Summary
Short or long daily administration of various barbiturates to rats or mice accelerates the in vivo and in vitro oxidation of hexobarbital (Evipan) and the in vitro demethylation of methylaminoantipyrin in the liver microsomes. Longer acting barbiturates have a stronger stimulating effect than short acting derivatives. The half time for the breakdown of hexobarbital in mice falls from 81 min. for the control group to 19 min. for a group pretreated 4 days with 100 mg./kg. barbital s.c. daily.
Hexobarbital which is rapidly oxidized in the livermicrosomes can activate these enzymatic reactions least. But if the action of hexobarbital is prolonged by a substance inhibiting its breakdown it acts like barbital.
These experiments prove that in animals “tolerant” to barbiturates unspecific oxidative reactions in the livermicrosomes are accelerated.
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Herrn Prof. Dr. W. S. Loewe, Salt Lake City, zum 75. Geburtstag in Verehrung gewidmet.
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Remmer, H. Die Beschleunigung der Evipanoxydation und der Demethylierung von Methylaminoantipyrin durch Barbiturate. Naunyn - Schmiedebergs Arch 237, 296–307 (1959). https://doi.org/10.1007/BF00244737
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DOI: https://doi.org/10.1007/BF00244737