Abstract
A method has been developed for the determination of tetrodotoxin in water, blood plasma, and drugs at a level of 0.05—1.0 µg/mL. The method is based on the hydrolytic decomposition of tetrodotoxin by a sodium hydroxide solution, extraction of 2-amino-6-hydroxymethyl-8-hydroxyquinazoline using liquid–liquid extraction, preparation of its derivative by reaction with N,O-bis(trimethylsilyl)trifluroacetamide, and the determination of the derivative by gas–liquid chromatography with a mass-spectrometric detector.
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Original Russian Text © I.N. Stan’kov, V.B. Kondrat’ev, I.D. Derevyagina, O.T. Morozova, V.I. Selivanova, F.M. Semchenko, K.A. Rufanov, S.I. Dvoretskaya, 2016, published in Zhurnal Analiticheskoi Khimii, 2016, Vol. 71, No. 3, pp. 302–309.
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Stan’kov, I.N., Kondrat’ev, V.B., Derevyagina, I.D. et al. Gas-chromatographic determination of trace amounts of tetrodotoxin in water, drugs, and blood plasma. J Anal Chem 71, 289–296 (2016). https://doi.org/10.1134/S1061934816030138
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DOI: https://doi.org/10.1134/S1061934816030138