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An improved and one-pot procedure to the synthesis of symmetric amines by domino reactions of 5-methyl-1,3,4-thiadiazole-2-amine, a new nitrogen atom donor, and alkyl halides

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Abstract

A new one-pot method has been introduced in this work for the synthesis of symmetrical primary, secondary, and tertiary alkyl amines from alkyl halides and 5-methyl-1,3,4-thiadiazole-2-amine as a nitrogen-transfer reagent. In this method, all three types of amines have been successfully prepared after changing the ratio of substrates and base control. In addition to the introduction of a new nitrogen-transfer reagent, other important features of this work include normal atmospheric conditions and excellent yields under mild reaction conditions.

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Acknowledgements

We acknowledge the financial support of Ilam University Research Council.

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Authors and Affiliations

  1. Conclusions Chemistry Department, Ilam University, PO Box 69315-516, Ilam, Iran

    Mohammad Soleiman-Beigi & Fariba Mohammadi

Authors
  1. Mohammad Soleiman-Beigi
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  2. Fariba Mohammadi
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Corresponding author

Correspondence to Mohammad Soleiman-Beigi.

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Soleiman-Beigi, M., Mohammadi, F. An improved and one-pot procedure to the synthesis of symmetric amines by domino reactions of 5-methyl-1,3,4-thiadiazole-2-amine, a new nitrogen atom donor, and alkyl halides. Monatsh Chem 148, 2123–2128 (2017). https://doi.org/10.1007/s00706-017-2042-5

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  • DOI: https://doi.org/10.1007/s00706-017-2042-5

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