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The blood tumour barrier in intracranial tumours studied with X-ray computed tomography and positron emission tomography using 68-Ga-EDTA

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Summary

Disruption of the blood brain barrier or rather blood tumour barrier in cerebral tumours was studied with CT after intravenous injection of contrast medium and with PET after intravenous administration of 68-Ga-EDTA. Histology from stereotactic biopsies or open surgery is compared with the radiologic findings and advantages of the respective methods are discussed. The material consisted of 47 patients mainly with supratentorial gliomas and a few miscellaneous tumours. Astrocytomas (Kernohan grade II) were found to have no disruption of blood tumour barrier while anaplastic astrocytomas and glioblastomas (Kernohan grade III and IV) had. PET is somewhat superior to CT in detection of disruption of the blood tumour barrier. It is concluded that the combination of CT and PET is of value in the assessment of intracranial tumours.

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References

  1. Butler AR, Berenstein A, Kricheff II (1978) The contrast-enhanced CT scan and the radionucleide brain scan. Parallel mechanisms of action in detection of supratentorial astrocytomas. Neuroradiology 16: 491–494

    Google Scholar 

  2. Gado MH, Phelps ME, Coleman RE (1975) An extravascular component to contrast enhancement in cranial computed tomography. Radiology 117: 589–593 and 595–597

    Google Scholar 

  3. Long DM (1970) Capillary ultrastructure and the blood-brain barrier in human malignant brain tumours. J Neurosurg 32: 127–144

    Google Scholar 

  4. Lewander R, Bergström M, Bergvall U (1978) Contrast enhancement of cranial lesions in computed tomography. Acta Radiol (Diagn) 19:529–555

    Google Scholar 

  5. Shalen P, Hayman A, Wallace S, Handel S (1981) Protocol for delayed contrast enhancement in computed tomography of cerebral neoplasia. Radiology 139:397–402

    Google Scholar 

  6. Ilsen HW, Sato M, Pawlik G, Herholz K, Wienhard K, Heiss W-D (1984) 68-Ga-EDTA positron emission tomography in the diagnosis of brain tumours. Neuroradiology 26:393–398

    Google Scholar 

  7. Ericson K, Bergström M, Eriksson L, Hatam A, Greitz T, Söderström CE, Widén L (1981) Positron emission tomography with 68-Ga-EDTA compared with transmission computed tomography in the evaluation of brain infarcts. Acta Radiol (Diagn) 22:385–398

    Google Scholar 

  8. Eriksson L, Bohm C, Kesselberg M, Blomqvist G, Litton J, Widén L, Bergström M, Ericson K, Greitz T (1982) A four ring positron camera system for emission tomography of the brain. IEEE Trans Nucl Sci 29:539–543

    Google Scholar 

  9. Eriksson L, Bohm C, Bergström M, Ericson K, Greitz T, Blomqvist G, Litton J, Widén L, Hansen P, Holte S, Stjernberg H (1983) Design characteristics of a multiring positron camera system for emission tomography of the brain. In: Heiss WD, Phelps ME (eds) Positron emission tomography of the brain. Springer, Berlin Heidelberg New York, pp 40–45

    Google Scholar 

  10. Hayman A, Evans R, Hinck V (1979) Rapid-high-dose contrast computed tomography of isodense subdural hematoma and cerebral swelling. Radiology 131:381–383

    Google Scholar 

  11. Davis J, Davis K, Newhouse J, Pfister R (1979) Expanded high dose in computed cranial tomography: A preliminary report. Radiology 131:373–380

    Google Scholar 

  12. Pullicino P, Kendall BE (1980) Contrast enhancement in ischaemic lesions. Neuroradiology 19:235–239

    Google Scholar 

  13. Pullicino P, Kendall BE (1980) Intravascular contrast injection in ischaemic lesions. Neuroradiology 19:241–243

    Google Scholar 

  14. Ansell G (1968) A national survey of radiological complications. Interime report. Clin Radiol 19:175–191

    Google Scholar 

  15. Ansell G (1970) Adverse reactions to contrast agents. Invest Radiol 5:374–384

    Google Scholar 

  16. Shehadi WH (1975) Adverse reactions to intravascularly administered contrast media. A comprehensive study based on a prospective survey. Amer J Roentgenol 124:145–152

    Google Scholar 

  17. Shehadi WH, Mishk MM (1973) Preliminary report of the committee on contrast media of the international society of radiology. Int Congr Radiology, Madrid

