Abstract
Perphenazine enanthate 3.4 mg/kg per injection, was administered subcutaneously to rats every second week over a period of a year, a total of 31 mg per animal being given. The animals were observed weekly and only a few became cataleptic during brief periods. After treatment for one year, 3H-uridine and 3H-lysine were administered intravenously and the labelling was studied by micro-autoradiography. Labelling of the cortical cells in the treated animals was found to be slightly greater than in the control animals. The converse was found in the basal ganglia in the case of uridine. None of these differences were significant.
In counting nerve cells in the cortex and in the basal ganglia, a significantly lower number of nerve cells was found in the basal ganglia in the treated group.
Histological investigation of lungs, liver, spleen and kidneys showed only insignificant changes in the tissues.
All the investigations mentioned were performed blind.
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Pakkenberg, H., Fog, R. & Nilakantan, B. The long-term effect of perphenazine enanthate on the rat brain. Some metabolic and anatomical observations. Psychopharmacologia 29, 329–336 (1973). https://doi.org/10.1007/BF00429280
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DOI: https://doi.org/10.1007/BF00429280