Skip to main content
SpringerLink
Log in

Regional distribution of monoamines and dopamine D1-and D2-receptors in the striatum of the rat

  • Original Articles
  • Published:
Neurochemical Research Aims and scope Submit manuscript

Abstract

Dopamine (DA) D1-and D2-receptor densities were determined in 18 discrete areas of the caudate-putamen-globus pallidus of male Wistar rats and compared to local DA concentrations. All three parameters were found to decrease caudally. The globus pallidus was distinguished by the low concentration of DA and its receptors and high noradrenaline, (NA) content. While there were no mediolateral differences in DA or DA D1-receptors, a clear mediolateral gradient was observed for DA D2-receptors which extended over several sections of the brain. The ratio of DA D1-to D2-receptors was significantly higher in the dorsal than in the ventral areas of the mediolateral and caudal striatum. This is the first report of clear dorsoventral differences in parameters relating to DA activity in the striatum. These findings may be of particular significance in understanding the functional dichotomy between the dorsal and ventral striatum.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Barr, M. L. and Kiernan, J. A. 1983. The human nervous system. An anatomical viewpoint. Pages 204–212, 4th edn., Harper and Row, Philadelphia.

    Google Scholar 

  2. Dunnett, S. B., and Iversen, S. D. 1982. Regulatory impairments following selective 6-OHDA lesions of the neostriatum Behav. Brain Res. 4:195–202.

    PubMed  Google Scholar 

  3. Dunnett, S. B., and Iversen, S. D. 1982. Sensorimotor impairments following localized kainic acid and 6-hydroxydopamine lesions of the neostriatum. Brain Res. 248:121–127.

    PubMed  Google Scholar 

  4. Graybiel, A. M. 1984. Neurochemically specified subsystems in the basal ganglia. Pages 114–149,in Evered, D. and O'Connor, M. (eds.), Functions of the basal ganglia, Pitman, London.

    Google Scholar 

  5. Nauta, W. J. H., and Domesick, V. B. 1984. Afferent and efferent relationships of the basal ganglia. Pages 3–29,in Evered, D. and O'Connor, M. (eds.), Functions of the basal ganglia, Pitman, London.

    Google Scholar 

  6. Chandler, C. J., Starr, B. S., and Starr, M. S., 1990. Differential behavioural interactions between the dopamine D-1 antagonist SCH 23390 and the dopamine D-2 antagonists metoclopramide and sulpiride in nonhabituated mice. Pharmacol. Biochem. Behav. 35:285–289.

    PubMed  Google Scholar 

  7. Koshikawa, N., Tomiyama, K., Omiya, K., de Beltran, K. K., and Kobayashi, M. 1990. Dopamine D-1 but not D-2 receptor stimulation of the dorsal striatum potentiates apomorphine-induced jaw movements in rats. Eur. J. Pharmacol. 178:189–194.

    PubMed  Google Scholar 

  8. Konitsiotis, S., and Kafetzopoulos, E. 1990. Topography of dopamine D-1 and D-2 receptor-mediated rotation after intrastriatal injections of dopamine-related drugs in normosensitive rats. Eur. J. Pharmacol. 179:201–205.

    PubMed  Google Scholar 

  9. Joyce, J. N., Loeschen, S. K., and Marshall, J. F. 1985. Dopamine D-2 receptors in rat caudate putamen: the lateral to medial gradient does not correspond to dopaminergic innervation. Brain Res. 338:209–218.

    PubMed  Google Scholar 

  10. Beal, M. F., and Martin, J. B. 1985. Topographical dopamine and serotonin distribution and turnover in rat striatum. Brain Res. 358:10–15.

    PubMed  Google Scholar 

  11. Allin, R., Russell, V. A., Lamm, M. C. L., and Taljaard, J. J. F. 1988. Regional distribution of monoamines in the nucleus accumbens of the rat. Neurochem. Res. 13:937–942.

    PubMed  Google Scholar 

  12. Allin, R., Russell, V. A., Lamm, M. C. L., and Taljaard, J. J. F. 1989. Regional distribution of dopamine D1 and D2 receptors in the nucleus accumbens of the rat. Brain Res. 501:389–391.

    PubMed  Google Scholar 

  13. Russell, V. A., Allin, R., Lamm, M. C. L., and Taljaard., J. J. F. 1989. Increased dopamine D2 receptor-mediated inhibition of [14C]acetylcholine release in the dorsomedial part of the nucleus accumbens. Neurochem. Res. 14:877–881.

    PubMed  Google Scholar 

  14. Pellegrino, L. J., Pellegrino, A. S., and Cushman, A. J. 1979. A stereotaxic atlas of the rat brain. Plenum Press, New York.

    Google Scholar 

  15. KcKay, L., Bradberry, C., and Oke, A. 1984. Ascorbic acid oxidase speeds up analysis for catecholamines, indoleamines and their metabolites in brain tissue using high-performance liquid chromatography with electrochemical detection. J. Chromatog. 311:167–169.

    Google Scholar 

  16. Reyneke, L., Allin, R., Russell, V. A., and Taljaard, J. J. F. 1989. Lack of effect of chronic desipramine treatment on dopaminergic activity in the nucleus accumbens of the rat. Neurochem. Res. 14:661–665.

