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Synthesen von Siebenerringsystemen aus substituierten Isothiocyanaten und Hydrazinen

Syntheses of seven-membered heterocycles from substituted isothiocyanates and hydrazines

  • Organische Chemie und Biochemie
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Monatshefte für Chemie / Chemical Monthly Aims and scope Submit manuscript

Abstract

The β-isothiocyanato-ketone 1 reacts with substituted hydrazines (2) in alkaline solution to form 2-alkyl-5,6-dihydro-(2H)-1,2,4-triazepine-3(4H)-thiones (3); the intermediate thiosemicarbazide derivatives (6), formed by addition of the hydrazine derivatives to the isothiocyanate group, could be isolated. CH3I and BrCH2COOC2H5 alkylate3 at sulfur, and the fusedring compounds14 and16 were isolated.

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Literatur

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Authors and Affiliations

  1. Pharmazeutisch-Chemisches Institut, Universität (TH) Karlsruhe, Bundesrepublik Deutschland

    Richard Neidlein & Wolf-Dieter Ober

  2. Pharmazeutisch-Chemisches Institut, Universität Heidelberg, Postfach 105760, D-6900, Heidelberg, Bundesrepublik Deutschland

    Richard Neidlein & Wolf-Dieter Ober

Authors
  1. Richard Neidlein
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  2. Wolf-Dieter Ober
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Additional information

Herrn Prof. Dr. Dr. h. c.K. E. Schulte zum 65. Geburtstag gewidmet.

Dissertation 1976, Universität Heidelberg.

R. Neidlein undW. D. Ober, Mh. Chem.107, 1241 (1976).

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Neidlein, R., Ober, WD. Synthesen von Siebenerringsystemen aus substituierten Isothiocyanaten und Hydrazinen. Monatshefte für Chemie 107, 1251–1258 (1976). https://doi.org/10.1007/BF00903814

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  • DOI: https://doi.org/10.1007/BF00903814

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