Abstract
Triton X-100, in concentrations below those liberating histamine, produced dose-dependent inhibition of histamine liberation from rat mast cells induced by substance 48/80. Triton X-100 (0.02 ml/liter) exhausted the ATP reserves in the mast cells and completely inhibited histamine liberation induced by substance 48/80, and exhaustion of the ATP content in the mast cells was abolished by glucose (10 mM). It was concluded that inhibition by Triton X-100 of histamine liberation induced by substance 48/80 depends on the inhibition of energy production.
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Gushchin, I.S., Deryugin, I.L. Inhibition by Triton X-100 of histamine liberation from mast cells induced by substance 48/80. Bull Exp Biol Med 87, 171–173 (1979). https://doi.org/10.1007/BF00833981
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DOI: https://doi.org/10.1007/BF00833981