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The in vivo dissociation of colonic and coprodeal transepithelial transport in NaCl depleted domestic fowl

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Summary

  1. 1.

    The contributions made by the coprodeum and by the colon to transepithelial transport were assessed in vivo, in the domestic fowl. Functional differences were established between these two epithelia that were neither revealed by previous in vitro nor in vivo studies.

  2. 2.

    With iso-osmotic perfusion, net colonic sodium ion flux (mucosa→serosa) was five times greater than the flux measured in coprodeum,J Na=100±24 μEq/kg·h and 19±6.3 μEq/kg·h, respectively.

  3. 3.

    Concomitant with net sodium ion flux was a solute-linked water flow, which in the colon averaged 176±34 μl/kg·h, but was virtually undetectable in the coprodeum (13±11 μl/kg·h).

  4. 4.

    Net chloride ion absorption accompanied sodium ion transport and was significantly higher in the colon than in the coprodeum (P<0.01).

  5. 5.

    Sodium transport-independent K+ secretion (serosa→mucosa) was observed with all treatments and in both coprodeum and colon. The magnitudes of the fluxes were not significantly different.

  6. 6.

    The coprodeum functions as a storage site for ureteral urine. Active modification of water and electrolyte composition of urine and chymus takes place almost exclusively in the colon.

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Abbreviations

m-s :

mucosa→serosa

s-m :

serosa→mucosa

ECPD :

electrochemical potential difference

P os :

osmotic permeability

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Authors and Affiliations

  1. Institute of Medical Physiology, Department A, University of Copenhagen, Blegdamsvej 3c, DK-2200, Copenhagen N, Denmark

    G. E. Rice & E. Skadhauge

Authors
  1. G. E. Rice
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  2. E. Skadhauge
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Rice, G.E., Skadhauge, E. The in vivo dissociation of colonic and coprodeal transepithelial transport in NaCl depleted domestic fowl. J Comp Physiol B 146, 51–56 (1982). https://doi.org/10.1007/BF00688716

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  • DOI: https://doi.org/10.1007/BF00688716

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