Abstract
Incretins are hormones with a wide range of biological activity. We studied the ratio of the glycemic effect of the glucagon-like peptide-1 mimetic and its effect on the renal excretion of sodium and water. It was found that both effects depend on the initial blood concentration of glucose. In normoglycemia, exenatide had no effect on blood sugar level, but it significantly increased urinary sodium excretion and reabsorption of solute-free water. In hyperglycemia the blood glucose concentration was normalized by exenatide, while the excretion of sodium by the kidneys and the reabsorption of solute-free water were increased to a small extent. This pattern was found both in patients with type 2 diabetes mellitus and in rats with hyperglycemia induced by intraperitoneal injection of glucose.
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Funding
This study was carried out in the framework of the state contract of the Federal Agency for Scientific Organizations of Russia (state registration no. АААА-А18-118012290371-3) and supported in part by the Russian Foundation for Fundamental Research, project no. 17-04-01216.
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Statement on the welfare of animals. All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.
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Kutina, A.V., Balbotkina, E.V., Karavashkina, T.A. et al. Effect of the Glucagon-like Peptide-1 Mimetic on Ion- and Osmoregulating Renal Functions in Normoglycemia and Hyperglycemia. Hum Physiol 45, 685–692 (2019). https://doi.org/10.1134/S036211971904008X
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DOI: https://doi.org/10.1134/S036211971904008X