    Google Scholar 

  17. Billard, W. Ruperto, V., Crosby, G., Iorio, L. C., and Barnett, A. 1984. Characterization of the binding of [3H]SCH 23390, a selective D-1 receptor antagonist ligand, in rat striatum. Life Sci. 35:1885–1893.

    PubMed  Google Scholar 

  18. Leysen, J. E., and Gommeren, W. 1981. Optimal conditions for [3H]apomorphine binding and anomalous equilibrium binding of [3H]apomorphine and [3H]spiperone to rat striatal membranes: involvement of surface phenomena versus multiple binding sites. J. Neurochem. 36:201–209.

    PubMed  Google Scholar 

  19. Munson, P. J., and Rodbard, D. 1980. LIGAND: A versatile computerized approach for characterization of ligand-binding systems. Anal. Biochem. 107:220–239.

    PubMed  Google Scholar 

  20. Lowry O. H., rosebrough, N. J., Farr, A. L., and Randall, R. 1951. Protein measurement with the folin phenol reagent. J. Biol. Chem. 193:265–275.

    PubMed  Google Scholar 

  21. Tassin, J. P., Cheramy, A., Blanc, G., Thierry, A. M., and Glowinski, J. 1976. Topographical distribution of dopaminergic innervation and of dopaminergic receptors in the rat striatum. I. Microestimation of [3H]dopamine uptake and dopamine content in microdiscs. Brain Res. 107:291–301.

    PubMed  Google Scholar 

  22. Doucet, G., Descarries, L., and Garcia, S. 1986. Quantification of the dopamine innervation in adult rat neostriatum. Neuroscience 19:427–445.

    PubMed  Google Scholar 

  23. Hardy, J. A., Wester, P., Backstrom I., Gottfries, J., Orelands, L., Stenstrom, A., and Winblad, B. 1987. The regional distribution of dopamine and serotonin uptake and transmitter concentrations in the human brain. Neurochem. Int. 10:445–450.

    Google Scholar 

  24. Versteeg, D. H. G., van der Gugten, J., de Jong, W., and Palkovits, M. 1976. Regional concentrations of noradrenaline and dopamine in the rat brain. Brain Res. 113:563–574.

    PubMed  Google Scholar 

  25. Lindvall, O., and Bjorklund, A. 1978. Organization of catecholamine neurons in the rat central nervous system. Pages 139–231,in Iversen, L. L., Iversen, S. D. and Snyder, S. H. (eds.), Handbook of Psychopharmacology, Vol. 9, Plenum Press, New York.

    Google Scholar 

  26. Walsh, F. X., Stevens, T. J., Langlais, P. J., and Bird, E. D. 1981. Dopamine and homovanillic acid concentrations in striatal and limbic regions of human brain. Annal. Neurol. 12:52–55.

    Google Scholar 

  27. Jones, B. E., and Moore, R. Y. 1977. Ascending projections of the locus coeruleus in the rat. II. Autoradiographic study. Brain Res. 127:23–53.

    Google Scholar 

  28. Lindvall, O., and Bjorklund, A. 1974. The organization of the ascending catecholamine neuron systems in the rat brain. Acta Physiol. Scand. Suppl. 412:1–48.

    Google Scholar 

  29. O'Donohue, T. L., Crowley, W. R., and Jacobowitz, D. M. 1979. Biochemical mapping of the noradrenergic ventral bundle projection sites: evidence for a noradrenergic-dopaminergic interaction. Brain Res. 172:87–100.

    PubMed  Google Scholar 

  30. Byrum, C. E., and Guyenet, P. G. 1987. Afferent and efferent connections of the A5 noradrenergic cell group in the rat. J. Comp. Neurol. 261:529–542.

    PubMed  Google Scholar 

  31. Soghomonian, J.-J., Doucet, G., and Descarries, L. 1987. Serotonin innervation in adult rat neostriatum. I. Quantified regional distribution. Brain Res. 425:85–100.

    PubMed  Google Scholar 

  32. Savasta, M., Dubois, A., and Scatton, B. 1986. Autoradiographic localization of D1 dopamine receptors in the rat brain with [3H]SCH 23390. Brain Res. 375:291–301.

    PubMed  Google Scholar 

  33. Dubois, A., and Scatton, B. 1985. Heterogeneous distribution of dopamine D2 receptors within the rat striatum as revealed by autoradiography of [3H]N-n-propylnorapomorphine binding sites. Neurosci. Lett. 57:7–12.

    PubMed  Google Scholar 

  34. Stamford, J. A., Kruk, Z. L., and Millar, J. 1990. No mediolateral differences in striatal autoreceptor-mediated modulation of dopamine release: in vivo voltammetric data. Neurosci. Lett. 109:123–127.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. MRC Research Unit for the Neurochemistry of Mental, Diseases, Department of Chemical Pathology, University of Stellenbosch, Tygerberg Hospital, P.O. Box 19113, 7505, Tygerberg, Republic of, South Africa

    V. A. Russell, R. Allin, M. C. L. Lamm & J. J. F. Taljaard

Authors
  1. V. A. Russell
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Allin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. C. L. Lamm
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. J. F. Taljaard
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Russell, V.A., Allin, R., Lamm, M.C.L. et al. Regional distribution of monoamines and dopamine D1-and D2-receptors in the striatum of the rat. Neurochem Res 17, 387–395 (1992). https://doi.org/10.1007/BF00974582

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00974582

Key Words

Search

Navigation