The effects of derivatives of 3-hydroxypyridine and succinic acid (emoxypine, Reamberin, and Mexidol) on the state of cerebral dopaminergic processes were studied using catalepsy and stereotypical “verticalization” (climbing) behavior as criteria in experiments on mice. Single doses of emoxypine, Reamberin, and Mexidol at doses equivalent to the therapeutic range for humans were found to potentiate apomorphine-induced stereotypical behavior and to decrease the cataleptogenic effect of haloperidol. All studied derivatives of 3-hydroxypyridine and succinic acid increased spontaneous catalepsy. Emoxypine and Reamberin stimulated spontaneous stereotypical behavior in mice. The intrinsic cataleptogenic activity of the agents studied here correlated negatively with their influences on spontaneous stereotypical behavior. The nature of changes in stereotypical behavior and catalepsy in response to the test compounds provided evidence of an apparent similarity between their effects on dopaminergic processes and the phenotype of the pharmacological action of partial agonists of dopamine receptors.
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I. A. Volchegorskii, I. I. Dolgushin, O. L. Kolesnikov, and V. E. Tseilikman, Experimental Modeling and Laboratory Evaluation of the Adaptive Reactions of the Body, Chelyabinsk State Pedagogical University Press, Chelyabinsk (2000).
I. A. Volchegorskii and N. V. Mester, “Effects of antioxidants of the 3-hydroxypyridine group on depression in patients with diabetes mellitus,” Klin. Med., No. 2, 40–45 (2007).
I. A. Volchegorskii and K. M. Mester, “Effects of derivatives of 3-hydroxypyridine and succinic acid on the dynamics of pain syndrome and affective disorders after removal of herniated intervertebral disks,” Eksperim. Klin. Farmakol., 73, No. 1, 33–39 (2010).
I. A. Volchegorskii, L. M. Rassokhina, I. Yu. Miroshnichenko, K. M. Mester, P. N. Novoselov, and T. V. Astakhova, “Effects of pro- and antioxidants on insulin sensitivity and glucose tolerance,” Byull. Eksperim. Biol. Med., 150, No. 9, 295–301 (2010).
I. A. Volchegorskii, I. Yu. Miroshnichenko, L. M. Rassokhina, and R. M. Faizullin, “Studies of the antidepressant activity of derivatives of 3-hydroxypyridine and succinic acid in experiments on mice,” Eksperim. Klin. Farmakol., 76, No. 7, 6–10 (2013).
I. A. Volchegorskii, I. Yu. Miroshnichenko, L. M. Rassokhina, R. M. Faizullin, and K. E. Pryakhina, “Effects of derivatives of 3-hydroxypyridine and succinic acid on obsessive-compulsive activity in mice in the ‘ball burying’ test,” Eksperim. Klin. Farmakol., 77, No. 10, 10–14 (2014).
I. A. Volchegorskii, I. Yu. Miroshnichenko, L. M. Rassokhina, R. M. Faizullin, K. E. Pryakhina, M. P. Malkin, and A. V. Kalugina, “Experimental studies of the effects of derivatives of 3-hydroxypyridine and succinic acid on resistance to acute cerebral ischemia,” Zh. Nevrol. Psikhiat. im. S. S. Korsakova, No. 12, 123–127 (2014).
T. A. Voronina, “The antioxidant Mexidol. Main neuropsychotropic effects and mechanism of action,” Psikhofarmakol. Biol. Narkol., 1, No. 1, 2–12 (2001).
V. P. Galenko-Yarosheskii, O. N. Gulevskaya, A. V. Zelenskaya, V. V. Seletskaya, S. K. Bogus, V. L. Popkov, and S. V. Gatsura, “Current challenges in the correction of impairments to oxidative homeostasis in experimental pharmacology,” Nov. Tekhnol., No. 2, 166–171 (2011).
European Convention of the Protection of Vertebrates Used for Experimental or Other Scientific Purposes, EST No. 123 of March 18, 1986, Strasbourg (1986).
E. A. Katunina, “The potential for the use of antioxidant therapy in patients with Parkinson’s disease,” Eksperim. Klin. Farmakol., 68, No. 5, 18–20 (2005).
E. S. Kovaleva, L. L. Prilipko, K. O. Muranov, and V. E. Kagan, “Actions of antioxidants on release of 3H-serotonin by rat brain synaptosomes,” Byull. Eksperim. Biol. Med., 96, No. 10, 55–57 (1983).
