Summary
A variant chromosome no. 21 consisting of two stalks and two satellites in tandem was detected during a survey of a human isolate. The variant segregated in three generations of a large kindred. One male had the variant no. 21, a metacentric Y, and a 47, XXY complement; however, no other evidence of chromosomal nondisjunction was found. Computer-aided analysis of sequentially stained variant no. 21 chromosomes indicated that silver-stained material corresponded to the proximal stalk region (as defined defined by Giemsa). These data support the hypothesis that human nucleolar organizers are localized to the stalks of acrocentric chromosomes.
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Martin, A.O., Miller, L., Simpson, J.L. et al. Localization of the nucleolar organizer by computer-aided analysis of a variant no. 21 in a human isolate. Hum Genet 48, 211–219 (1979). https://doi.org/10.1007/BF00286906
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DOI: https://doi.org/10.1007/BF00286906