Summary
A stable population of intraspinal Schwann cells, which developed follwing early postnatal irradiation of the spinal cord, was challenged by the addition of tellurium (Te) to the diet beginning at 30 days of age. Schwann cells incorporating [3H]thymidine were identified by 1 μm autoradiographs and by conventional electron microscopy of adjacent thin sections. Autoradiographs of areas with Schwann cell myclination showed extensive labelling of cells in the Te-fed animals. In contrast, control animals which were not fed Te showed little evidence of labelled Schwann cells. These data indicate that Schwann cells in the intraspinal environment show a proliferative response to the presence of Te in the rat's diet, as do Schwann cells in their normal extraspinal milieu.
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Supported by National Multiple Sclerosis Society grant 1791-A-1, and NIH grant No. NS-23124 to I.D.D. Supported in part by NIH grant 04761, a Jacob Javits Neuroscience Investigator Award to S.A.G.
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Hammang, J.P., Worth, S.F., Duncan, I.D. et al. Proliferation of rat intraspinal Schwann cells following tellurium intoxication. Acta Neuropathol 76, 624–627 (1988). https://doi.org/10.1007/BF00689602
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DOI: https://doi.org/10.1007/BF00689602