Summary
This study was an investigation of the effects of the tachykinin antagonists, spantide and (d-Pro4, d-Trp7, 9, 10)substance P 4-11, injected intracerebroventricularly (ICV), on the locomotor and behavioural responses of guinea-pigs to substance P (SP) injected ICV and to naloxone-induced morphine withdrawal. SP, 50 nmol, produced increased locomotor activity and behaviour that mimicked the response induced by injection of naloxone hydrochloride, 15 mg/kg, in guinea-pigs treated 2 h previously with morphine sulphate, 15 mg/kg. Spantide or (d-Pro4, d-Trp7, 9, 10)SP4-11, 10 nmol, reduced the locomotor and behavioural responses to SP and to morphine withdrawal. The results support the suggestion that SP or a related tachykinin might be a mediator of the opioid withdrawal response in the central nervous system as has been proposed for the enteric nervous system.
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Johnston, P.A., Chahl, L.A. Tachykinin antagonists inhibit the morphine withdrawal response in guinea-pigs. Naunyn-Schmiedeberg's Arch Pharmacol 343, 283–288 (1991). https://doi.org/10.1007/BF00251127
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DOI: https://doi.org/10.1007/BF00251127