Summary
Clearance studies were performed in order to examine the effect of expansion of extracellular fluid volume (ECFV) on the maximal reabsorptive capacity for inorganic phosphate (TmPi) in acutely parathyroidectomized (PTX) and intact rats. TmPi values were obtained in both control and volume expansion. In PTX rats, the TmPi values in control and expansion were 8.25±1.52 and 6.14±1.02 μmol/min (mean values ±S.D.), respectively; the TmPi/ GFR values were 2.96±0.31 and 2.09±0.30 μmol/ml, respectively. Inintact rats, the TmPi values in control and expansion were 3.56±0.94 and 2.98 ±0.94 μmol/min, respectively, and the TmPi/GFR values were 1.34±0.23 and 1.05±0.23 μmol/ml, respectively. From these results it is concluded that expansion of ECFV decreases the TmPi values both in the absence and presence of parathyroid hormone.
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This work was supported in part by a grant from the “Deutsche Forschungsgemeinschaft” (Fr 239/5)
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Frick, A., Durasin, I. Effect of expansion of extracellular fluid volume on the maximal reabsorptive capacity for inorganic phosphate in parathyroidectomized and intact rats. Pflugers Arch. 370, 115–119 (1977). https://doi.org/10.1007/BF00581683
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DOI: https://doi.org/10.1007/BF00581683