  18. Lindgren E (1973) Metrizamide. A non-ionic water-soluble contrast medium. Acta Radiol [Suppl] 335

  19. Lindgren E (1977) Metrizamide-Amipaque. The non-ionic water-soluble contrast medium. Acta Radiol [Suppl] 355

  20. Lindgren E (1980) Iohexol. A non-ionic contrast medium. Acta Radiol [Suppl] 362

  21. von Holst H, Bergström M, Möller A, Steiner L, Ribbe T (1977) Titanium clips in neurosurgery for elimination of artifacts in computer tomography. Acta Neurochir 38:101–109

    Google Scholar 

  22. von Holst H, Collins P, Steiner L (1981) Titanium, silver and tantalum clips in brain tissue. Acta Neurochir 56:239–242

    Google Scholar 

  23. Hatam A, Bergvall U, Lewander S, Larsson S Lind M (1975) Contrast medium enhancement with time in computer tomography. Acta Radiol [Suppl] 346:63–81

    Google Scholar 

  24. Naidich TP, Pudlowski RM, Leeds NE, Naidich JB, Crisholm AJ, Rifkin MD (1977) The normal contrast-enhanced computed axial tomography of the brain. J Comput Assist tomogr 1:16–29

    Google Scholar 

  25. Nukui H, Yamamoto YL, Thompson CJ, Feindel W (1979) Positron emission tomography with Positome II: With special reference to 68-Ga-EDTA positron emission tomography in cases with brain tumour. Neurol Med Chir (Tokyo) 19:941–954

    Google Scholar 

  26. Bergström M, Boethius J, Eriksson L, Greitz T, Ribbe T, Widén L (1981) Head fixation device for reproducible position alignment in transmission CT and positron emission tomography. J Comput Assist Tomogr 5:136–141

    Google Scholar 

  27. Greitz T, Bergström M, Boethius J, Kingsley D, Ribbe T (1980) Head fixation system for integration of radiodiagnostic and therapeutic procedures. Neuroradiology 19:1–6

    Google Scholar 

  28. Kingsley DPE, Bergström M, Berggren B-M (1980) A critical evaluation of two methods of head fixation. Neuroradiology 19:7–12

    Google Scholar 

  29. Boethius J, Bergström M, Greitz T, (1980) Stereotaxic computerized tomography with a GE 8800 scanner. J Neurosurg 52:794–800

    Google Scholar 

  30. Ericson K, Lilja A, Bergström M, Collins VP, Eriksson L, Ehrin E, von Holst H, Lundquist H, Långström B, Mosskin M (1985) Positron emission tomography with 11-C-methionine, 11-C-glucose and 68-Ga-EDTA in the examination of supratentorial tumors. J Comput Assist Tomogr 9:683–689

    Google Scholar 

  31. Bergström M, Collins P, Ehrin E, Ericson K, Eriksson L, Greitz T, Halldin C, v Holst H, Långström B, Lilja A, Lundqvist H, Någren N (1983) Discrepancies in brain tumour extent as shown by computed tomography and positron emission tomography using 68-Ga-EDTA, 11-G-glucose and 11-C-methionine. J Comput Assist Tomogr 7:1062–1066

    Google Scholar 

  32. Patronas NJ, Brooks RA, DeLaPaz RL, Smith BH, Kornblith PL, DiChiro G (1983) Glycolytic rate (PET) and contrast enhancement (CT) in human cerebral gliomas. AJNR 4:533–535

    Google Scholar 

  33. DiChiro G, DeLaPaz RL, Brooks RA et al (1982) Glucose utilization of cerebral gliomas measured by 18-F-fluorodeoxy-glucose and positron emission tomography. Neurology 32:1323–1329

    Google Scholar 

  34. Greitz T, Ingvar D, Widén L (eds) (1985) The metabolism of the Human brain studied with positron emission tomography. Raven Press, New York

    Google Scholar 

  35. Daumas-Duport C, Meder JF, Monsaingeon V, Missir O, Aubin ML, Szikla G (1983) Cerebral gliomas: malignancy, limits and spatial configuration. J Neuroradiol 10:51–80

    Google Scholar 

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Authors and Affiliations

  1. Department of Neuroradiology, Karolinska Hospital, Stockholm, Sweden

    M. Mosskin & K. Ericson

  2. Department of Neurosurgery, Karolinska Hospital, Stockholm, Sweden

    H. von Holst & G. Norén

Authors
  1. M. Mosskin
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  2. H. von Holst
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  3. K. Ericson
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  4. G. Norén
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Mosskin, M., von Holst, H., Ericson, K. et al. The blood tumour barrier in intracranial tumours studied with X-ray computed tomography and positron emission tomography using 68-Ga-EDTA. Neuroradiology 28, 259–263 (1986). https://doi.org/10.1007/BF00548201

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  • DOI: https://doi.org/10.1007/BF00548201

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