Advertisement

Bulletin of Experimental Biology and Medicine

, Volume 54, Issue 3, pp 1051–1053 | Cite as

Cytochemical investigations of fats and lipids in hepatic cells in toxic and alimentary fatty degeneration of the liver in rabbits

  • E. V. Chernysheva
  • N. I. Chumakova
  • F. L. Salimon
Morphology and Pathomorphology
  • 12 Downloads

Summary

Phospholipids were detected in the epithelial hepatic cells cytochemically by the MacManus reaction. Cytological and cytochemical alimentary cholesterol infiltration of the liver and toxic fatty degeneration of the liver was also detected in the rabbits. Fine vacuoles and a positive Schultz reaction are found in the former, and large coarse vacuoles and a positive Sudan III reaction were found in the latter. In both toxic fatty degeneration of the liver and alimentary cholesterol infiltration, the phospholipids of the epithelial hepatic cells decrease. The reduction of phospholipids in toxic fatty degeneration is evidently the primary cause, leading first to lipid and then to fatty decomposition, whereas in alimentary cholesterol infiltration, the reduction of phospholipids is secondary, and is due to the depressive effect of cholesterol. In toxic hepatic fatty degeneration, choline causes the disappearance of neutral fat from the liver, and a rise in the phospholipid content in both the liver and blood, but at the same time there is a marked protein dystrophy; this effect is likely to limit its application in medical practice. Simultaneous administration of substances for the prevention of protein dystrophy is not recommended.

Keywords

Public Health Lipid Cholesterol Choline Medical Practice 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature Cited

  1. 1.
    A. I. Abrikosov and A. I. Strukov, Pathological Anatomy, Part 1 [in Russian], Moscow, 1953, p. 126.Google Scholar
  2. 2.
    S. M. Leites, Uspekhi sovr. biol., 1946, vol. XXII, No. 2.Google Scholar
  3. 3.
    S. M. Leites, Arkh. pat., 1947, No. 3, p. 80.Google Scholar
  4. 4.
    N. B. Medvedeva. Guide to Pathological Physiology [in Russian], Moscow, 1941, p. 183.Google Scholar
  5. 5.
    S. M. Ryss and V. G. Smogin, Ter. arkh., 1958, No. 2, p. 37.Google Scholar
  6. 6.
    A. V. Palladin, Foundations of Pathological Anatomy, Chapter XII [in Russian], p. 435.Google Scholar
  7. 7.
    E. V. Chernysheva and A. V. Burgman, Arkh. pat., 1958, No. 8, p. 38.Google Scholar
  8. 8.
    E. V. Chernysheva and N. I. Chumakova, Ter. arkh., 1959, No. 9, p. 68.Google Scholar
  9. 9.
    S. S. Khalatov, Cholesterol Disease [in Russian], 1941.Google Scholar

Copyright information

© Consultants Bureau Enterprises, Inc. 1963

Authors and Affiliations

  • E. V. Chernysheva
    • 1
  • N. I. Chumakova
    • 1
  • F. L. Salimon
    • 1
  1. 1.I. M. Sechenov I Moscow Order of Lenin Medical InstituteHospital of Therapeutic TreatmentMoscowUSSR

Personalised recommendations