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Effects of Aminoadamantane Derivatives on Morphine-Induced Analgesia in Mice

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The effects of low-affinity NMDA-receptor antagonists amantadine (1-aminoadamantane hydrochloride) and hemantane [N-(2-adamantyl)hexamethyleneimine hydrochloride] on morphine-induced analgesia in C57Bl/6 mice were studied. Amantadine (10 and 20 mg/kg, i.p.) per se did not affect the latent period of the response in the hot-plate test while hemantane (10 and 20 mg/kg, i.p.) increased dose-dependently pain thresholds 180 and 240 min after administration. Morphine (20 mg/kg, s.c.) showed a time—effect dependence (30 – 120 min). The aminoadamantanes were administered 90 min after the opioid to assess their effects on morphine-induced antinociception. The responses of the animals were recorded for the next 2.5 h. The aminoadamantanes potentiated and extended the analgesic activity of morphine in the order of efficacy amantadine < hemantane. The results indicated that the aminoadamantanes had different capabilities to cause delayed analgesia and modulated opioid antinociceptive activity at the supraspinal level.

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Authors and Affiliations

  1. V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences, 8 Baltiiskaya St., Moscow, 125315, Russia

    L. G. Kolik, A. V. Nadorova, I. V. Chernyakova & E. A. Val’dman

Authors
  1. L. G. Kolik
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  2. A. V. Nadorova
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  3. I. V. Chernyakova
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  4. E. A. Val’dman
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Correspondence to L. G. Kolik.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 54, No. 4, pp. 15 – 19, April, 2020.

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Kolik, L.G., Nadorova, A.V., Chernyakova, I.V. et al. Effects of Aminoadamantane Derivatives on Morphine-Induced Analgesia in Mice. Pharm Chem J 54, 340–344 (2020). https://doi.org/10.1007/s11094-020-02202-1

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  • DOI: https://doi.org/10.1007/s11094-020-02202-1

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