. Respir. Dis.142 (1990) 648–654.

    Article  CAS  PubMed  Google Scholar 

  108. Roberts, R. L., and Stiehm, E. R., Increased phagocytic cell chemiluminescence in patients with cystic fibrosis. Am. J. Dis. Child.143 (1989) 944–950.

    CAS  PubMed  Google Scholar 

  109. Rosen, H., and Klebanoff, S. J., Chemiluminescence and superoxide production by myeloperoxidase-deficient leukocytes. J. clin. Invest.58 (1976) 50–60.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  110. Rudent, A., Michel, F., Labarre, C., Quero, A. M., Zalisz, R., and Smets, P., Enhancement of broncoalveolar cell recovery and stimulation of alveolar macrophage chemiluminescence and resistance to influenza virus after treatment with RU 41821 aerosol. Antimicrob. Agents Chemother.31 (1987) 920–924.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  111. Røkke, O., Revhaug, A., and Giercksky, K.-E., Polymorphonuclear leukocytes activation after trauma: evidence for increased generation of oxygen free radicals in responce to in vitro endotoxin stimulation. Acta chir. scand.155 (1989) 233–239.

    PubMed  Google Scholar 

  112. Sakai, M., Kamiya, H., Atsuta, S., and Kobayashi, M., Immunomodulatory effects on rainbow troutOncorhynchus mykiss injected with the extract ofAbalone haliotis discushannai. J. appl. Ichtyol.7 (1991) 54–59.

    Article  Google Scholar 

  113. Salo, M., Perttilä, J., and Lehtonen, O.-P., Granulocyte chemiluminescence in patients with postoperative infections. Arch. Surg.123 (1988) 17–22.

    Article  CAS  PubMed  Google Scholar 

  114. Schopf, R. E., and Straussfeld, E., Stimulus-dependent increased generation of oxygen intermediates in monocytes and polymorphonuclear leukocytes in psoriasis. J. Invest. Dermat.84 (1985) 73–76.

    Article  CAS  Google Scholar 

  115. Selvaraj, R. J., Sbarra, A. J., Thomas, G. B., Cetrulo, C. L., and Mitchell, G. W., A microtechnique for studying chemiluminescence response of phagocytes using whole blood and its application to the evaluation of phagocytes in pregnancy. J. Reticuloendot. Soc.31 (1982) 3–16.

    CAS  Google Scholar 

  116. Sheng, C. Y., and Tung, Y. L., Neutrophil chemiluminescence in burned patients. J. Trauma27 (1987) 587–595.

    Article  CAS  PubMed  Google Scholar 

  117. Shibuya, T., Izuchi, K., Kuroiwa, A., Okabe, N., and Shirakawa, K., Study on nonspecific immunity in pregnant women: increased chemiluminescence response of peripheral blood phagocytes. Am. J. Reprod. Immun. Microbiol.15 (1987) 19–23.

    Article  CAS  Google Scholar 

  118. Shigeoka, A. O., and Hill, H. R., Case report. Recurrent pseudomonas infection associated with neutrophil dysfunction. Scand. J. infect. Dis.10 (1978) 307–311.

    Article  CAS  PubMed  Google Scholar 

  119. Shigeoka, A. O., Charette, R. P., Wyman, M. L., and Hill, H. R., Defective oxidative metabolic responses of neutrophils from stressed neonates. J. Pediatr.3 (1981) 392–398.

    Article  Google Scholar 

  120. de Simone, C., de Sole, P., di Mario, G., Venier, A., Cerimele, D., and Serri, F., Reactive oxygen species production in circulating polymorphonuclear leukocytes in psoriasis. Acta dermat. vener.146 (1989) 50–52.

    Google Scholar 

  121. Smith, J. A., Telford, R. D., Mason, I. B., and Weideman, M. J., Exercise, training and neutrophil microbicidal activity. Int. J. Sports Med.11 (1990) 179–187.

    Article  CAS  PubMed  Google Scholar 

  122. Solberg, C. O., Kalager, T., Hill, H. R., and Glette, J., Polymorphonuclear leukocyte function in bacterial and viral infections. Scand. J. infect. Dis.14 (1982) 11–18.

    Article  CAS  PubMed  Google Scholar 

  123. Stave, J. W., Cook, T. M., and Robertson, B. S., Chemiluminescent responses of striped bassMorone saxatilis walbaum phagocytes to strains ofYersinia ryckeri. J. Fish Dis.10 (1987) 1–10.

    Article  Google Scholar 

  124. Suematsu, M., Suzuki, M., Kitahora, T., Miura, S., Suzuki, K., Hibi, T., Watanabe, M., Nagata, H., Asakura, H., and Tsuchiya, M., Increased respiratory burst of leukocytes in inflammatory bowel disease-the analysis of free radical generation by using chemiluminescence probe. J. clin. Lab. Immun.24 (1987) 125–128.

