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Neurochemical Research

, Volume 17, Issue 4, pp 387–395 | Cite as

Regional distribution of monoamines and dopamine D1-and D2-receptors in the striatum of the rat

  • V. A. Russell
  • R. Allin
  • M. C. L. Lamm
  • J. J. F. Taljaard
Original Articles

Abstract

Dopamine (DA) D1-and D2-receptor densities were determined in 18 discrete areas of the caudate-putamen-globus pallidus of male Wistar rats and compared to local DA concentrations. All three parameters were found to decrease caudally. The globus pallidus was distinguished by the low concentration of DA and its receptors and high noradrenaline, (NA) content. While there were no mediolateral differences in DA or DA D1-receptors, a clear mediolateral gradient was observed for DA D2-receptors which extended over several sections of the brain. The ratio of DA D1-to D2-receptors was significantly higher in the dorsal than in the ventral areas of the mediolateral and caudal striatum. This is the first report of clear dorsoventral differences in parameters relating to DA activity in the striatum. These findings may be of particular significance in understanding the functional dichotomy between the dorsal and ventral striatum.

Key Words

Dopamine D1-receptor D2-receptor monoamines striatum regional distribution 

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Copyright information

© Plenum Publishing Corporation 1992

Authors and Affiliations

  • V. A. Russell
    • 1
  • R. Allin
    • 1
  • M. C. L. Lamm
    • 1
  • J. J. F. Taljaard
    • 1
  1. 1.MRC Research Unit for the Neurochemistry of Mental, Diseases, Department of Chemical PathologyUniversity of Stellenbosch, Tygerberg HospitalTygerbergRepublic of, South Africa

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