Abstract
Clearance experiments have been performed to study the effects of saline infusion on the reabsorption of inorganic sulfate (SO4) at endogenous levels. Adult female Sprague-Dawley rats on a standard diet were used. Both intact and thyroparathyroidectomized (TPTX) animals were infused with a 130 mmol/l sodium chloride solution at a low (0.15 ml/min) and a high (0.375 ml/min) rate. This increase of the infusion rate decreased the reabsorption of SO4 in both groups of animals significantly. The fractional excretion of SO4 in theintact rats increased from 9.9±5.6 to 18.4±3.6% (mean values±SD,p<0.001) and in theTPTX rats from 5.3±2.5 to 22.4±6.3% (p<0.001). It is concluded that endogenous parathyroid hormone has no major effect on the saline-induced inhibition of reabsorption of SO4.
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This work was supported by a grant from the Deutsche Forschungsgemeinschaft (Fr 239/9-1)
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Frick, A., Durasin, I. & Neuweg, M. Effect of saline infusion on net reabsorption of endogenous sulfate relative to that of phosphate in intact and thyroparathyroidectomized rats. Pflugers Arch. 406, 387–391 (1986). https://doi.org/10.1007/BF00590941
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DOI: https://doi.org/10.1007/BF00590941