    CAS  Google Scholar 

  125. Toivanen, A., Nikoskelainen, J., Lilius, E.-M., Salmi, T. T., Kätkä, K., Pelliniemi, T.-T., Mäki, A.-L., and Rajamäki, A., Peripheral blood chemiluminescence as an early indicator of successful bone marrow transplantation. Transplant. Proc.19 (1987) 2745–2746.

    CAS  PubMed  Google Scholar 

  126. Tono-oka, T., Matsumoto, T., Ueno, N., Yashiki, N., and Matsumoto, S., Chemiluminescence of whole blood. II. Application to clinical examination of phagocytic functions of whole blood from various types of disease. Clin. Immun. Immunopath.29 (1983) 333–340.

    Article  CAS  PubMed  Google Scholar 

  127. Trulson, A., Nilsson, S., and Venge, P., Lucigenin-enhanced chemiluminescence in blood is increased in cancer. Am. J. clin. Path.91 (1989) 441–445.

    Article  CAS  PubMed  Google Scholar 

  128. Tullgren, O., Giscombe, R., Holm, G., Johansson, B., Ellstedt, H., and Björkholm, M., Increased luminol-enhanced chemiluminescence of blood monocytes and granulocytes in Hodgkin's disease. Clin. exp. Immun.85 (1991) 436–440.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  129. Usmani, S. S., Schlessel, J. S., Sia, C. G., Kamran, S., and Orner, S. D., Polymorphonuclear leukocyte function in the preterm neonate: effect of chronologic age. Pediatrics87 (1991) 675–679.

    Article  CAS  PubMed  Google Scholar 

  130. Wallaert, B., Ramon, P., Fournier, E. C., Prin, L., Tonnel, A. B., and Voisin, C., Activated alveolar macrophage and lymphocyte alveolitis in extrathoracic sarcoidosis without radiological mediastinopulmonary involvement. Ann. N.Y. Acad. Sci.465 (1986) 201–210.

    Article  CAS  PubMed  Google Scholar 

  131. Wallaert, B., Bonniere, B., Prin, L., Cortot, A., Tonnel, A. B., and Voisin, C., Primary biliary cirrhosis. Subclinical inflammatory alveolitis in patients with normal chest roentgenograms. Chest90 (1986) 842–848.

    Article  CAS  PubMed  Google Scholar 

  132. Weening, R. S., Corbeel, L., de Boer, M., Lutter, R., van Zwieten, R., Hamers, M. N., and Roos, D., Cytochrome b deficiency in an autosomal form of chronic granulomatous disease. J. clin. Invest.75 (1985) 915–920.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  133. Winocour, P. H., Lenton, J., Puxty, J. A. H., and Anderson, D. C., Leukocyte microbicidal activity assessed by chemiluminescence in elderly non-insulin dependent diabetes mellitus. Diabetes Res.9 (1988) 73–75.

    CAS  PubMed  Google Scholar 

  134. Wishkovsky, A., Robertson, B. S., and Hetrick, F. M., In-vitro suppression of the phagocytic response of fish macrophages by tetracyclines. J. Fish Biol.31 (suppl. A) (1987) 61–66.

    Article  CAS  Google Scholar 

  135. Wishkovsky, A., Mathews, E. S., and Weeks, B. A., Effect of tributyltin on the chemiluminescent response of phagocytes from three species of estuarine fish. Arch. envir. Contam. Toxic.18 (1989) 829–831.

    Google Scholar 

  136. Wong, C. W., Thompson, H. L., Thong, Y. H., and Thornton, J. R., Effects of strenous exercise stress on chemiluminescence response of equine alveolar macrophages. Equine vet. J.22 (1990) 33–35.

    Article  CAS  PubMed  Google Scholar 

  137. Yamada, F., Kodama, H., Mikami, T., and Izawa, H., Chemiluminescence of rainbow troutSalmo gairdneri phagocytes and factors affecting their response. Jap. J. vet. Sci.50 (1988) 1092–1098.

    Article  CAS  Google Scholar 

  138. Yoshida, T., and Kitao, T., The opsonic effect of specific immune serum on the phagocytic and chemiluminescent response in rainbow troutOnchorhynchus mykiss phagocytes. Fish Path.26 (1991) 29–34.

    Article  CAS  Google Scholar 

  139. Zeidler, R. B., and Kim, H. D., Phagocytosis, chemiluminescence, and cell volume of alveolar macrophages from neonatal and adult pigs. J. Leukocyte Biol.37 (1985) 29–43.

    Article  CAS  PubMed  Google Scholar 

  140. Zeller, J. M., Henig, I., Radwanska, E., and Dmowski, W. P., Enhancement of human monocyte and peritoneal macrophage chemiluminescence activities in women with endometriosis. Am. J. Reprod. Immun. Microbiol.13 (1987) 78–82.

    Article  CAS  Google Scholar 

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    E. M. Lilius & P. Marnila

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Lilius, E.M., Marnila, P. Photon emission of phagocytes in relation to stress and disease. Experientia 48, 1082–1091 (1992). https://doi.org/10.1007/BF01947995

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