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Hints on the Lateralization of Dopamine Binding to D1 Receptors in Rat Striatum

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Abstract

Dopamine receptors in striatum are important for healthy brain functioning and are the target of levodopa-based therapy in Parkinson’s disease. Lateralization of dopaminergic neurotransmission in striata from different hemispheres occurs in patients, but also in healthy individuals. Our data show that the affinity of dopamine binding to dopamine D1 receptors is significantly higher in left than in right striatum. Analysis of data from radioligand binding to striatal samples from naïve, 6-hydroxydopamine lesioned, levodopa-treated and levodopa-induced dyskinetic rats shows differential receptor structure and gives hints on the causes of right/left lateralization of dopamine binding to striatal D1 receptors. Moreover, binding data showed loss of lateralization in levodopa (L-DOPA)-induced dyskinetic rats.

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Acknowledgments

This work was supported by grants from Spanish Ministerio de Ciencia y Tecnología (SAF2009-07276, SAF2011-23813, and SAF2012-39875-C02-01) and from Spanish Ministerio de Salud (PI09/01756). MMP is supported by Marie Curie CIG PCIG11-GA-2012-322013.

Conflict of Interest

The authors declare no conflict of interest.

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Authors and Affiliations

  1. Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Valderrebollo 5, 28031, Madrid, Spain

    Rafael Franco, Verònica Casadó-Anguera, Ana Muñoz, Gemma Navarro, Estefanía Moreno, José Luis Lanciego, José Luis Labandeira-García, Antoni Cortés & Vicent Casadó

  2. Molecular Neurobiology Laboratory, Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, 08028, Barcelona, Spain

    Rafael Franco, Verònica Casadó-Anguera, Gemma Navarro, Estefanía Moreno, Antoni Cortés & Vicent Casadó

  3. Laboratory of Neuroanatomy and Experimental Neurology, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela, 15782, Santiago de Compostela, Spain

    Ana Muñoz & José Luis Labandeira-García

  4. School of Pharmacy and Biomedical Sciences, University of Central Lancashire, PR1 2HE, Preston, UK

    Milos Petrovic

  5. Institute of Physiology, Academy of Sciences, Videnska 1083, 14220, Prague, Czech Republic

    Milos Petrovic

  6. Laboratory of Neuroanatomy of Basal Ganglia, Neurosciences Division, Center for Applied Medical Research (CIMA), University of Navarra, 31008, Pamplona, Spain

    José Luis Lanciego

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  1. Rafael Franco
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  2. Verònica Casadó-Anguera
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Correspondence to Rafael Franco.

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Franco, R., Casadó-Anguera, V., Muñoz, A. et al. Hints on the Lateralization of Dopamine Binding to D1 Receptors in Rat Striatum. Mol Neurobiol 53, 5436–5445 (2016). https://doi.org/10.1007/s12035-015-9468-8

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  • DOI: https://doi.org/10.1007/s12035-015-9468-8

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