Abstract
Originally Gosh and Schild (1958) introduced a method for the continuous recording of gastric acid secretion in the stomach lumen-perfused anesthetized rat. In this model gastric acid secretion can be stimulated by histamine, carbachol, or gastrin. Stimulated gastric acid secretion is inhibited by test drugs with antisecretory potential.
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References and Further Reading
Acid Secretion in Perfused Rat Stomach (Gosh and Schild Rat)
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Herling, A.W. (2014). Pharmacological Effects on Gastric Function. In: Hock, F. (eds) Drug Discovery and Evaluation: Pharmacological Assays. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27728-3_56-1
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