Skip to main content
SpringerLink
Log in

Verwendung der Lyophilisation bei der chemisch-toxikologischen Analyse

  • Published:
Archiv für Toxikologie Aims and scope Submit manuscript

Summary

The extractable poisons have been isolated from biological materials beforehand lyophilized, from blood or from homogenized tissues. The extraction has been achieved with different organic solvents. These extracts were free of unwanted emulsions; after the evaporation of the solvents to dryness a very pure substances have been obtained, which were finally used for the identification and for the quantitative determination. This method has been successfully proved with such drugs like barbiturates, non-barbiturate hypnotics, alcaloids, analgetics and isoniazid (INH) not only in model experiments, but also in the forensic and clinical cases.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literatur

  • Curry, A. S., andS. E. Phang: New apparatus: a continuous extractor for use in toxicological analysis. J. Pharm. Pharmacol.12, 437–441 (1960).

    Google Scholar 

  • Dressler, A., M. Müller u.H. Schönfeld: Über die Isolierung reiner Barbiturate im Verlauf der chemisch-toxikologischen Analyse. Arch. Toxikol.17, 286–292 (1959).

    Google Scholar 

  • Flosdorf, E. W.: Freeze-drying. New York: Reinhold Publ. Co. 1949.

    Google Scholar 

  • Flosdorf, E. W.: Quick freezing and freezing drying. Aus der BuchpublikationF. M. Über, Biophysical research methods. New York: Interscience Publ. 1950.

    Google Scholar 

  • Kido, M.: An experimental study on the effect putrefaction on the detection of organic poisons in the organs. Jap. J. Legal Med.11, 638–663 (1957).

    Google Scholar 

  • Macek, K., u.J. Večerková: Neues Verfahren der systematischen Analyse von Arzneimitteln durch Papier- und Dünnschichtchromatographie. Pharmazie20, 605–616 (1965).

    Google Scholar 

  • Maresch, W.: Selbstmorde durch rectale Applikation von Schlafmitteln. Arch. Kriminol.134, 172–177 (1964).

    Google Scholar 

  • Pulver, R.: Die Verteilung von Medikamenten zwischen Blutkörperchen und Plasma. Arzneimittel-Forsch.15, 1363–1365 (1965).

    Google Scholar 

  • Rey, L.: Aspects théoriques et industriels de la lyophilisation. Paris: Hermann 1964.

    Google Scholar 

  • Vidic, E.: Anwendung der multiplikativen Verteilung in der Toxikologie. Arch. Toxikol.21, 43–66 (1965).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut für Gerichtliche Medizin der Karls-Universität in Prag, Tschechoslowakei

    Jiří Erben

Authors
  1. Jiří Erben
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Vorgetragen am 1. Dezember 1966 während des 13. Kongresses der Gerichtsärzte in Prag.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Erben, J. Verwendung der Lyophilisation bei der chemisch-toxikologischen Analyse. Arch. Toxikol. 22, 410–413 (1967). https://doi.org/10.1007/BF00577596

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00577596

Search

Navigation