O. A. Popova, V. S. Kudrin, P. M. Klodt, V. B. Narkevich, L. N. Nerobkova, I. G. Kapitsa, T. A. Voronina, and E. A. Val’dman, “Effects of Mexidol on neurochemical changes in rat brain structures in modeling of Parkinson’s syndrome,” Vestn. Ros. Gos. Med. Univ., No. 1, 54–58 (2008).
K. S. Raevskii, “Current neuroleptics: interaction with brain neurotransmitter systems,” Psikh. Psikhofarmakoter., 2, No. 5, 132–134 (2000).
Guidelines for Preclinical Studies of Medicines, A. N. Mironov (ed.) Grif i K, Moscow (2012).
K. Yu. Sarkisova, M. A. Kulikov, I. S. Midzyanovskaya, and A. A. Folomkina, “The dopamine-dependent nature of depression-like behavior in WAG/Rij rats with genetic absence epilepsy,” Zh. Vyssh. Nerv. Deyat. I. P. Pavlova, 57, No. 1, 91–102 (2007).
L. Bardin, M. S. Kleven, C. Barret-Grevoz, R. Depoortere, and A. Newman-Tancredi, “Antipsychotic-like vs. cataleptogenic actions in mice of novel antipsychotics having D2 antagonist and 5-HT1A agonist properties,” Neuropsychopharmacology, 31, 1869–1879 (2006).
D. Boulay, O. Bergis, P. Avenet, and G. Griebel, “The glycine transporter-1 inhibitor SSR103800 displays a selective and specific antipsychotic-like profile in normal and transgenic mice,” Neuropsychopharmacology, 35, 416–427 (2010).
A. Carlsson and M. L. Carlsson, “A dopaminergic deficit hypothesis of schizophrenia: the path to discovery,” Dialogues Clin. Neurosci., 8, 137–142 (2006).
R. Depoortere, L. Bardin, A. L. Auclair, M. S. Kleven, E. Prinssen, F. Colpaert, B. Packer, and A. Newman-Tancredi, “F15063, a compound with D2/D3 antagonist, 5-HT 1a agonist and D4 partial agonist properties. II. Activity in models of positive symptoms of schizophrenia,” Br. J. Pharmacol., 151, 253–265 (2007).
O. Erbas, H. S. Akseki, B. Elikucuk, and D. Taskiran, “Antipsychotic-like effect of trimetazidine in a rodent model,” Bull. Clin. Psychopharmacology, 24, No. 1, 40–45 (2014).
R. Frau, G. Pillolla, V. Bini, S. Tambaro, P. Devoto, and M. Bortolato, “Inhibition of 5α-reductase attenuates behavioral effects of D1-but not D2-like receptor agonists in C57BL/6 mice,” Psychoneuroendocrinology, 38, No. 4, 542–551 (2013).
S. Inanir, U. S. Copoglu, H. Kokacya, R. Dokuyucu, O. Erbas, and A. Inanir, “The agomelatine protection in LPS-induced psychosis-relevant behavior model,” Med. Sci. Monit., 21, 3834–3839 (2015).
F. Lavergne and T. M. Jay, “A new strategy for antidepressant prescription,” Front. Neurosci., 192. No. 4, 1–13 (2010).
D. Makmood, R. Khanam, K. K. Pillai, and M. Akktar, “Protective effects of histamine H3-receptor ligands in schizophrenic behaviors in experimental models,” Pharmacol. Rep., 64, 191–204 (2012).
G. H. Perrault, R. Depoortere, E. Morel, D. J. Sanger, and B. Scatton, “Psychopharmacological profile of amisulpride: an antipsychotic drug with presynaptic D2/D3 dopamine receptor antagonist activity and limbic selectivity,” J. Pharmacol. Exp. Therap., 280, 73–82 (1997).
H. Skarifi , A. M. Nayebi, and S. Farajnia, “The effect of chronic administration of buspirone on 6-hydroxydopamine-induced catalepsy in rats,” Adv. Pharm. Bull., 2, No. 1, 127–131 (2012).
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Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 103, No. 4, pp. 406–416, April, 2017.
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Volchegorskii, I.A., Miroshnichenko, I.Y., Rassokhina, L.M. et al. Effects of Derivatives of 3-Hydroxypyridine and Succinic Acid on Stereotypical Behavior and Catalepsy in Mice. Neurosci Behav Physi 48, 947–953 (2018). https://doi.org/10.1007/s11055-018-0654-9
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DOI: https://doi.org/10.1007/s11055-018-0654-9