Abstract
In addition to digestion and absorption of nutrients, the intestinal tract has several essential functions, including a barrier to the outside environment, synthesis of secreted proteins, such as those required for fat absorption and immunoglobulin secretion, and elimination of waste products, as well as transport of salt and water. Failure to efficiently absorbing water and electrolyte, it will lead to dehydration and electrolyte imbalance. Most of these processes are dependent on the specialized mucosal functions and structural requirements discussed in this chapter. Particular emphasis will be placed on aspects of intestinal epithelial biology and the transport of fluid and electrolytes. The discussion of other mucosal functions such as digestion and absorption of nutrients will be covered in subsequent chapters in Part Two of this book.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Further Reading
Althaus M (2012) Gasotransmitters: novel regulators of epithelial Na+ transport. Front Physiol 3 (Article 83):1–10
Ghishan FK, Kiela PR (2012) Ion transport in the small intestine. Curr Opin Gastroenterol 28:130–134
Gill RK, Alrefai WA, Borthakur A, Dudeja PK (2012) Intestinal anion absorption. In: Johnson LR (ed) Physiology of the gastrointestinal tract, 5th edn. Academic, New York, pp 1819–1847
Heitzmann D, Warth R (2008) Physiology and pathophysiology of potassium channels in gastrointestinal epithelia. Physiol Rev 88:1119–1182
Kato A, Romero MF (2011) Regulation of electroneutral NaCl absorption by the small intestine. Annu Rev Physiol 73:261–281
Keita AV, Söderholm JD (2010) The intestinal barrier and its regulation by neuroimmune factors. Neurogastroenterol Motil 22:718–733
Kiela PR, Ghishan FK (2009) Ion transport in the intestine. Curr Opin Gastroenterol 25:87–91
Kiela PR, Ghishan FK (2012) Na+/H+ exchange in mammalian digestive tract. In: Johnson LR (ed) Physiology of the gastrointestinal tract, 5th edn. Academic, New York, pp 1781–1818
Laforenza U (2012) Water channel proteins in the gastrointestinal tract. Mol Aspects Med 33:642–650
Malakooti J, Saksena S, Gill RK, Dudeja PK (2011) Transcriptional regulation of the intestinal luminal Na+ and Cl− transporters. Biochem J 435:313–325
Murek M, Kopic S, Geibel J (2010) Evidence for intestinal chloride secretion. Exp Physiol 95:471–478
Thiagarajah JR, Verkman AS (2012) Water transport in the gastrointestinal tract. In: Johnson LR (ed) Physiology of the gastrointestinal tract, 5th edn. Academic, New York, pp 1757–1780
Author information
Authors and Affiliations
Corresponding authors
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Chang, E.B., Leung, P.S. (2014). Intestinal Water and Electrolyte Transport. In: Leung, P. (eds) The Gastrointestinal System. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-8771-0_5
Download citation
DOI: https://doi.org/10.1007/978-94-017-8771-0_5
Published:
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-017-8770-3
Online ISBN: 978-94-017-8771-0
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)